PMID- 37566939
OWN - NLM
STAT- MEDLINE
DCOM- 20230922
LR  - 20230922
IS  - 1532-8198 (Electronic)
IS  - 1092-9134 (Linking)
VI  - 66
DP  - 2023 Oct
TI  - High grade tumor budding is associated with poor survival in pathologic stage I 
      lung adenocarcinoma.
PG  - 152188
LID - S1092-9134(23)00086-2 [pii]
LID - 10.1016/j.anndiagpath.2023.152188 [doi]
AB  - AIM: Tumor budding is a significant prognostic parameter that has been related to 
      aggressive behavior in early-stage tumors of various origins. The aim of this 
      study was to evaluate the clinicopathological significance of tumor budding in 
      pathologic stage (pStage) I lung adenocarcinomas. METHODS: This study comprised 
      107 patients who underwent curative resection for pStage I lung adenocarcinomas 
      at our hospital between December 2010 and January 2016. We examined tumor budding 
      on routine hematoxylin and eosin (H&E) slides from resected specimens. Tumors 
      were categorized into two groups based on the degree of tumor budding: low grade 
      (grade 0-1) and high grade (grade 2-3). We evaluated the relationship between 
      tumor budding and overall survival (OS), disease-free survival (DFS) and 
      clinicopathological parameters. RESULTS: There is a significant difference 
      (p = 0.002) between the 5-year DFS rates of the high-grade and the low-grade 
      tumor budding group, which were 70 % and 90 %, respectively. High-grade tumor 
      budding positive patients from the same pathological stage (p < 0.001; HR = 2.93 
      [1.51-5.68]) and clinical stage (p = 0.002) had poorer cumulative survival rates 
      than low grade tumor budding positive patients. High grade tumor budding was 
      positively associated with spread through air spaces (STAS) (p < 0 0.001), 
      lymphovascular invasion (LVI) (p < 0.001), tumor necrosis (p < 0.001), high 
      SUVmax value (SUVmax>3.0) (p < 0.001), and tumor size >20 mm (p = 0.024). 
      High-grade tumor budding was significant prognostic factor of OS (p < 0.006) and 
      DFS (p < 0.001) on univariate Cox regression hazard model analysis. However, it 
      did not show significance in the multivariate analysis (p > 0.05). CONCLUSIONS: 
      High-grade tumor budding is an independent prognostic factor and associated with 
      adverse clinicopathological features and poor survival rates. We proposed that 
      high-grade tumor budding should be recognized as a new prognostic parameter and 
      will be beneficial in predicting the clinical course in pStage I lung 
      adenocarcinomas.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Gurcay, Nesrin
AU  - Gurcay N
AD  - Department of Pathology, Ankara Ataturk Chest Diseases and Thoracic Surgery 
      Training and Research Hospital, Turkey. Electronic address: 
      nesrin_gurcay@hotmail.com.
FAU - Acar, Leyla Nesrin
AU  - Acar LN
AD  - Department of Thoracic Surgery, Ankara Ataturk Chest Diseases and Thoracic 
      Surgery Training and Research Hospital, Turkey.
FAU - Unal, Tuba Dilay Kokenek
AU  - Unal TDK
AD  - Department of Pathology, Faculty of Medicine, Ankara Yildirim Beyazit University, 
      Ankara, Turkey.
FAU - Tanrikulu, Fatma Benli
AU  - Tanrikulu FB
AD  - Department of Pathology, Ankara Ataturk Chest Diseases and Thoracic Surgery 
      Training and Research Hospital, Turkey.
FAU - Biner, Inci Uslu
AU  - Biner IU
AD  - Department of Nuclear Medicine, Ankara Ataturk Chest Diseases and Thoracic 
      Surgery Training and Research Hospital, Turkey.
FAU - Bulut, Sertan
AU  - Bulut S
AD  - Department of Chest Disease, Ankara Ataturk Chest Diseases and Thoracic Surgery 
      Training and Research Hospital, Turkey.
FAU - Baykal, Husnu
AU  - Baykal H
AD  - Department of Chest Disease, Ankara Ataturk Chest Diseases and Thoracic Surgery 
      Training and Research Hospital, Turkey.
FAU - Demirag, Funda
AU  - Demirag F
AD  - Department of Pathology, Ankara Ataturk Chest Diseases and Thoracic Surgery 
      Training and Research Hospital, Turkey.
FAU - Findik, Gokturk
AU  - Findik G
AD  - Department of Thoracic Surgery, Ankara Ataturk Chest Diseases and Thoracic 
      Surgery Training and Research Hospital, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20230803
PL  - United States
TA  - Ann Diagn Pathol
JT  - Annals of diagnostic pathology
JID - 9800503
SB  - IM
MH  - Humans
MH  - Neoplasm Staging
MH  - Neoplasm Invasiveness/pathology
MH  - *Adenocarcinoma of Lung/pathology
MH  - Prognosis
MH  - Retrospective Studies
MH  - *Lung Neoplasms/surgery/pathology
OTO - NOTNLM
OT  - Lung adenocarcinoma
OT  - Prognosis
OT  - Tumor budding
EDAT- 2023/08/11 18:42
MHDA- 2023/09/22 06:42
CRDT- 2023/08/11 18:00
PHST- 2023/05/19 00:00 [received]
PHST- 2023/08/01 00:00 [revised]
PHST- 2023/08/01 00:00 [accepted]
PHST- 2023/09/22 06:42 [medline]
PHST- 2023/08/11 18:42 [pubmed]
PHST- 2023/08/11 18:00 [entrez]
AID - S1092-9134(23)00086-2 [pii]
AID - 10.1016/j.anndiagpath.2023.152188 [doi]
PST - ppublish
SO  - Ann Diagn Pathol. 2023 Oct;66:152188. doi: 10.1016/j.anndiagpath.2023.152188. 
      Epub 2023 Aug 3.