PMID- 37573044
OWN - NLM
STAT- MEDLINE
DCOM- 20231102
LR  - 20231104
IS  - 1998-3646 (Electronic)
IS  - 0255-0857 (Linking)
VI  - 45
DP  - 2023 Sep-Oct
TI  - Prevalence of R5 and X4-Tropic strains in HIV-1 Infected bangladeshi population.
PG  - 100377
LID - S0255-0857(23)00093-2 [pii]
LID - 10.1016/j.ijmmb.2023.100377 [doi]
AB  - PURPOSE: HIV uses CD4 as main receptor to infect a cell. Also, it uses coreceptor 
      (CCR5 or CXCR4) as a surrogate marker. In Bangladesh, nearly 50% of the 
      identified strains are subtype C. In this study, we have examined viral genotypic 
      co-receptor tropism in Bangladesh People Living with HIV (PLHIV). METHODS: We 
      identified a co-receptor on V3 sequences of the HIV env gene. The online 
      Geno2pheno tools was used. The threshold limit of a 10% false-positive rate was 
      used. Samples from HIV-infected individuals aged 5-50 years were taken from which 
      we obtained a good quality of 55 sequences. The viral tropism frequency in 
      different circulating Bangladeshi HIV subtypes was analyzed using SPSS. RESULTS: 
      Above two third of the samples, (61.8%; 34 of 55) were HIV-1 subtype C. We 
      identified 83.6% (46 of 55) of the samples were R5tropic, 16.4% (9 of 55) as X4 
      tropic, HIV-1 strains. The R5 tropic strains among key population infected with 
      different HIV-1 subtype in the Bangladeshi population is common. CONCLUSIONS: 
      This finding can help with suitable drug selection in reverse-transcriptase (RT) 
      or protease (PR) drug-resistance strains.
CI  - Copyright (c) 2023 Indian Association of Medical Microbiologists. Published by 
      Elsevier B.V. All rights reserved.
FAU - Sarker, Md Safiullah
AU  - Sarker MS
AD  - Virology Laboratory, International Centre for Diarrhoeal Diseases Research, 
      Bangladesh (ICDDR,B), Mohakhali, Dhaka-1212, Bangladesh. Electronic address: 
      ssarker@icddrb.org.
LA  - eng
PT  - Journal Article
DEP - 20230524
PL  - United States
TA  - Indian J Med Microbiol
JT  - Indian journal of medical microbiology
JID - 8700903
SB  - IM
MH  - Humans
MH  - *HIV Infections/epidemiology
MH  - *HIV-1/genetics
MH  - Prevalence
MH  - *HIV Seropositivity
MH  - Viral Tropism
OTO - NOTNLM
OT  - Bangladesh
OT  - CCR5
OT  - CXCR4
OT  - HIV
COIS- Declaration of competing interest None.
EDAT- 2023/08/13 00:43
MHDA- 2023/08/13 00:44
CRDT- 2023/08/12 20:57
PHST- 2022/10/20 00:00 [received]
PHST- 2023/04/03 00:00 [revised]
PHST- 2023/04/16 00:00 [accepted]
PHST- 2023/08/13 00:44 [medline]
PHST- 2023/08/13 00:43 [pubmed]
PHST- 2023/08/12 20:57 [entrez]
AID - S0255-0857(23)00093-2 [pii]
AID - 10.1016/j.ijmmb.2023.100377 [doi]
PST - ppublish
SO  - Indian J Med Microbiol. 2023 Sep-Oct;45:100377. doi: 10.1016/j.ijmmb.2023.100377. 
      Epub 2023 May 24.