PMID- 37571359
OWN - NLM
STAT- MEDLINE
DCOM- 20231124
LR  - 20231124
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 15
IP  - 15
DP  - 2023 Aug 2
TI  - The Joint Effects of Bisphenols and Iodine Exposure on Thyroid during Pregnancy.
LID - 10.3390/nu15153422 [doi]
LID - 3422
AB  - The aim of this research was to study the combined effects of bisphenols and 
      iodine exposure on the thyroid gland during pregnancy. We included 162 pregnant 
      women from a cohort established in Shanghai. Urinary concentrations of bisphenol 
      A, bisphenol B(BPB), bisphenol C(BPC), bisphenol F, bisphenol S, and bisphenol 
      AF(BPAF) were examined. Bayesian kernel machine regression (BKMR) and quantile 
      g-computation models were used. The geometric means of BPA, BPB, BPC, BPF, BPS, 
      BPAF, and SigmaBPs levels in urine were 3.03, 0.24, 2.66, 0.36, 0.26, 0.72, and 7.55 
      mug/g creatinine, respectively. We observed a positive trend in the cumulative 
      effects of BPs and iodine on serum triiodothyronine (FT3) and free thyroxine 
      (FT4), as well as a U-shaped dose-response relationship between BPs and the 
      probability of occurrence of thyroperoxidase autoantibody positivity in women 
      with low urinary iodine concentration. In addition, a synergistic effect on the 
      probability of occurrence of thyroid autoantibody positivity was observed between 
      BPF and BPB, as well as between BPC and BPAF in this study. There were adverse 
      health effects on the thyroid after co-exposure to BPs and iodine. Even if 
      pregnant women were exposed to lower levels of BPs, women with iodine deficiency 
      remained vulnerable to thyroid autoimmune disease.
FAU - Lu, Wei
AU  - Lu W
AD  - Division of Health Risk Factors Monitoring and Control, Shanghai Municipal Center 
      for Disease Control and Prevention, Shanghai 200336, China.
FAU - Sun, Zhuo
AU  - Sun Z
AD  - Division of Health Risk Factors Monitoring and Control, Shanghai Municipal Center 
      for Disease Control and Prevention, Shanghai 200336, China.
FAU - Wang, Zhengyuan
AU  - Wang Z
AD  - Division of Health Risk Factors Monitoring and Control, Shanghai Municipal Center 
      for Disease Control and Prevention, Shanghai 200336, China.
FAU - Qu, Mengying
AU  - Qu M
AD  - Division of Health Risk Factors Monitoring and Control, Shanghai Municipal Center 
      for Disease Control and Prevention, Shanghai 200336, China.
FAU - Shi, Zehuan
AU  - Shi Z
AD  - Division of Health Risk Factors Monitoring and Control, Shanghai Municipal Center 
      for Disease Control and Prevention, Shanghai 200336, China.
FAU - Song, Qi
AU  - Song Q
AD  - Division of Health Risk Factors Monitoring and Control, Shanghai Municipal Center 
      for Disease Control and Prevention, Shanghai 200336, China.
FAU - Shen, Liping
AU  - Shen L
AD  - Division of Health Risk Factors Monitoring and Control, Shanghai Municipal Center 
      for Disease Control and Prevention, Shanghai 200336, China.
FAU - Mai, Shupeng
AU  - Mai S
AD  - Division of Health Risk Factors Monitoring and Control, Shanghai Municipal Center 
      for Disease Control and Prevention, Shanghai 200336, China.
FAU - Wang, Yuan
AU  - Wang Y
AD  - Division of Health Risk Factors Monitoring and Control, Shanghai Municipal Center 
      for Disease Control and Prevention, Shanghai 200336, China.
FAU - Hong, Xinyu
AU  - Hong X
AD  - Division of Health Risk Factors Monitoring and Control, Shanghai Municipal Center 
      for Disease Control and Prevention, Shanghai 200336, China.
FAU - Zang, Jiajie
AU  - Zang J
AD  - Division of Health Risk Factors Monitoring and Control, Shanghai Municipal Center 
      for Disease Control and Prevention, Shanghai 200336, China.
LA  - eng
GR  - DIC2019-03/the Dietary Nutrition Research and Education Foundation of Danone 
      Nutrition Center/
GR  - CNS-YUM2021-95/the Chinese Nutrition Society Yum Brands Health Fund/
GR  - No. 2020-8/Top Young Talents in Shanghai/
PT  - Journal Article
DEP - 20230802
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Air Pollutants, Occupational)
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Phenols)
RN  - MLT3645I99 (bisphenol A)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Humans
MH  - Female
MH  - Pregnancy
MH  - Air Pollutants, Occupational
MH  - *Benzhydryl Compounds/urine
MH  - *Phenols/urine
MH  - *Maternal Exposure/adverse effects
MH  - *Thyroid Gland/drug effects
MH  - China
MH  - Triiodothyronine/blood/drug effects
MH  - Thyroxine/blood/drug effects
MH  - Adult
PMC - PMC10421451
OTO - NOTNLM
OT  - bisphenols
OT  - iodine
OT  - thyroid
COIS- The authors declare no conflict of interest.
EDAT- 2023/08/12 10:50
MHDA- 2023/08/14 06:42
PMCR- 2023/08/02
CRDT- 2023/08/12 01:21
PHST- 2023/06/26 00:00 [received]
PHST- 2023/07/23 00:00 [revised]
PHST- 2023/07/30 00:00 [accepted]
PHST- 2023/08/14 06:42 [medline]
PHST- 2023/08/12 10:50 [pubmed]
PHST- 2023/08/12 01:21 [entrez]
PHST- 2023/08/02 00:00 [pmc-release]
AID - nu15153422 [pii]
AID - nutrients-15-03422 [pii]
AID - 10.3390/nu15153422 [doi]
PST - epublish
SO  - Nutrients. 2023 Aug 2;15(15):3422. doi: 10.3390/nu15153422.