PMID- 37561906
OWN - NLM
STAT- MEDLINE
DCOM- 20230822
LR  - 20230909
IS  - 2576-6422 (Electronic)
IS  - 2576-6422 (Linking)
VI  - 6
IP  - 8
DP  - 2023 Aug 21
TI  - 3D-Printed PEEK/Silicon Nitride Scaffolds with a Triply Periodic Minimal Surface 
      Structure for Spinal Fusion Implants.
PG  - 3319-3329
LID - 10.1021/acsabm.3c00383 [doi]
AB  - The issue of spine-related disorders is a global healthcare concern that requires 
      effective solutions to restore normal spine functioning. Spinal fusion implants 
      have become a standard approach for this purpose, making it crucial to develop 
      biomaterials and structures that possess high osteogenic capacities and exhibit 
      mechanical properties and dynamic responses similar to those of the host bone. 
      This study focused on the fabrication of 3D-printed polyether ether 
      ketone/silicon nitride (PEEK/SiN) scaffolds with a triply periodic minimal 
      surface (TPMS) structure, which offers several advantages, such as a large 
      surface area and uniform stress distribution under load. The mechanical 
      properties and dynamic response of PEEK/SiN scaffolds with varying porosities 
      were evaluated through mechanical testing and finite element analysis. The 
      scaffold with 30% porosity exhibited a compressive strength (34.56 +/- 1.91 MPa) 
      and elastic modulus (734 +/- 64 MPa) similar to those of trabecular bone. In 
      addition, the scaffold demonstrated favorable damping properties. The biological 
      data revealed that incorporating silicon nitride into the PEEK scaffold 
      stimulated osteogenic differentiation. In light of these findings, it can be 
      inferred that PEEK/SiN TPMS scaffolds exhibit significant potential for use in 
      bone tissue engineering and represent a promising option as candidates for spinal 
      fusion implants.
FAU - Du, Xiaoyu
AU  - Du X
AUID- ORCID: 0000-0003-2532-731X
AD  - Institute for Biomechanics,ETH Zurich, Zurich 8093, Switzerland.
FAU - Ronayne, Sean
AU  - Ronayne S
AD  - SINTX Technologies, Inc., Salt Lake City, Utah 84119, United States.
FAU - Lee, Seunghun S
AU  - Lee SS
AUID- ORCID: 0000-0002-9654-8577
AD  - Institute for Biomechanics,ETH Zurich, Zurich 8093, Switzerland.
FAU - Hendry, Jackson
AU  - Hendry J
AD  - SINTX Technologies, Inc., Salt Lake City, Utah 84119, United States.
FAU - Hoxworth, Douglas
AU  - Hoxworth D
AD  - SINTX Technologies, Inc., Salt Lake City, Utah 84119, United States.
FAU - Bock, Ryan
AU  - Bock R
AD  - SINTX Technologies, Inc., Salt Lake City, Utah 84119, United States.
FAU - Ferguson, Stephen J
AU  - Ferguson SJ
AD  - Institute for Biomechanics,ETH Zurich, Zurich 8093, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230810
PL  - United States
TA  - ACS Appl Bio Mater
JT  - ACS applied bio materials
JID - 101729147
RN  - 31694-16-3 (polyetheretherketone)
RN  - QHB8T06IDK (silicon nitride)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 0 (Ketones)
SB  - IM
MH  - *Osteogenesis
MH  - *Spinal Fusion
MH  - Materials Testing
MH  - Polyethylene Glycols/chemistry
MH  - Ketones/chemistry
MH  - Printing, Three-Dimensional
PMC - PMC10445264
OTO - NOTNLM
OT  - 3D printing
OT  - PEEK
OT  - implants
OT  - silicon nitride
OT  - spine
COIS- The authors declare the following competing financial interest(s): Sean Ronayne, 
      Jackson Hendry, Douglas Hoxworth, and Ryan Bock are employees from SINTX 
      Technologies, Salt Lake City, Utah, USA.
EDAT- 2023/08/10 18:42
MHDA- 2023/08/22 06:42
PMCR- 2023/08/23
CRDT- 2023/08/10 14:43
PHST- 2023/08/22 06:42 [medline]
PHST- 2023/08/10 18:42 [pubmed]
PHST- 2023/08/10 14:43 [entrez]
PHST- 2023/08/23 00:00 [pmc-release]
AID - 10.1021/acsabm.3c00383 [doi]
PST - ppublish
SO  - ACS Appl Bio Mater. 2023 Aug 21;6(8):3319-3329. doi: 10.1021/acsabm.3c00383. Epub 
      2023 Aug 10.