PMID- 37572607
OWN - NLM
STAT- MEDLINE
DCOM- 20230831
LR  - 20230831
IS  - 1873-3336 (Electronic)
IS  - 0304-3894 (Linking)
VI  - 459
DP  - 2023 Oct 5
TI  - Immune and inflammatory responses of human macrophages, dendritic cells, and 
      T-cells in presence of micro- and nanoplastic of different types and sizes.
PG  - 132194
LID - S0304-3894(23)01477-2 [pii]
LID - 10.1016/j.jhazmat.2023.132194 [doi]
AB  - Environmental pollution by microplastics (MPs) is a growing concern regarding 
      their impact on aquatic and terrestrial systems and human health. Typical 
      exposure routes of MPs are dermal contact, digestion, and inhalation. Recent in 
      vitro and in vivo studies observed alterations in immunity after MPs exposure, 
      but systemic studies using primary human immune cells are scarce. In our 
      investigation, we addressed the effect of polystyrene (PS) and poly methyl 
      methacrylate (PMMA) in three different sizes (50-1100 nm) as well as 
      amino-modified PS (PS-NH(2); 50 nm) on cells of the adaptive and innate immune 
      system. T-cells isolated from human peripheral blood mononuclear cells (PBMCs) 
      were least affected regarding the cytotoxicity but displayed increased activation 
      marker expression after 72 h, and strongly modulated cytokine secretion patterns. 
      Conversely, phagocytic dendritic cells and macrophages derived from isolated 
      monocytes were highly sensitive to pristine MPs. Their marker expression 
      suggested a downregulation of the inflammatory phenotypes indicative of M2 
      macrophage induction after MPs exposure for 24 h. Our results showed that even 
      pristine MPs affected immune cell function and inflammatory phenotype dependent 
      on MPs polymers, size, and immune cell type.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Wolff, Christina M
AU  - Wolff CM
AD  - ZIK plasmatis, Leibniz Institute for Plasma Science and Technology (INP), 
      Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.
FAU - Singer, Debora
AU  - Singer D
AD  - ZIK plasmatis, Leibniz Institute for Plasma Science and Technology (INP), 
      Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.
FAU - Schmidt, Anke
AU  - Schmidt A
AD  - ZIK plasmatis, Leibniz Institute for Plasma Science and Technology (INP), 
      Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.
FAU - Bekeschus, Sander
AU  - Bekeschus S
AD  - ZIK plasmatis, Leibniz Institute for Plasma Science and Technology (INP), 
      Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany; Clinic and Policlinic for 
      Dermatology and Venerology, Rostock University Medical Center, Strempelstr. 13, 
      18057 Rostock, Germany. Electronic address: sander.bekeschus@inp-greifswald.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230731
PL  - Netherlands
TA  - J Hazard Mater
JT  - Journal of hazardous materials
JID - 9422688
RN  - 0 (Microplastics)
RN  - 0 (Plastics)
RN  - 0 (Polystyrenes)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Humans
MH  - *Microplastics/toxicity
MH  - Plastics/toxicity
MH  - Leukocytes, Mononuclear
MH  - T-Lymphocytes/metabolism
MH  - Macrophages/metabolism
MH  - Polystyrenes/toxicity/metabolism
MH  - Dendritic Cells
MH  - *Water Pollutants, Chemical/toxicity
OTO - NOTNLM
OT  - Monocytes
OT  - NKT cells
OT  - PBMC
OT  - PMMA
OT  - Polystyrene
OT  - Toxicity
COIS- Declaration of Competing Interest The authors declare no competing interests with 
      regard to the publication of this article.
EDAT- 2023/08/13 00:43
MHDA- 2023/08/31 06:42
CRDT- 2023/08/12 18:10
PHST- 2023/06/21 00:00 [received]
PHST- 2023/07/21 00:00 [revised]
PHST- 2023/07/29 00:00 [accepted]
PHST- 2023/08/31 06:42 [medline]
PHST- 2023/08/13 00:43 [pubmed]
PHST- 2023/08/12 18:10 [entrez]
AID - S0304-3894(23)01477-2 [pii]
AID - 10.1016/j.jhazmat.2023.132194 [doi]
PST - ppublish
SO  - J Hazard Mater. 2023 Oct 5;459:132194. doi: 10.1016/j.jhazmat.2023.132194. Epub 
      2023 Jul 31.