PMID- 37559872
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230811
IS  - 2352-3204 (Electronic)
IS  - 2352-3204 (Linking)
VI  - 24
DP  - 2023 Dec
TI  - Characterization of dynamical changes in vital signs during allogeneic human 
      umbilical cord-derived mesenchymal stem cells infusion.
PG  - 282-287
LID - 10.1016/j.reth.2023.07.007 [doi]
AB  - Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs), a kind of adult 
      stem cell, were studied for clinical applications in regenerative medicine. To 
      date, the safety evaluations of intravenous infusion of allogeneic hUC-MSCs were 
      focused on fever, infection, malignancy, and death. However, the characteristics 
      of dynamical changes in vital signs during hUC-MSCs infusion are largely unknown. 
      In this study, twenty participants with allogeneic hUC-MSCs transplanted (MSC 
      group) and twenty sex- and age-matched individuals with cardiovascular disease 
      who treated with the equal volume of 0.9% normal saline were recruited (NS 
      group). Heart rate, respiratory rate, oxygen saturation, systolic and diastolic 
      blood pressure, and temperature were monitored at intervals of 15 min during 
      infusion. Adverse events were recorded during infusion and within seven days 
      after infusion. No adverse events were observed during and after infusion in both 
      groups. Compared with the baseline, the mean systolic blood pressure (SBP) levels 
      were significantly decreased at 15 min, 30 min, 45 min and 60 min in the MSC 
      group (all P < 0.05) during infusion. In addition, SBP changed significantly from 
      baseline during hUC-MSCs infusion when compared with that of NS group (P < 0.05). 
      Repeated measures analysis of variance confirmed difference over time on the SBP 
      levels (P < 0.05). Our results showed that the process of allogeneic hUC-MSCs 
      intravenous infusion was safe and the vital signs were stable, whereas a slight 
      decrease in SBP was observed.
CI  - (c) 2023 The Japanese Society for Regenerative Medicine. Production and hosting by 
      Elsevier B.V.
FAU - Wang, Yue
AU  - Wang Y
AD  - Clinical Research Center for Cell Therapy, Shanghai East Hospital, School of 
      Medicine, Tongji University, Shanghai 200120, China.
FAU - Yu, Haiping
AU  - Yu H
AD  - Nursing Department, Shanghai East Hospital, School of Medicine, Tongji 
      University, Shanghai 200120, China.
FAU - Tang, Hongming
AU  - Tang H
AD  - Clinical Research Center for Cell Therapy, Shanghai East Hospital, School of 
      Medicine, Tongji University, Shanghai 200120, China.
AD  - Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, 
      School of Medicine, Tongji University, Shanghai 200120, China.
FAU - Zhu, Rong
AU  - Zhu R
AD  - Clinical Research Center for Cell Therapy, Shanghai East Hospital, School of 
      Medicine, Tongji University, Shanghai 200120, China.
FAU - Shi, Yiqi
AU  - Shi Y
AD  - Clinical Research Center for Cell Therapy, Shanghai East Hospital, School of 
      Medicine, Tongji University, Shanghai 200120, China.
FAU - Xu, Changqin
AU  - Xu C
AD  - Clinical Research Center for Cell Therapy, Shanghai East Hospital, School of 
      Medicine, Tongji University, Shanghai 200120, China.
FAU - Li, Yan
AU  - Li Y
AD  - Clinical Research Center for Cell Therapy, Shanghai East Hospital, School of 
      Medicine, Tongji University, Shanghai 200120, China.
FAU - Wang, Hua
AU  - Wang H
AD  - Catheterization Room, Seventh People's Hospital of Shanghai University of 
      Traditional Chinese Medicine, Shanghai 200137, China.
FAU - Chen, Yuanyuan
AU  - Chen Y
AD  - Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, 
      School of Medicine, Tongji University, Shanghai 200120, China.
FAU - Shen, Peichen
AU  - Shen P
AD  - Department of Medicine, Shanghai East Hospital, School of Medicine, Tongji 
      University, Shanghai 200120, China.
FAU - Xu, Jinfang
AU  - Xu J
AD  - Department of Health Statistics, Second Military Medical University, Shanghai 
      200433, China.
FAU - Wang, Congrong
AU  - Wang C
AD  - Department of Endocrinology & Metabolism, Shanghai Fourth People's Hospital, 
      School of Medicine, Tongji University, Shanghai 200434, China.
FAU - Liu, Zhongmin
AU  - Liu Z
AD  - Clinical Research Center for Cell Therapy, Shanghai East Hospital, School of 
      Medicine, Tongji University, Shanghai 200120, China.
AD  - Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, 
      School of Medicine, Tongji University, Shanghai 200120, China.
LA  - eng
PT  - Journal Article
DEP - 20230802
PL  - Netherlands
TA  - Regen Ther
JT  - Regenerative therapy
JID - 101709085
PMC - PMC10407816
OTO - NOTNLM
OT  - Allogeneic
OT  - Human umbilical cord
OT  - Infusion
OT  - Mesenchymal stem cells
OT  - Vital signs
COIS- The authors declare that they have no competing interests.
EDAT- 2023/08/10 06:43
MHDA- 2023/08/10 06:44
PMCR- 2023/08/02
CRDT- 2023/08/10 04:05
PHST- 2023/03/31 00:00 [received]
PHST- 2023/06/15 00:00 [revised]
PHST- 2023/07/26 00:00 [accepted]
PHST- 2023/08/10 06:44 [medline]
PHST- 2023/08/10 06:43 [pubmed]
PHST- 2023/08/10 04:05 [entrez]
PHST- 2023/08/02 00:00 [pmc-release]
AID - S2352-3204(23)00073-1 [pii]
AID - 10.1016/j.reth.2023.07.007 [doi]
PST - epublish
SO  - Regen Ther. 2023 Aug 2;24:282-287. doi: 10.1016/j.reth.2023.07.007. eCollection 
      2023 Dec.