PMID- 37561282
OWN - NLM
STAT- Publisher
LR  - 20231009
IS  - 1993-0402 (Electronic)
IS  - 1672-0415 (Linking)
VI  - 29
IP  - 10
DP  - 2023 Oct
TI  - Acupuncture for Patients with Chronic Spontaneous Urticaria: A Randomized, 
      Sham-Controlled Pilot Trial.
PG  - 924-931
LID - 10.1007/s11655-023-3741-x [doi]
AB  - OBJECTIVE: To determine the feasibility of conducting a full-scale randomized 
      controlled trial (RCT) and investigate the basic information and safety of 
      acupuncture for patients with chronic spontaneous urticaria (CSU). METHODS: A 
      total of 80 participants with CSU from July 2018 to July 2019 were randomly 
      assigned to receive active acupuncture (n=41) on a fixed prescription of 
      acupoints or sham acupuncture (n=39) with superficial acupuncture on 
      non-acupuncture points through the completely randomized design. Patients in both 
      groups received 5 sessions per week for 2 weeks, and participants were followed 
      for a further 2 weeks. Feasibility was assessed by recruitment and randomization 
      rates, retention of participants, treatment protocol adherence, and the incidence 
      of adverse events (AEs). The clinical primary outcome was the changes from 
      baseline weekly urticaria activity scores (UAS7) after treatment at 2 weeks. 
      Secondary outcomes included the Visual Analogue Scale (VAS) score of itching 
      intensity, Dermatology Life Quality Index (DLQI), Hamilton Depression Scale 
      (HAMD), and Hamilton Anxiety Scale (HAMA). RESULTS: A total of 80 participants 
      were enrolled. The recruitment rate of 24.02%, randomization rate of 100%, a loss 
      rate of 6.25%, and no obvious AEs were observed in either group. The decrease 
      from baseline in the mean UAS7 total score at week 2 in the active acupuncture 
      group was -8.63 (95%CI, -11.78 to -5.49) and -6.21 (95%CI, -9.43 to -2.98) in the 
      sham acupuncture group for a between-group difference of -2.42 (95% CI, -6.93 to 
      2.07). The change in the DLQI, VAS of itching intensity, HAMA, and HAMD were a 
      slightly better improvement trend in the active acupuncture group than the sham 
      acupuncture group, but the between-group difference was not significant. 
      CONCLUSIONS: Active acupuncture had a better improvement trend in alleviating 
      symptoms, improving quality of life and regulating the mood of anxiety and 
      depression in patients with CSU than sham acupuncture. (Registration Nos. 
      AMCTR-ICR-18000190 and ChiCTR2100054776).
CI  - (c) 2023. The Chinese Journal of Integrated Traditional and Western Medicine Press 
      and Springer-Verlag GmbH Germany, part of Springer Nature.
FAU - Shi, Yun-Zhou
AU  - Shi YZ
AD  - Department of Acupuncture and Moxibustion, Chengdu University of Traditional 
      Chinese Medicine, Chengdu, 610075, China.
FAU - Yu, Shu-Guang
AU  - Yu SG
AD  - Department of Acupuncture and Moxibustion, Chengdu University of Traditional 
      Chinese Medicine, Chengdu, 610075, China.
FAU - Zheng, Hui
AU  - Zheng H
AD  - Department of Acupuncture and Moxibustion, Chengdu University of Traditional 
      Chinese Medicine, Chengdu, 610075, China.
FAU - Zheng, Qian-Hua
AU  - Zheng QH
AD  - Department of Acupuncture and Moxibustion, Chengdu University of Traditional 
      Chinese Medicine, Chengdu, 610075, China.
FAU - Zhou, Si-Yuan
AU  - Zhou SY
AD  - Department of Acupuncture and Moxibustion, Chengdu University of Traditional 
      Chinese Medicine, Chengdu, 610075, China.
FAU - Huang, Ying
AU  - Huang Y
AD  - Dermatology Department of Affiliated Hospital of Chengdu University of 
      Traditional Chinese Medicine, Chengdu, 610075, China.
FAU - Zhang, Lei-Xiao
AU  - Zhang LX
AD  - Department of Acupuncture and Moxibustion, Chengdu University of Traditional 
      Chinese Medicine, Chengdu, 610075, China.
FAU - Xiao, Xian-Jun
AU  - Xiao XJ
AD  - Department of Acupuncture and Moxibustion, Chengdu University of Traditional 
      Chinese Medicine, Chengdu, 610075, China.
FAU - Cao, Wei
AU  - Cao W
AD  - Department of Acupuncture and Moxibustion, Chengdu University of Traditional 
      Chinese Medicine, Chengdu, 610075, China.
FAU - Li, Ying
AU  - Li Y
AD  - Department of Acupuncture and Moxibustion, Chengdu University of Traditional 
      Chinese Medicine, Chengdu, 610075, China. liying@cdutcm.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230810
PL  - China
TA  - Chin J Integr Med
JT  - Chinese journal of integrative medicine
JID - 101181180
SB  - IM
OTO - NOTNLM
OT  - acupuncture
OT  - chronic spontaneous urticaria
OT  - randomized controlled trial
OT  - sham acupuncture
EDAT- 2023/08/10 12:43
MHDA- 2023/08/10 12:43
CRDT- 2023/08/10 11:16
PHST- 2023/03/15 00:00 [accepted]
PHST- 2023/08/10 12:43 [pubmed]
PHST- 2023/08/10 12:43 [medline]
PHST- 2023/08/10 11:16 [entrez]
AID - 10.1007/s11655-023-3741-x [pii]
AID - 10.1007/s11655-023-3741-x [doi]
PST - ppublish
SO  - Chin J Integr Med. 2023 Oct;29(10):924-931. doi: 10.1007/s11655-023-3741-x. Epub 
      2023 Aug 10.