PMID- 37559461
OWN - NLM
STAT- MEDLINE
DCOM- 20230824
LR  - 20230909
IS  - 2041-6008 (Electronic)
IS  - 2041-5990 (Linking)
VI  - 14
IP  - 7
DP  - 2023 Jul
TI  - A short appraisal of polylactic-co-glycolic acid based polymer nanotechnology for 
      colon cancer: recent advances and literature evidences.
PG  - 459-472
LID - 10.4155/tde-2023-0027 [doi]
AB  - The currently available formulations provided non-targeted treatment of colon 
      cancer, the deadliest cancer variant. Due to biopharmaceutical hindrances, the 
      majority of the drugs are unable to reach the target site. Polylactic-co-glycolic 
      acid (PLGA) is one of the versatile polymers in cancer treatment, diagnostics and 
      theranostics. The unique mechanism of surface modifications in PLGA properties in 
      colon cancer has been a keen interest to be used in different nanoparticles for 
      improving biopharmaceutical attributes. The ongoing use of these smart 
      nano-carriers has allowed targeted delivery of several active components on a 
      wide scale. The main goal of this review is to compile information on PLGA-based 
      nanocarriers which possess several desirable properties for drug delivery 
      applications, including biocompatibility, biodegradability and tunable 
      drug-release kinetics.
FAU - Vashishat, Abhinav
AU  - Vashishat A
AD  - Department of Pharmaceutics, ISF College of Pharmacy, GT Road, Moga, Punjab, 
      142001, India.
FAU - Singh, Amrinder
AU  - Singh A
AD  - Chitkara College of Pharmacy, Chitkara University, Punjab, 140417, India.
FAU - Kurmi, Balak Das
AU  - Kurmi BD
AD  - Department of Pharmaceutics, ISF College of Pharmacy, GT Road, Moga, Punjab, 
      142001, India.
FAU - Gupta, Ghanshyam Das
AU  - Gupta GD
AD  - Department of Pharmaceutics, ISF College of Pharmacy, GT Road, Moga, Punjab, 
      142001, India.
FAU - Singh, Dilpreet
AU  - Singh D
AUID- ORCID: 0000-0002-2176-9420
AD  - University Institute of Pharmaceutical Sciences, Chandigarh University, Gharuan, 
      Mohali, 140413, India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230809
PL  - England
TA  - Ther Deliv
JT  - Therapeutic delivery
JID - 101538870
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 0 (Polymers)
RN  - 0 (Glycols)
RN  - 0WT12SX38S (glycolic acid)
RN  - 0 (Drug Carriers)
SB  - IM
MH  - Humans
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers
MH  - Glycols
MH  - Drug Delivery Systems
MH  - Nanotechnology
MH  - *Nanoparticles
MH  - *Colonic Neoplasms/drug therapy
MH  - Drug Carriers
OTO - NOTNLM
OT  - PLGA
OT  - colon cancer
OT  - nanotechnology
OT  - target delivery
OT  - theranostics
EDAT- 2023/08/10 06:42
MHDA- 2023/08/24 06:42
CRDT- 2023/08/10 02:33
PHST- 2023/08/24 06:42 [medline]
PHST- 2023/08/10 06:42 [pubmed]
PHST- 2023/08/10 02:33 [entrez]
AID - 10.4155/tde-2023-0027 [doi]
PST - ppublish
SO  - Ther Deliv. 2023 Jul;14(7):459-472. doi: 10.4155/tde-2023-0027. Epub 2023 Aug 9.