PMID- 37562287
OWN - NLM
STAT- MEDLINE
DCOM- 20231009
LR  - 20231013
IS  - 1096-0341 (Electronic)
IS  - 0042-6822 (Linking)
VI  - 587
DP  - 2023 Oct
TI  - Molecular breeding of livestock for disease resistance.
PG  - 109862
LID - S0042-6822(23)00175-7 [pii]
LID - 10.1016/j.virol.2023.109862 [doi]
AB  - Animal infectious diseases pose a significant threat to the global agriculture 
      and biomedicine industries, leading to significant economic losses and public 
      health risks. The emergence and spread of viral infections such as African swine 
      fever virus (ASFV), porcine reproductive and respiratory syndrome virus (PRRSV), 
      porcine epidemic diarrhea virus (PEDV), and avian influenza virus (AIV) have 
      highlighted the need for innovative approaches to develop resilient and 
      disease-resistant animal populations. Gene editing technologies, such as 
      CRISPR/Cas9, offer a promising avenue for generating animals with enhanced 
      disease resistance. This review summarizes recent advances in molecular breeding 
      strategies for generating disease-resistant animals, focusing on the development 
      of disease-resistant livestock. We also highlight the potential applications of 
      genome-wide CRISPR/Cas9 library screening and base editors in producing precise 
      gene modified livestock for disease resistance in the future. Overall, gene 
      editing technologies have the potential to revolutionize animal breeding and 
      improve animal health and welfare.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Gao, Fei
AU  - Gao F
AD  - State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, 
      National Engineering Laboratory for Animal Breeding, Frontiers Science Center for 
      Molecular Design Breeding, China Agricultural University, Beijing, China; Sanya 
      Institute of China Agricultural University, Sanya, 572025, China.
FAU - Li, Pan
AU  - Li P
AD  - State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, 
      National Engineering Laboratory for Animal Breeding, Frontiers Science Center for 
      Molecular Design Breeding, China Agricultural University, Beijing, China; College 
      of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
FAU - Yin, Ye
AU  - Yin Y
AD  - State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, 
      National Engineering Laboratory for Animal Breeding, Frontiers Science Center for 
      Molecular Design Breeding, China Agricultural University, Beijing, China.
FAU - Du, Xuguang
AU  - Du X
AD  - State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, 
      National Engineering Laboratory for Animal Breeding, Frontiers Science Center for 
      Molecular Design Breeding, China Agricultural University, Beijing, China; Sanya 
      Institute of China Agricultural University, Sanya, 572025, China.
FAU - Cao, Gengsheng
AU  - Cao G
AD  - Henan Livestock Genome Editing and Biobreeding Engineering Research Center, 
      School of Life Sciences, Henan University, Kaifeng, 475004, China.
FAU - Wu, Sen
AU  - Wu S
AD  - State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, 
      National Engineering Laboratory for Animal Breeding, Frontiers Science Center for 
      Molecular Design Breeding, China Agricultural University, Beijing, China; Sanya 
      Institute of China Agricultural University, Sanya, 572025, China. Electronic 
      address: swu@cau.edu.cn.
FAU - Zhao, Yaofeng
AU  - Zhao Y
AD  - State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, 
      National Engineering Laboratory for Animal Breeding, Frontiers Science Center for 
      Molecular Design Breeding, China Agricultural University, Beijing, China. 
      Electronic address: yaofengzhao@cau.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230804
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
SB  - IM
MH  - Animals
MH  - Swine
MH  - Disease Resistance/genetics
MH  - Livestock
MH  - DNA Shuffling
MH  - *African Swine Fever Virus
MH  - *Porcine respiratory and reproductive syndrome virus
MH  - CRISPR-Cas Systems
OTO - NOTNLM
OT  - CRISPR/Cas9
OT  - Disease resistance
OT  - Livestock
OT  - Molecular breeding
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/08/11 00:42
MHDA- 2023/10/09 06:42
CRDT- 2023/08/10 18:10
PHST- 2023/06/02 00:00 [received]
PHST- 2023/07/27 00:00 [revised]
PHST- 2023/08/03 00:00 [accepted]
PHST- 2023/10/09 06:42 [medline]
PHST- 2023/08/11 00:42 [pubmed]
PHST- 2023/08/10 18:10 [entrez]
AID - S0042-6822(23)00175-7 [pii]
AID - 10.1016/j.virol.2023.109862 [doi]
PST - ppublish
SO  - Virology. 2023 Oct;587:109862. doi: 10.1016/j.virol.2023.109862. Epub 2023 Aug 4.