PMID- 37565311
OWN - NLM
STAT- MEDLINE
DCOM- 20230825
LR  - 20230828
IS  - 1759-9679 (Electronic)
IS  - 1759-9660 (Linking)
VI  - 15
IP  - 33
DP  - 2023 Aug 24
TI  - Effects of targeted lung cancer drugs on cardiomyocytes studied by atomic force 
      microscopy.
PG  - 4077-4084
LID - 10.1039/d3ay00784g [doi]
AB  - The epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKIs) has 
      become one of the important targeted drugs for the treatment of non-small cell 
      lung cancer (NSCLC). But the cardiac adverse events (AEs) related to the EGFR-TKI 
      treatment occur frequently. And the cases of TKI-associated cardiac AEs remain 
      poorly understood. In order to study the effects of EGFR-TKIs on cardiomyocytes, 
      atomic force microscopy (AFM) was used to measure and analyze the physical 
      properties of cardiomyocytes under the actions of three drugs (gefitinib, 
      afatinib and osimertinib) with different concentrations. By comparing the height, 
      adhesion, Young's modulus, the amplitude and the time of the contraction and 
      relaxation process, it was found that the changes of the mechanical properties of 
      cells were well correlated with the symptoms of AEs, such as cardiomyocyte 
      hypertrophy, QT prolongation, atrial fibrillation, ejection fraction reductions, 
      and cardiac failure. In addition, osimertinib has the most obvious effect on 
      cardiomyocytes at a low concentration, and gefitinib has the greatest effect with 
      the increase of concentration, while afatinib has the least effect on 
      cardiomyocytes. This provides a new method for screening drugs and exploring the 
      principle of action in the process of cancer treatment at the cellular level.
FAU - Cheng, Can
AU  - Cheng C
AD  - International Research Centre for Nano Handling and Manufacturing of China, 
      Changchun University of Science and Technology, Changchun 130022, China. 
      wangz@cust.edu.cn.
AD  - Centre for Opto/Bio-Nano Measurement and Manufacturing, Zhongshan Institute of 
      Changchun University of Science and Technology, Zhongshan 528437, China.
AD  - Ministry of Education Key Laboratory for Cross-Scale Micro and Nano 
      Manufacturing, Changchun University of Science and Technology, Changchun 130022, 
      China.
FAU - Wang, Shuwei
AU  - Wang S
AD  - Affiliated Hospital of Jilin Medical University, Jilin City, Jilin, China.
FAU - Dong, Jianjun
AU  - Dong J
AD  - International Research Centre for Nano Handling and Manufacturing of China, 
      Changchun University of Science and Technology, Changchun 130022, China. 
      wangz@cust.edu.cn.
AD  - Centre for Opto/Bio-Nano Measurement and Manufacturing, Zhongshan Institute of 
      Changchun University of Science and Technology, Zhongshan 528437, China.
AD  - Ministry of Education Key Laboratory for Cross-Scale Micro and Nano 
      Manufacturing, Changchun University of Science and Technology, Changchun 130022, 
      China.
FAU - Zhang, Shengli
AU  - Zhang S
AD  - International Research Centre for Nano Handling and Manufacturing of China, 
      Changchun University of Science and Technology, Changchun 130022, China. 
      wangz@cust.edu.cn.
AD  - Centre for Opto/Bio-Nano Measurement and Manufacturing, Zhongshan Institute of 
      Changchun University of Science and Technology, Zhongshan 528437, China.
AD  - Ministry of Education Key Laboratory for Cross-Scale Micro and Nano 
      Manufacturing, Changchun University of Science and Technology, Changchun 130022, 
      China.
FAU - Yu, Dongliang
AU  - Yu D
AD  - International Research Centre for Nano Handling and Manufacturing of China, 
      Changchun University of Science and Technology, Changchun 130022, China. 
      wangz@cust.edu.cn.
AD  - Centre for Opto/Bio-Nano Measurement and Manufacturing, Zhongshan Institute of 
      Changchun University of Science and Technology, Zhongshan 528437, China.
FAU - Wang, Zuobin
AU  - Wang Z
AUID- ORCID: 0000-0002-7168-0918
AD  - International Research Centre for Nano Handling and Manufacturing of China, 
      Changchun University of Science and Technology, Changchun 130022, China. 
      wangz@cust.edu.cn.
AD  - Centre for Opto/Bio-Nano Measurement and Manufacturing, Zhongshan Institute of 
      Changchun University of Science and Technology, Zhongshan 528437, China.
AD  - Ministry of Education Key Laboratory for Cross-Scale Micro and Nano 
      Manufacturing, Changchun University of Science and Technology, Changchun 130022, 
      China.
AD  - JR3CN & IRAC, University of Bedfordshire, Luton LU1 3JU, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230824
PL  - England
TA  - Anal Methods
JT  - Analytical methods : advancing methods and applications
JID - 101519733
RN  - 3C06JJ0Z2O (osimertinib)
RN  - 41UD74L59M (Afatinib)
RN  - S65743JHBS (Gefitinib)
RN  - 0 (Protein Kinase Inhibitors)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Humans
MH  - *Lung Neoplasms/drug therapy/chemically induced
MH  - *Carcinoma, Non-Small-Cell Lung/chemically induced/drug therapy
MH  - Afatinib/therapeutic use
MH  - Gefitinib/therapeutic use
MH  - Myocytes, Cardiac/metabolism
MH  - Microscopy, Atomic Force
MH  - Protein Kinase Inhibitors/adverse effects
MH  - ErbB Receptors/metabolism/therapeutic use
MH  - *Antineoplastic Agents/adverse effects
MH  - Lung/metabolism
EDAT- 2023/08/11 06:42
MHDA- 2023/08/25 06:43
CRDT- 2023/08/11 04:43
PHST- 2023/08/25 06:43 [medline]
PHST- 2023/08/11 06:42 [pubmed]
PHST- 2023/08/11 04:43 [entrez]
AID - 10.1039/d3ay00784g [doi]
PST - epublish
SO  - Anal Methods. 2023 Aug 24;15(33):4077-4084. doi: 10.1039/d3ay00784g.