PMID- 37560548
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230811
IS  - 1923-4163 (Electronic)
IS  - 1923-4155 (Print)
IS  - 1923-4155 (Linking)
VI  - 14
IP  - 7
DP  - 2023 Jul
TI  - Intravenous Immunoglobulin-Associated Severe Hemolytic Anemia.
PG  - 227-231
LID - 10.14740/jmc4126 [doi]
AB  - Intravenous immunoglobulin (IVIG) is used to treat immunodeficiency conditions, 
      neuro-immunological, infection-related, autoimmune, and inflammatory disorders 
      and is typically well tolerated. A hematological adverse reaction such as 
      hemolytic anemia and neutropenia is known to occur with IVIG, which is usually 
      transient and subclinical. However, severe hemolytic anemia is known to occur in 
      some cases. We present a case of a 66-year-old man who developed severe 
      symptomatic hemolytic anemia after receiving IVIG for acute inflammatory 
      demyelinating polyneuropathy (AIDP). The patient had known risk factors such as 
      non-O blood group, high cumulative dose of IVIG, and underlying autoimmune 
      condition, which would have put him at high risk for developing hemolytic anemia 
      after IVIG. Therefore, it is prudent for clinicians to have increased awareness 
      regarding the potential for severe hemolysis and closely monitor these patients 
      with risk factors after treatments to identify this adverse reaction before more 
      severe complications occur.
CI  - Copyright 2023, KC et al.
FAU - Kc, Ojbindra
AU  - Kc O
AUID- ORCID: 0000-0002-4669-2343
AD  - Department of Hospital Medicine, Faith Regional Health Services, Norfolk, NE, 
      USA.
FAU - Subedi, Ananta
AU  - Subedi A
AD  - Department of Hospital Medicine, Avera McKennan Hospital and University Health 
      Center, Sioux Falls, SD, USA.
FAU - Sharma, Rakshya
AU  - Sharma R
AD  - Department of Hospital Medicine, Avera McKennan Hospital and University Health 
      Center, Sioux Falls, SD, USA.
LA  - eng
PT  - Case Reports
DEP - 20230712
PL  - Canada
TA  - J Med Cases
JT  - Journal of medical cases
JID - 101551824
PMC - PMC10409536
OTO - NOTNLM
OT  - Hemolytic anemia
OT  - Intravenous immunoglobulin
OT  - Isoagglutinins
COIS- None to declare.
EDAT- 2023/08/10 06:43
MHDA- 2023/08/10 06:44
PMCR- 2023/07/01
CRDT- 2023/08/10 04:32
PHST- 2023/06/09 00:00 [received]
PHST- 2023/06/26 00:00 [accepted]
PHST- 2023/08/10 06:44 [medline]
PHST- 2023/08/10 06:43 [pubmed]
PHST- 2023/08/10 04:32 [entrez]
PHST- 2023/07/01 00:00 [pmc-release]
AID - 10.14740/jmc4126 [doi]
PST - ppublish
SO  - J Med Cases. 2023 Jul;14(7):227-231. doi: 10.14740/jmc4126. Epub 2023 Jul 12.