PMID- 37563647
OWN - NLM
STAT- MEDLINE
DCOM- 20230814
LR  - 20231120
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 22
IP  - 1
DP  - 2023 Aug 10
TI  - Elevated urine albumin creatinine ratio increases cardiovascular mortality in 
      coronary artery disease patients with or without type 2 diabetes mellitus: a 
      multicenter retrospective study.
PG  - 203
LID - 10.1186/s12933-023-01907-3 [doi]
LID - 203
AB  - BACKGROUND: Albuminuria has been suggested as an atherosclerotic risk factor 
      among the general population. However, whether this association will be amplified 
      in patients with coronary artery disease (CAD) is unknown. It is also unknown 
      whether diabetes mellitus confounds the association. We aim to analyse the 
      prognosis of elevated urine albumin creatinine ratio (uACR) in the CAD population 
      with or without type 2 diabetes mellitus (T2DM). METHODS: This multi-center 
      registry cohort study included 5,960 patients with CAD. Patients were divided 
      into T2DM and non-T2DM group, and baseline uACR levels were assessed on three 
      grades (low: uACR < 10 mg/g, middle: 10 mg/g </= uACR < 30 mg/g, and high: 
      uACR >/= 30 mg/g). The study endpoints were cardiovascular mortality and all-cause 
      mortality. RESULTS: During the median follow-up of 2.2 [1.2-3.1] years, 310 
      (5.2%) patients died, of which 236 (4.0%) patients died of cardiovascular 
      disease. CAD patients with elevated uACR had a higher risk of cardiovascular 
      mortality (middle: HR, 2.32; high: HR, 3.22) than those with low uACR, as well as 
      all-cause mortality. Elevated uACR increased nearly 1.5-fold risk of 
      cardiovascular mortality (middle: HR, 2.33; high: HR, 2.34) among patients 
      without T2DM, and increased 1.5- fold to 3- fold risk of cardiovascular mortality 
      in T2DM patients (middle: HR, 2.49; high: HR, 3.98). CONCLUSIONS: Even mildly 
      increased uACR could increase the risk of cardiovascular mortality in patients 
      with CAD, especially when combined with T2DM.
CI  - (c) 2023. BioMed Central Ltd., part of Springer Nature.
FAU - Lin, Xueqin
AU  - Lin X
AD  - Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, 
      China.
FAU - Song, Wei
AU  - Song W
AD  - Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, 
      China.
FAU - Zhou, Yang
AU  - Zhou Y
AD  - Department of Cardiology, Guangdong Provincial People's Hospital, Guangdong 
      Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou, 
      510080, China.
AD  - Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease 
      Prevention, Guangdong Provincial People's Hospital, Guangdong Cardiovascular 
      Institute, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
FAU - Gao, Yuwei
AU  - Gao Y
AD  - Jinan university, Zhuhai people's hospital, Guangzhou, 510100, China.
FAU - Wang, Yani
AU  - Wang Y
AD  - Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, 
      China.
FAU - Wang, Yun
AU  - Wang Y
AD  - Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, 
      China.
FAU - Liu, Yuchen
AU  - Liu Y
AD  - Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, 
      China.
FAU - Deng, Lin
AU  - Deng L
AD  - Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, 
      China.
FAU - Liao, Yin
AU  - Liao Y
AD  - Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, 
      China.
FAU - Wu, Bo
AU  - Wu B
AD  - Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, 
      China.
FAU - Chen, Shiqun
AU  - Chen S
AD  - Global Health Research Center, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Science, Guangzhou, 510100, China. shiqunchen@126.com.
FAU - Chen, Liling
AU  - Chen L
AD  - Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, 
      China. chenliling19790206@163.com.
FAU - Fang, Yong
AU  - Fang Y
AD  - Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, 
      China. fangyong7008fjly@163.com.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20230810
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
RN  - AYI8EX34EU (Creatinine)
RN  - 0 (Albumins)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis/epidemiology
MH  - *Coronary Artery Disease/diagnosis/complications
MH  - Creatinine/urine
MH  - Retrospective Studies
MH  - Cohort Studies
MH  - *Cardiovascular Diseases/epidemiology
MH  - Albumins
MH  - Albuminuria/epidemiology
PMC - PMC10416404
OTO - NOTNLM
OT  - Coronary artery disease
OT  - Diabetes mellitus
OT  - Mortality
OT  - Urine albumin creatinine ratio
COIS- The authors have declared that no conflict of interest exists.
EDAT- 2023/08/11 00:41
MHDA- 2023/08/14 06:41
PMCR- 2023/08/10
CRDT- 2023/08/10 23:45
PHST- 2023/05/09 00:00 [received]
PHST- 2023/06/29 00:00 [accepted]
PHST- 2023/08/14 06:41 [medline]
PHST- 2023/08/11 00:41 [pubmed]
PHST- 2023/08/10 23:45 [entrez]
PHST- 2023/08/10 00:00 [pmc-release]
AID - 10.1186/s12933-023-01907-3 [pii]
AID - 1907 [pii]
AID - 10.1186/s12933-023-01907-3 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2023 Aug 10;22(1):203. doi: 10.1186/s12933-023-01907-3.