PMID- 37566466
OWN - NLM
STAT- MEDLINE
DCOM- 20231117
LR  - 20231117
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Linking)
VI  - 21
IP  - 9
DP  - 2023 Nov
TI  - RS3480 Polymorphism of FNDC5/Irisin Is Associated with Type 2 Diabetes Mellitus 
      in Maya-Mestizo Women.
PG  - 503-508
LID - 10.1089/met.2023.0042 [doi]
AB  - Objective: To investigate the possible association between rs3480 and rs16835198 
      of the fibronectin type III domain containing 5 (FNDC5)/Irisin and their 
      haplotypes with the presence of type 2 diabetes mellitus (T2DM) in Maya-Mestizo 
      women. Methods: We studied 547 postmenopausal women of Maya-Mestizo origin. The 
      diagnosis of T2DM was based on the criteria of the American Diabetes Association. 
      DNA was obtained from blood leukocytes. rs3480 and rs16835198 of FNDC5/Irisin 
      were studied using real-time polymerase chain reaction allelic discrimination. 
      Deviations from Hardy-Weinberg equilibrium and alleles differences, as well as 
      genotype frequencies between groups, were assessed by chi(2) tests. Using logistic 
      regression analysis, the odds ratio and 95% confidence intervals were calculated 
      to estimate the association between both polymorphisms of FNDC5/Irisin and the 
      presence of T2DM. Pairwise linkage disequilibrium between polymorphisms was 
      calculated by direct correlation r(2), and haplotype analysis was conducted. 
      Results: We found that the G-allele of rs3480, as well as under a dominant model, 
      this polymorphism was significantly associated with T2DM (P = 0.028 and 
      P = 0.003, respectively). Besides, one haplotype was associated with T2DM 
      (P = 0.035). Conclusions: Our results suggest that the FNDC5/Irisin rs3480, and 
      one haplotype formed by rs3480 and rs16835198 were associated with the risk of 
      presenting T2DM in Maya-Mestizo women.
FAU - Canto-Cetina, Thelma
AU  - Canto-Cetina T
AUID- ORCID: 0000-0002-5952-375X
AD  - Laboratorio de Biologia de la Reproduccion, Centro de Investigaciones Regionales 
      "Dr. Hideyo Noguchi," Universidad Autonoma de Yucatan, Merida, Mexico.
FAU - Silva-Nicanor, Diana
AU  - Silva-Nicanor D
AD  - Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, 
      Instituto Politecnico Nacional, Ciudad de Mexico, Mexico.
FAU - Coral-Vazquez, Ramon Mauricio
AU  - Coral-Vazquez RM
AUID- ORCID: 0000-0001-6126-2002
AD  - Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, 
      Instituto Politecnico Nacional, Ciudad de Mexico, Mexico.
AD  - Subdireccion de Ensenanza e Investigacion, Centro Medico Nacional "20 de 
      Noviembre," Instituto de Seguridad y Servicios Sociales de los Trabajadores del 
      Estado, Ciudad de Mexico, Mexico.
FAU - Cano-Martinez, Luis Javier
AU  - Cano-Martinez LJ
AUID- ORCID: 0000-0002-1473-6014
AD  - Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, 
      Instituto Politecnico Nacional, Ciudad de Mexico, Mexico.
AD  - Subdireccion de Ensenanza e Investigacion, Centro Medico Nacional "20 de 
      Noviembre," Instituto de Seguridad y Servicios Sociales de los Trabajadores del 
      Estado, Ciudad de Mexico, Mexico.
FAU - Canto, Patricia
AU  - Canto P
AUID- ORCID: 0000-0002-1891-480X
AD  - Unidad de Investigacion en Obesidad, Facultad de Medicina, Universidad Nacional 
      Autonoma de Ciudad de Mexico, Ciudad de Mexico, Mexico.
AD  - Subdireccion de Investigacion Clinica, Direccion de Investigacion, Instituto 
      Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran," Ciudad de Mexico, 
      Mexico.
LA  - eng
PT  - Journal Article
DEP - 20230809
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
RN  - 0 (Fibronectins)
RN  - 0 (Transcription Factors)
RN  - 0 (FNDC5 protein, human)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - Fibronectins/genetics
MH  - Polymorphism, Single Nucleotide
MH  - Genotype
MH  - Haplotypes
MH  - Transcription Factors
OTO - NOTNLM
OT  - FNDC5/Irisin
OT  - Maya-Mestizo women
OT  - T2DM
OT  - haplotypes
OT  - polymorphisms
EDAT- 2023/08/11 18:42
MHDA- 2023/11/17 15:31
CRDT- 2023/08/11 12:03
PHST- 2023/11/17 15:31 [medline]
PHST- 2023/08/11 18:42 [pubmed]
PHST- 2023/08/11 12:03 [entrez]
AID - 10.1089/met.2023.0042 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2023 Nov;21(9):503-508. doi: 10.1089/met.2023.0042. 
      Epub 2023 Aug 9.