PMID- 37569498
OWN - NLM
STAT- MEDLINE
DCOM- 20230814
LR  - 20230814
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 15
DP  - 2023 Jul 28
TI  - The Potential of Bile Acids as Biomarkers for Metabolic Disorders.
LID - 10.3390/ijms241512123 [doi]
LID - 12123
AB  - Bile acids (BAs) are well known to facilitate the absorption of dietary fat and 
      fat-soluble molecules. These unique steroids also function by binding to the 
      ubiquitous cell membranes and nuclear receptors. As chemical signals in gut-liver 
      axis, the presence of metabolic disorders such as nonalcoholic fatty liver 
      disease (NAFLD), type 2 diabetes mellitus (T2DM), and even tumors have been 
      reported to be closely related to abnormal levels of BAs in the blood and fecal 
      metabolites of patients. Thus, the gut microbiota interacting with BAs and 
      altering BA metabolism are critical in the pathogenesis of numerous chronic 
      diseases. This review intends to summarize the mechanistic links between 
      metabolic disorders and BAs in gut-liver axis, and such stage-specific BA 
      perturbation patterns may provide clues for developing new auxiliary diagnostic 
      means.
FAU - Yin, Chang
AU  - Yin C
AUID- ORCID: 0009-0009-3603-9322
AD  - State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal 
      Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
FAU - Zhong, Ruqing
AU  - Zhong R
AUID- ORCID: 0000-0003-0494-6699
AD  - State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal 
      Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
FAU - Zhang, Weidong
AU  - Zhang W
AD  - State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal 
      Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
FAU - Liu, Lei
AU  - Liu L
AD  - State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal 
      Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
FAU - Chen, Liang
AU  - Chen L
AD  - State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal 
      Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
FAU - Zhang, Hongfu
AU  - Zhang H
AD  - State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal 
      Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
LA  - eng
GR  - U22A20515/National Natural Science Foundation of China/
GR  - 32202709/National Natural Science Foundation of China/
GR  - Y2023QC09/Youth Innovation of Chinese Academy of Agricultural Sciences/
GR  - CAAS-ZDRW202006-02/Agricultural Science and Technology Innovation Program/
GR  - ASTIPIAS07/Agricultural Science and Technology Innovation Program/
PT  - Journal Article
PT  - Review
DEP - 20230728
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Bile Acids and Salts)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Bile Acids and Salts/metabolism
MH  - *Diabetes Mellitus, Type 2/metabolism
MH  - Liver/metabolism
MH  - *Non-alcoholic Fatty Liver Disease/metabolism
MH  - Biomarkers/metabolism
PMC - PMC10418921
OTO - NOTNLM
OT  - bile acid metabolism
OT  - diagnostic biomarker
OT  - dysbiosis
OT  - enterohepatic circulation
OT  - gut microbiota
OT  - metabolic disorders
COIS- The authors declare no conflict of interest.
EDAT- 2023/08/12 10:50
MHDA- 2023/08/14 06:42
PMCR- 2023/07/28
CRDT- 2023/08/12 01:09
PHST- 2023/06/24 00:00 [received]
PHST- 2023/07/15 00:00 [revised]
PHST- 2023/07/22 00:00 [accepted]
PHST- 2023/08/14 06:42 [medline]
PHST- 2023/08/12 10:50 [pubmed]
PHST- 2023/08/12 01:09 [entrez]
PHST- 2023/07/28 00:00 [pmc-release]
AID - ijms241512123 [pii]
AID - ijms-24-12123 [pii]
AID - 10.3390/ijms241512123 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Jul 28;24(15):12123. doi: 10.3390/ijms241512123.