PMID- 37573144
OWN - NLM
STAT- MEDLINE
DCOM- 20230908
LR  - 20230928
IS  - 1540-8159 (Electronic)
IS  - 0147-8389 (Linking)
VI  - 46
IP  - 9
DP  - 2023 Sep
TI  - Atrial paced rhythm and heart rate-dependent worsening of left atrial and 
      ventricular function.
PG  - 1116-1123
LID - 10.1111/pace.14800 [doi]
AB  - BACKGROUND AND AIM OF THE STUDY: The response to the increase in heart rate (HR) 
      could be characterized by failure in both left ventricular (LV) and left atrial 
      (LA) functions. This study aimed to evaluate the relationship between the 
      increase in paced HR and the changes in LV and LA functions, assessed by 
      two-dimensional speckle tracking analysis. METHODS: In a group of patients with 
      an implantable cardioverter defibrillator (ICD) or pacemaker, the atrial paced 
      rhythm was progressively increased from 60 to 70, from 70 to 80, and from 80 to 
      90 beats per minute (bpm). For each paced HR, using two-dimensional speckle 
      tracking analysis, LA reservoir (LAr), LA conduit (LAc), LA contraction (LAct), 
      and LV global longitudinal strain (LV-GLS) were evaluated every 10 bpm. RESULTS: 
      Of the 45 patients enrolled, a significant reduction in LAr was observed at 
      higher HR. However, when the patients were dichotomized according to the 
      HR-related response of LV-GLS, the worsening of LAr was observed in those with 
      LV-GLS worsening and not in those without (maximum LAR absolute changes 
      -2.7 +/- 7.2% vs. +2.7 +/- 7.2%, respectively, p .028). Moreover, the worsening of LA 
      and LV strain measures was associated with an increase in the estimated filling 
      pressures. CONCLUSIONS: In patients with atrial paced rhythm, the increase in HR 
      could be associated with worsening of LA and LV functions, as assessed by 
      two-dimensional speckle tracking analyses. These results offer new data on 
      HR-related atrioventricular function and could be useful for guiding the optimal 
      HR responsiveness of the implanted devices.
CI  - (c) 2023 The Authors. Pacing and Clinical Electrophysiology published by Wiley 
      Periodicals LLC.
FAU - Corbo, Maria Delia
AU  - Corbo MD
AD  - Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
FAU - Terlizzi, Vito di
AU  - Terlizzi VD
AD  - Cardiology Unit, University Polyclinic Hospital of Foggia, Foggia, Italy.
FAU - Barone, Roberta
AU  - Barone R
AD  - Cardiology Unit, University Polyclinic Hospital of Foggia, Foggia, Italy.
FAU - Pellegrino, Pierluigi
AU  - Pellegrino P
AUID- ORCID: 0000-0003-2961-2783
AD  - Cardiology Unit, University Polyclinic Hospital of Foggia, Foggia, Italy.
FAU - Goffredo, Giovanni
AU  - Goffredo G
AD  - Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
FAU - Pugliese, Rosanna
AU  - Pugliese R
AD  - Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
FAU - Correale, Michele
AU  - Correale M
AD  - Cardiology Unit, University Polyclinic Hospital of Foggia, Foggia, Italy.
FAU - Ieva, Riccardo
AU  - Ieva R
AD  - Cardiology Unit, University Polyclinic Hospital of Foggia, Foggia, Italy.
FAU - Di Biase, Matteo
AU  - Di Biase M
AD  - Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
FAU - Brunetti, Natale Daniele
AU  - Brunetti ND
AD  - Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
AD  - Cardiology Unit, University Polyclinic Hospital of Foggia, Foggia, Italy.
FAU - Iacoviello, Massimo
AU  - Iacoviello M
AUID- ORCID: 0000-0001-9613-5062
AD  - Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
AD  - Cardiology Unit, University Polyclinic Hospital of Foggia, Foggia, Italy.
LA  - eng
PT  - Journal Article
DEP - 20230812
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - Humans
MH  - Heart Rate
MH  - *Atrial Fibrillation
MH  - *Ventricular Dysfunction, Left
MH  - Heart Atria
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - atrioventricular function
OT  - pacing
OT  - two dimensional strain
EDAT- 2023/08/13 00:43
MHDA- 2023/09/08 06:42
CRDT- 2023/08/12 21:23
PHST- 2023/07/05 00:00 [revised]
PHST- 2023/04/23 00:00 [received]
PHST- 2023/08/01 00:00 [accepted]
PHST- 2023/09/08 06:42 [medline]
PHST- 2023/08/13 00:43 [pubmed]
PHST- 2023/08/12 21:23 [entrez]
AID - 10.1111/pace.14800 [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2023 Sep;46(9):1116-1123. doi: 10.1111/pace.14800. 
      Epub 2023 Aug 12.