PMID- 37560268 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230811 IS - 1880-4276 (Print) IS - 1883-2148 (Electronic) IS - 1880-4276 (Linking) VI - 39 IP - 4 DP - 2023 Aug TI - Heart failure is associated with increased risk of all-cause mortality after transvenous lead extraction: A systematic review and meta-analysis. PG - 596-606 LID - 10.1002/joa3.12880 [doi] AB - BACKGROUND: Transvenous lead extraction (TLE) is increasingly considered in cardiac implantable electronic device management. Heart failure (HF) might be associated with mortality risks after the TLE procedure. This study aims to assess mortality risk in HF patients undergoing TLE. METHOD: We searched MEDLINE and Embase databases from inception to June 2022 to identify articles that included patients with and without HF who underwent TLE, which reported mortality in both groups. The pooled effect size was calculated with a random-effects model and 95% CI to compare post-TLE mortality between the two groups. RESULTS: Eleven studies were included in the analysis. Each left ventricular ejection fraction (LVEF) increased by 1% was associated with reduced mortality by 2% (HR = 0.98, 95% CI: 0.97-0.99, I (2) = 74.9%, p < .01). The presence of HF compared to those without HF was associated with higher mortality rates (OR: 3.04, 95% CI: 2.56-3.61, I (2) = 0.0%, p < .531). There was a significant increase in the mortality rates in patients with New York Heart Association (NYHA) function class III (OR: 2.29, 95% CI: 1.29-4.06, I (2) = 0.0%, p = .498) and NYHA IV (OR: 8.5, 95% CI: 2.98-24.3, I (2) = 0.0%, p = .997). CONCLUSIONS: Our study found that post-TLE mortality decreases by 2% as LVEF increases by 1%, also mortality is higher in patients with NYHA III and IV. CI - (c) 2023 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of Japanese Heart Rhythm Society. FAU - Talaei, Fahimeh AU - Talaei F AUID- ORCID: 0000-0001-9236-4837 AD - Department of Internal Medicine McLaren Flint Hospital Flint Michigan USA. AD - Department of Cardiovascular Diseases Mayo Clinic Phoenix Arizona USA. FAU - Tan, Min C AU - Tan MC AUID- ORCID: 0000-0002-7682-8934 AD - Department of Cardiovascular Diseases Mayo Clinic Phoenix Arizona USA. AD - Department of Internal Medicine New York Medical College at Saint Michael's Medical Center Newark New Jersey USA. FAU - Trongtorsak, Angkawipa AU - Trongtorsak A AUID- ORCID: 0000-0003-1855-029X AD - Department of Cardiovascular Medicine Virginia Commonwealth University Richmond Virginia USA. FAU - Lee, Justin Z AU - Lee JZ AD - Department of Cardiovascular Diseases Mayo Clinic Phoenix Arizona USA. AD - Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA. FAU - Rattanawong, Pattara AU - Rattanawong P AUID- ORCID: 0000-0001-9419-5854 AD - Demoulas Center for Cardiac Arrhythmias Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA. LA - eng PT - Journal Article DEP - 20230606 PL - Japan TA - J Arrhythm JT - Journal of arrhythmia JID - 101263026 PMC - PMC10407184 OTO - NOTNLM OT - heart failure OT - left ventricular ejection fraction OT - mortality OT - transvenous lead extraction COIS- All authors have no relationships relevant to the contents of this paper to disclose. EDAT- 2023/08/10 06:43 MHDA- 2023/08/10 06:44 PMCR- 2023/06/06 CRDT- 2023/08/10 04:26 PHST- 2022/12/12 00:00 [received] PHST- 2023/05/17 00:00 [revised] PHST- 2023/05/24 00:00 [accepted] PHST- 2023/08/10 06:44 [medline] PHST- 2023/08/10 06:43 [pubmed] PHST- 2023/08/10 04:26 [entrez] PHST- 2023/06/06 00:00 [pmc-release] AID - JOA312880 [pii] AID - 10.1002/joa3.12880 [doi] PST - epublish SO - J Arrhythm. 2023 Jun 6;39(4):596-606. doi: 10.1002/joa3.12880. eCollection 2023 Aug.