PMID- 37566392
OWN - NLM
STAT- MEDLINE
DCOM- 20230904
LR  - 20230918
IS  - 1029-2330 (Electronic)
IS  - 1026-7158 (Linking)
VI  - 31
IP  - 8
DP  - 2023 Sep
TI  - In vivo application of magnetic molecularly imprinted polymer in rheumatoid 
      arthritis rat model.
PG  - 878-888
LID - 10.1080/1061186X.2023.2247584 [doi]
AB  - A magnetic molecularly imprinted polymer (MMIP) was synthesised and tested for an 
      in vivo rheumatoid arthritis (RA) rat model. Magnetite coated with mesoporous 
      silica (Fe(2)O(3)@mSi) was used as core for surface imprinting, dopamine was used 
      as monomer and methotrexate (MTX) was loaded directly during polymerisation. The 
      amount of MTX loaded on MMIPs reached 201.165 +/- 0.315 micromol/g. Characterisation of 
      the polymers was done via SEM, TEM, and FTIR. The pharmacological effect of the 
      selected MMIP was evaluated in a Complete Freund's Adjuvant (CFA) induced 
      arthritis rat model where a 3D magnet bearing construct was designed for targeted 
      delivery of MMIPs. The parameters evaluated were the change in paw edoema, paw 
      diameter, gait score, and animal's weight. Results revealed a tendency of MMIP to 
      significantly improve the measured parameters which was confirmed with 
      histopathological findings. In conclusion, the improvement in the arthritic signs 
      associated with MMIP treatment compared to free MTX, indicated successful 
      targeting of MMIPs to the site of inflammation.
FAU - Soliman, Mariam
AU  - Soliman M
AD  - Pharmaceutical Chemistry Department, Faculty of Pharmacy and Biotechnology, 
      German University in Cairo, Cairo, Egypt.
AD  - Department of Chemistry, Faculty of Biotechnology, The German International 
      University in Cairo, Cairo, Egypt.
FAU - Shanan, Nagwan
AU  - Shanan N
AD  - Pharmacology and Toxicology Department, Faculty of Pharmacy and Biotechnology, 
      German University in Cairo, Cairo, Egypt.
AD  - School of Life and Medical Sciences, University of Hertfordshire Hosted By Global 
      Academic Foundation, Cairo, Egypt.
FAU - Eissa, Gamal
AU  - Eissa G
AD  - Materials Engineering Department, Faculty of Engineering and Materials Science, 
      German University in Cairo, Cairo, Egypt.
FAU - Mizaikoff, Boris
AU  - Mizaikoff B
AD  - Institute of Analytical and Bioanalytical Chemistry, Ulm University, Ulm, 
      Germany.
AD  - Hahn-Schickard, Ulm, Germany.
FAU - El Gohary, Nesrine A
AU  - El Gohary NA
AD  - Pharmaceutical Chemistry Department, Faculty of Pharmacy and Biotechnology, 
      German University in Cairo, Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20230817
PL  - England
TA  - J Drug Target
JT  - Journal of drug targeting
JID - 9312476
RN  - 0 (Molecularly Imprinted Polymers)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Molecularly Imprinted Polymers/therapeutic use
MH  - *Arthritis, Rheumatoid/drug therapy
MH  - Methotrexate/pharmacology/therapeutic use
MH  - Inflammation
MH  - Magnetic Phenomena
OTO - NOTNLM
OT  - Magnetic molecularly imprinted polymer
OT  - methotrexate
OT  - polydopamine
OT  - rheumatoid arthritis
OT  - targeted drug delivery
EDAT- 2023/08/11 12:42
MHDA- 2023/09/04 06:42
CRDT- 2023/08/11 11:23
PHST- 2023/09/04 06:42 [medline]
PHST- 2023/08/11 12:42 [pubmed]
PHST- 2023/08/11 11:23 [entrez]
AID - 10.1080/1061186X.2023.2247584 [doi]
PST - ppublish
SO  - J Drug Target. 2023 Sep;31(8):878-888. doi: 10.1080/1061186X.2023.2247584. Epub 
      2023 Aug 17.