PMID- 37559642
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230811
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 15
IP  - 7
DP  - 2023 Jul 31
TI  - Safety and feasibility of oesophageal ultrasound for the work-up of thoracic 
      malignancy in patients with respiratory impairment.
PG  - 3965-3973
LID - 10.21037/jtd-22-1705 [doi]
AB  - Biopsying lung tumours with endobronchial access in patients with respiratory 
      impairment is challenging. However, fine needle aspiration with the endobronchial 
      ultrasound-endoscope via the oesophagus (EUS-B-FNA) makes it possible to obtain 
      tissue samples without entering the airways. Safety of EUS-B-FNA in these 
      patients has not earlier been investigated prospectively. Therefore, this study 
      aimed at assessing feasibility and safety of EUS-B-FNA from centrally located 
      tumours suspected of thoracic malignancy in patients with respiratory 
      insufficiency. The study is a prospective observational study. Patients with 
      indication of EUS-B-FNA of centrally located tumours and respiratory impairment 
      defined as modified Medical Research Council (mMRC) dyspnoea scale score of >/=3, 
      saturation </=90% or need of continuous oxygen supply were included prospectively 
      in three centres. Any adverse events (AEs) were recorded during procedure and 
      1-hour recovery. AEs were defined as hypoxemia (saturation <90% or need for 
      increased oxygen supply) or any kind of events needing intervention. Late 
      procedure-related events were recorded during 30-day follow-up. Between April 1, 
      2020 and January 30, 2021, 16 patients were included. No severe AEs (SAEs) 
      occurred, but AEs were seen in 50% (n=8) and 13% (n=2) of the patients during 
      procedure and recovery respectively. AEs included hypoxemia corrected with 
      increased oxygen supply and in two cases reversal of sedation. Late 
      procedure-related events were seen in 13% (n=2) and included prolonged need of 
      oxygen and one infection treated with oral antibiotics. In this cohort, EUS-B-FNA 
      of centrally located tumours was safe and feasible in patients with respiratory 
      impairment, when examined in the bronchoscopy suite. A variety of mostly mild and 
      manageable complications may occur, a few even up to 30 days post-procedure.
CI  - 2023 Journal of Thoracic Disease. All rights reserved.
FAU - Christiansen, Ida Skovgaard
AU  - Christiansen IS
AD  - Respiratory Research Unit (PLUZ), Department of Respiratory Medicine, Zealand 
      University Hospital, Naestved, Denmark.
AD  - Department of Internal Medicine, Zealand University Hospital, Roskilde, Denmark.
FAU - Bodtger, Uffe
AU  - Bodtger U
AD  - Respiratory Research Unit (PLUZ), Department of Respiratory Medicine, Zealand 
      University Hospital, Naestved, Denmark.
AD  - Department of Internal Medicine, Zealand University Hospital, Roskilde, Denmark.
AD  - Institute of Regional Health Research, University of Southern Denmark, Odense, 
      Denmark.
FAU - Nessar, Rafi
AU  - Nessar R
AD  - Department of Internal Medicine, Zealand University Hospital, Roskilde, Denmark.
FAU - Salih, Goran Nadir
AU  - Salih GN
AD  - Department of Internal Medicine, Zealand University Hospital, Roskilde, Denmark.
FAU - Kolekar, Shailesh
AU  - Kolekar S
AD  - Department of Internal Medicine, Zealand University Hospital, Roskilde, Denmark.
FAU - Sidhu, Jatinder Sing
AU  - Sidhu JS
AD  - Respiratory Research Unit (PLUZ), Department of Respiratory Medicine, Zealand 
      University Hospital, Naestved, Denmark.
AD  - Department of Internal Medicine, Zealand University Hospital, Roskilde, Denmark.
FAU - Hoegholm, Asbjorn
AU  - Hoegholm A
AD  - Respiratory Research Unit (PLUZ), Department of Respiratory Medicine, Zealand 
      University Hospital, Naestved, Denmark.
FAU - Laursen, Christian B
AU  - Laursen CB
AD  - Odense Respiratory Research Unit (ODIN), Department of Clinical Research, 
      University of Southern Denmark, Odense, Denmark.
AD  - Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark.
FAU - Arshad, Arman
AU  - Arshad A
AD  - Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark.
FAU - Clementsen, Paul Frost
AU  - Clementsen PF
AD  - Respiratory Research Unit (PLUZ), Department of Respiratory Medicine, Zealand 
      University Hospital, Naestved, Denmark.
AD  - Department of Internal Medicine, Zealand University Hospital, Roskilde, Denmark.
AD  - Copenhagen Academy for Medical Education and Simulation (CAMES), University of 
      Copenhagen, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20230627
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC10407489
OTO - NOTNLM
OT  - Endobronchial ultrasound (EBUS)
OT  - interventional pulmonology
OT  - lung cancer
OT  - respiratory insufficiency
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at 
      https://jtd.amegroups.com/article/view/10.21037/jtd-22-1705/coif). ISC received 
      unrestricted research grants from the following funds: the Danish Respiratory 
      Society, Neye Fonden, Dagmar Marshalls Fond and Else og Mogens Wedell 
      Wedellsborgs Fond. The other authors have no conflicts of interest to declare.
EDAT- 2023/08/10 06:43
MHDA- 2023/08/10 06:44
PMCR- 2023/07/31
CRDT- 2023/08/10 03:55
PHST- 2022/12/07 00:00 [received]
PHST- 2023/06/02 00:00 [accepted]
PHST- 2023/08/10 06:44 [medline]
PHST- 2023/08/10 06:43 [pubmed]
PHST- 2023/08/10 03:55 [entrez]
PHST- 2023/07/31 00:00 [pmc-release]
AID - jtd-15-07-3965 [pii]
AID - 10.21037/jtd-22-1705 [doi]
PST - ppublish
SO  - J Thorac Dis. 2023 Jul 31;15(7):3965-3973. doi: 10.21037/jtd-22-1705. Epub 2023 
      Jun 27.