PMID- 37571283
OWN - NLM
STAT- MEDLINE
DCOM- 20230814
LR  - 20230814
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 15
IP  - 15
DP  - 2023 Jul 27
TI  - Dietary Polyphenols Remodel DNA Methylation Patterns of NRF2 in Chronic Disease.
LID - 10.3390/nu15153347 [doi]
LID - 3347
AB  - The nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor 
      crucial in regulating cellular homeostasis and apoptosis. The NRF2 gene has been 
      implicated in various biological activities, including antioxidant, 
      anti-inflammatory, and anticancer properties. NRF2 can be regulated genetically 
      and epigenetically at the transcriptional, post-transcriptional, and 
      translational levels. Although DNA methylation is one of the critical biological 
      processes vital for gene expression, sometimes, anomalous methylation patterns 
      result in the dysregulation of genes and consequent diseases and disorders. 
      Several studies have reported promoter hypermethylation downregulated NRF2 
      expression and its downstream targets. In contrast to the unalterable nature of 
      genetic patterns, epigenetic changes can be reversed, opening up new 
      possibilities in developing therapies for various metabolic disorders and 
      diseases. This review discusses the current state of the NRF2-mediated 
      antioxidative and chemopreventive activities of several natural phytochemicals, 
      including sulforaphane, resveratrol, curcumin, luteolin, corosolic acid, 
      apigenin, and most other compounds that have been found to activate NRF2. This 
      epigenetic reversal of hypermethylated NRF2 states provides new opportunities for 
      research into dietary phytochemistry that affects the human epigenome and the 
      possibility for cutting-edge approaches to target NRF2-mediated signaling to 
      prevent chronic disorders.
FAU - Divyajanani, Srinivasaragavan
AU  - Divyajanani S
AD  - Department of Biotechnology, School of Bioengineering, SRM Institute of Science 
      and Technology, Kattankulathur 603210, Tamil Nadu, India.
FAU - Harithpriya, Kannan
AU  - Harithpriya K
AD  - Department of Biotechnology, School of Bioengineering, SRM Institute of Science 
      and Technology, Kattankulathur 603210, Tamil Nadu, India.
FAU - Ganesan, Kumar
AU  - Ganesan K
AUID- ORCID: 0000-0002-3198-6066
AD  - School of Chinese Medicine, LKS Faculty of Medicine, University of Hong Kong, 3 
      Sassoon Road, Hong Kong, China.
FAU - Ramkumar, Kunka Mohanram
AU  - Ramkumar KM
AUID- ORCID: 0000-0001-5450-902X
AD  - Department of Biotechnology, School of Bioengineering, SRM Institute of Science 
      and Technology, Kattankulathur 603210, Tamil Nadu, India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230727
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Antioxidants)
RN  - 0 (Polyphenols)
SB  - IM
MH  - Humans
MH  - *DNA Methylation
MH  - *NF-E2-Related Factor 2/genetics/metabolism
MH  - Oxidative Stress/genetics
MH  - Epigenesis, Genetic
MH  - Antioxidants/pharmacology/metabolism
MH  - Chronic Disease
MH  - Polyphenols/pharmacology
PMC - PMC10420661
OTO - NOTNLM
OT  - DNMTs
OT  - dietary polyphenols
OT  - epigenetics
OT  - hypermethylation
OT  - hypomethylation
OT  - nuclear factor erythroid 2-related factor 2
OT  - phytochemicals
COIS- The authors declare no conflict of interest.
EDAT- 2023/08/12 10:53
MHDA- 2023/08/14 06:42
PMCR- 2023/07/27
CRDT- 2023/08/12 01:21
PHST- 2023/06/15 00:00 [received]
PHST- 2023/07/17 00:00 [revised]
PHST- 2023/07/25 00:00 [accepted]
PHST- 2023/08/14 06:42 [medline]
PHST- 2023/08/12 10:53 [pubmed]
PHST- 2023/08/12 01:21 [entrez]
PHST- 2023/07/27 00:00 [pmc-release]
AID - nu15153347 [pii]
AID - nutrients-15-03347 [pii]
AID - 10.3390/nu15153347 [doi]
PST - epublish
SO  - Nutrients. 2023 Jul 27;15(15):3347. doi: 10.3390/nu15153347.