PMID- 37572023
OWN - NLM
STAT- MEDLINE
DCOM- 20230814
LR  - 20230815
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 51
IP  - 8
DP  - 2023 Aug
TI  - Nomogram for predicting survival of patients with gastric cancer and multiple 
      primary malignancies: a real-world retrospective analysis using the Surveillance, 
      Epidemiology and End Results database.
PG  - 3000605231187944
LID - 10.1177/03000605231187944 [doi]
LID - 03000605231187944
AB  - OBJECTIVES: Gastric cancer combined with multiple primary malignancies (GCM) is 
      increasingly common. This study investigated GCM clinical features and survival 
      time. METHODS: Patients with GCM and GC only (GCO) were selected from the 
      Surveillance, Epidemiology and End Results (SEER) database. Survival was compared 
      between GCM and GCO groups using propensity score matching. Then, the GCM group 
      was divided into a training cohort and a validation cohort. These cohorts were 
      used to establish a nomogram for survival prediction in patients with GCM. 
      RESULTS: Survival time was significantly longer in the GCM group than in the GCO 
      group. All-subsets regression was used to identify four variables for nomogram 
      establishment: age, gastric cancer sequence, N stage, and surgery. The 
      concordance index and time-dependent receiver operating characteristic curve 
      indicated that the nomogram had favorable discriminative ability. Calibration 
      plots of predicted and actual probabilities showed good consistency in both the 
      training and validation cohorts. Decision curve analysis and risk stratification 
      showed that the nomogram was clinically useful; it had favorable discriminative 
      ability to recognize patients with different levels of risk. CONCLUSIONS: 
      Compared with GCO, GCM is a relatively indolent malignancy. The nomogram 
      developed in this study can help clinicians to assess GCM prognosis.
FAU - Mei, Linhang
AU  - Mei L
AD  - Department of Surgical Oncology, Taizhou Hospital of Zhejiang Province affiliated 
      to Wenzhou Medical University, Taizhou, Zhejiang, China.
FAU - Feng, Jie
AU  - Feng J
AD  - Department of Traumatic Orthopedics, Taizhou Hospital of Zhejiang Province 
      affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China.
FAU - Zhao, Lingdan
AU  - Zhao L
AD  - Department of General Practice, Taizhou Hospital of Zhejiang Province affiliated 
      to Wenzhou Medical University, Taizhou, Zhejiang, China.
FAU - Zheng, Xiaokang
AU  - Zheng X
AD  - Emergency Department, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou 
      Medical University, Taizhou, Zhejiang, China.
FAU - Li, Xiao
AU  - Li X
AUID- ORCID: 0000-0002-9404-595X
AD  - Department of General Surgery, Taizhou Hospital of Zhejiang Province affiliated 
      to Wenzhou Medical University, Taizhou, Zhejiang, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
SB  - IM
MH  - Humans
MH  - *Stomach Neoplasms/epidemiology
MH  - Nomograms
MH  - Retrospective Studies
MH  - Patients
MH  - *Neoplasms, Multiple Primary
MH  - Prognosis
PMC - PMC10423457
OTO - NOTNLM
OT  - Nomogram
OT  - SEER database
OT  - gastric cancer
OT  - multiple primary malignancies
OT  - prognosis
OT  - propensity score
OT  - receiver operating characteristic curve
OT  - stomach neoplasm
OT  - survival
COIS- The authors declare that there is no conflict of interest.
EDAT- 2023/08/13 00:43
MHDA- 2023/08/14 06:43
PMCR- 2023/08/12
CRDT- 2023/08/12 07:22
PHST- 2023/08/14 06:43 [medline]
PHST- 2023/08/13 00:43 [pubmed]
PHST- 2023/08/12 07:22 [entrez]
PHST- 2023/08/12 00:00 [pmc-release]
AID - 10.1177_03000605231187944 [pii]
AID - 10.1177/03000605231187944 [doi]
PST - ppublish
SO  - J Int Med Res. 2023 Aug;51(8):3000605231187944. doi: 10.1177/03000605231187944.