PMID- 37567484 OWN - NLM STAT- MEDLINE DCOM- 20231216 LR - 20240306 IS - 1878-5492 (Electronic) IS - 0966-3274 (Linking) VI - 81 DP - 2023 Dec TI - Diagnostic clues in a stem cell transplant patient manifested with chronic central nervous system GVHD and IRIS. PG - 101916 LID - S0966-3274(23)00133-8 [pii] LID - 10.1016/j.trim.2023.101916 [doi] AB - Transplant physicians should be aware of the immune deviation-related clinical conditions as allogeneic hematopoietic stem cell transplantation is widely used for the treatment of patients with malignant and non-malignant disorders. Neurological manifestations and graft-versus-host disease (GVHD) may commonly develop in transplant recipients. However, overlapping clinical immunological conditions may lead to diagnostic challenges. Herein, we discussed the differential diagnosis of a patient with immune reconstitution inflammatory syndrome (IRIS) developing on the basis of chronic GVHD. CI - Copyright (c) 2023 Elsevier B.V. All rights reserved. FAU - Boga, Can AU - Boga C AD - Adana Adult Bone Marrow Transplantation Center, Department of Hematology, Baskent University Faculty of Medicine, Ankara, Turkiye. Electronic address: drcanboga@hotmail.com. FAU - Eliacik, Eylem AU - Eliacik E AD - Adana Adult Bone Marrow Transplantation Center, Department of Hematology, Baskent University Faculty of Medicine, Ankara, Turkiye. FAU - Yalcin, Cigdem AU - Yalcin C AD - Department of Radiology, Baskent University Faculty of Medicine, Ankara, Turkiye. FAU - Kocer, Nazim Emrah AU - Kocer NE AD - Department of Pathology, Baskent University Faculty of Medicine, Ankara, Turkiye. FAU - Durdag, Emre AU - Durdag E AD - Department of Neurosurgery, Baskent University Faculty of Medicine, Ankara, Turkiye. FAU - Gereklioglu, Cigdem AU - Gereklioglu C AD - Department of Family Medicine, Baskent University Faculty of Medicine, Ankara, Turkiye. LA - eng PT - Case Reports DEP - 20230809 PL - Netherlands TA - Transpl Immunol JT - Transplant immunology JID - 9309923 SB - IM MH - Humans MH - *Hematopoietic Stem Cell Transplantation/adverse effects MH - Stem Cell Transplantation MH - *Graft vs Host Disease/therapy MH - Transplantation, Homologous OTO - NOTNLM OT - Graft-versus-host disease OT - Immune reconstitution inflammatory syndrome OT - Neuroinflammation OT - Stem cell transplantation COIS- Declaration of Competing Interest There is no conflict of interest. EDAT- 2023/08/12 10:41 MHDA- 2023/12/17 09:46 CRDT- 2023/08/11 19:27 PHST- 2023/06/23 00:00 [received] PHST- 2023/08/08 00:00 [accepted] PHST- 2023/12/17 09:46 [medline] PHST- 2023/08/12 10:41 [pubmed] PHST- 2023/08/11 19:27 [entrez] AID - S0966-3274(23)00133-8 [pii] AID - 10.1016/j.trim.2023.101916 [doi] PST - ppublish SO - Transpl Immunol. 2023 Dec;81:101916. doi: 10.1016/j.trim.2023.101916. Epub 2023 Aug 9.