PMID- 37568143
OWN - NLM
STAT- MEDLINE
DCOM- 20230814
LR  - 20231120
IS  - 1476-511X (Electronic)
IS  - 1476-511X (Linking)
VI  - 22
IP  - 1
DP  - 2023 Aug 11
TI  - The association between exposure to volatile organic compounds and serum lipids 
      in the US adult population.
PG  - 129
LID - 10.1186/s12944-023-01895-z [doi]
LID - 129
AB  - BACKGROUND AND AIM: Epidemiological evidence on the relationship between exposure 
      to volatile organic compounds (VOCs), both single and mixed, and serum lipid 
      levels is limited, and their relationship remains unclear. Our study aimed to 
      investigate the associations of exposure to VOCs with serum lipid levels in the 
      US adult population. METHODS AND RESULTS: The study examined the association of 
      16 VOC levels (2-methylhippuric acid, 3- and 4-methylhippuric acid, 
      N-acetyl-S-(2-carbamoylethyl)-L-cysteine, 
      N-acetyl-S-(N-methylcarbamoyl)-L-cysteine, 2-aminothiazoline-4-carboxylic acid, 
      N-acetyl-S-(benzyl)-L-cysteine, N-acetyl-S-(n-propyl)-L-cysteine, 
      N-acetyl-S-(2-carboxyethyl)-L-cysteine, N-acetyl-S-(2-cyanoethyl)-L-cysteine, 
      N-acetyl-S-(3,4-dihydroxybutyl)-L-cysteine, 
      N-acetyl-S-(2-hydroxypropyl)-L-cysteine. N-Acetyl-S-(3-hydroxypropyl)-L-cysteine, 
      mandelic acid, N-acetyl-S-(4-hydroxy-2-butenyl)-L-cysteine, phenylglyoxylic acid 
      and N-acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine) with total cholesterol 
      (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL) and 
      high-density lipoprotein cholesterol (HDL) using data from the National Health 
      and Nutrition Examination Survey (NHANES) between 2011 and 2015, and a total of 
      1410 adults were enrolled. The association was evaluated by Bayesian kernel 
      machine regression (BKMR), multiple linear regression and weighted quantile sum 
      (WQS) regression. In BKMR analysis, exposure to VOCs is positively correlated 
      with levels of TC, TG, and LDL-C. However, statistical significance was observed 
      only for the impact on TG. Our linear regression analysis and WQS regression 
      generally support the BKMR results. Several VOCs were positively associated with 
      serum lipid profiles (e.g., the ln-transformed level of mandelic acid (MA) 
      displayed an increase in estimated changes of 7.01 (95% CIs: 2.78, 11.24) mg/dL 
      for TC level), even after the effective number of tests for multiple testing 
      (P < 0.05). CONCLUSIONS: Exposure to VOCs was associated with serum lipids, and 
      more studies are needed to confirm these findings.
CI  - (c) 2023. BioMed Central Ltd., part of Springer Nature.
FAU - Chen, Wen-Yu
AU  - Chen WY
AUID- ORCID: 0000-0001-8108-1778
AD  - Cardiovascular Medicine Department, Nanchang University Second Affiliated 
      Hospital, Nanchang, Jiangxi, 330006, China. cwy_maxine@163.com.
FAU - Fu, Yan-Peng
AU  - Fu YP
AD  - Second Clinical Medical College of Nanchang University, Nanchang, Jiangxi, 
      330006, China.
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Second Affiliated 
      Hospital of Nanchang University, No.1 Minde Road, Nanchang, China.
FAU - Tu, Hui
AU  - Tu H
AD  - Nusring Department, Nanchang University Second Affiliated Hospital, Nanchang, 
      Jiangxi, 330006, China.
FAU - Zhong, Wen
AU  - Zhong W
AD  - Cardiovascular Medicine Department, Nanchang University Second Affiliated 
      Hospital, Nanchang, Jiangxi, 330006, China.
FAU - Zhou, Liang
AU  - Zhou L
AD  - Cardiovascular Medicine Department, Nanchang University Second Affiliated 
      Hospital, Nanchang, Jiangxi, 330006, China.
LA  - eng
PT  - Journal Article
DEP - 20230811
PL  - England
TA  - Lipids Health Dis
JT  - Lipids in health and disease
JID - 101147696
RN  - NH496X0UJX (mandelic acid)
RN  - 0 (Volatile Organic Compounds)
RN  - 0 (Triglycerides)
RN  - 0 (Cholesterol, HDL)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - *Volatile Organic Compounds
MH  - Nutrition Surveys
MH  - Bayes Theorem
MH  - Triglycerides
MH  - Cholesterol, HDL
MH  - Acetylcysteine
PMC - PMC10422774
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Lipids
OT  - NHANES
OT  - Volatile Organic Compounds
COIS- All authors declare no conflicts of interest.
EDAT- 2023/08/12 10:42
MHDA- 2023/08/14 06:43
PMCR- 2023/08/11
CRDT- 2023/08/11 23:34
PHST- 2023/06/22 00:00 [received]
PHST- 2023/07/31 00:00 [accepted]
PHST- 2023/08/14 06:43 [medline]
PHST- 2023/08/12 10:42 [pubmed]
PHST- 2023/08/11 23:34 [entrez]
PHST- 2023/08/11 00:00 [pmc-release]
AID - 10.1186/s12944-023-01895-z [pii]
AID - 1895 [pii]
AID - 10.1186/s12944-023-01895-z [doi]
PST - epublish
SO  - Lipids Health Dis. 2023 Aug 11;22(1):129. doi: 10.1186/s12944-023-01895-z.