PMID- 37561291
OWN - NLM
STAT- MEDLINE
DCOM- 20230908
LR  - 20230908
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 42
DP  - 2023 Sep
TI  - Comprehensive analysis between volatile organic compound (VOC) exposure and 
      female sex hormones: a cross-sectional study from NHANES 2013-2016.
PG  - 95828-95839
LID - 10.1007/s11356-023-29125-0 [doi]
AB  - There is growing evidence suggesting that exposure to volatile organic compounds 
      (VOCs) can pose significant health risks, including interference with the 
      function of the reproductive system. However, there has been a lack of research 
      focused on the impact of common environmental VOCs on the levels of sex hormones 
      in the general female population. In this study, we conducted a cross-sectional 
      analysis utilizing the database of the National Health and Nutrition Examination 
      Survey (NHANES, 2013-2016). A total of 2633 participants were included in this 
      study. The Pearson correlation model revealed the potential of co-exposure or 
      co-toxicity between benzene and 2,5-dimethylfuran. According to GLM models, we 
      discovered a significant positive association between blood levels of 
      2,5-dimethylfuran and benzene with testosterone levels in women. Subgroup 
      analysis further identified that the women with underweight and healthy weight 
      might be the high-risk subgroup. Bayesian kernel machine regression (BKMR) was 
      applied to further assess the univariate and bivariate exposure-response 
      relationships between multiple VOCs. Our research systemically formulated the 
      possible relationship between exposure to VOCs and female sex hormones, 
      indicating the role of VOCs as a risk factor for endocrine disruption, especially 
      benzene and 2,5-dimethylfuran. These findings have important implications for 
      public health and call for further investigation.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Wei, Chengcheng
AU  - Wei C
AD  - Department of Urology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Pan, Yao
AU  - Pan Y
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Fujian 
      Medical University, Quanzhou, 362000, China.
FAU - Zhang, Wenting
AU  - Zhang W
AD  - The First Clinical College, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan, 430030, China.
FAU - He, Qingliu
AU  - He Q
AD  - Department of Urology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
AD  - Department of Urology, The Second Affiliated Hospital of Fujian Medical 
      University, Quanzhou, 362000, China.
FAU - Chen, Zhaohui
AU  - Chen Z
AD  - Department of Urology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Zhang, Yuan
AU  - Zhang Y
AD  - Department of Nephrology, Clinical Research Center of Kidney Disease in Sichuan 
      Province, Sichuan Provincial People's Hospital, Medicine of School, University of 
      Electronic Science and Technology of China, Chengdu, 611731, China. 
      zhangyuansz@med.uestc.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230810
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Volatile Organic Compounds)
RN  - J64922108F (Benzene)
RN  - 0 (Air Pollutants)
RN  - 0 (Gonadal Steroid Hormones)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Volatile Organic Compounds/analysis
MH  - Cross-Sectional Studies
MH  - Environmental Exposure/analysis
MH  - Nutrition Surveys
MH  - Benzene/analysis
MH  - *Air Pollutants/analysis
MH  - Bayes Theorem
MH  - Gonadal Steroid Hormones/analysis
OTO - NOTNLM
OT  - 2,5-Dimethylfuran
OT  - Benzene
OT  - Estradiol (E2)
OT  - SHBG
OT  - Testosterone (TT)
OT  - Volatile organic compounds (VOCs)
EDAT- 2023/08/10 12:42
MHDA- 2023/09/08 06:42
CRDT- 2023/08/10 11:17
PHST- 2023/04/20 00:00 [received]
PHST- 2023/07/29 00:00 [accepted]
PHST- 2023/09/08 06:42 [medline]
PHST- 2023/08/10 12:42 [pubmed]
PHST- 2023/08/10 11:17 [entrez]
AID - 10.1007/s11356-023-29125-0 [pii]
AID - 10.1007/s11356-023-29125-0 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Sep;30(42):95828-95839. doi: 
      10.1007/s11356-023-29125-0. Epub 2023 Aug 10.