PMID- 37573470
OWN - NLM
STAT- MEDLINE
DCOM- 20230816
LR  - 20231123
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Aug 12
TI  - Prognostic value of monocyte-to-lymphocyte ratio for 90-day all-cause mortality 
      in type 2 diabetes mellitus patients with chronic kidney disease.
PG  - 13136
LID - 10.1038/s41598-023-40429-6 [doi]
LID - 13136
AB  - The role of inflammation and the correlation between inflammatory markers and 
      type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) have been 
      studied. In clinical work, a large number of T2DM patients complicated with CKD, 
      but the cause of CKD was not clear. Our study aimed to evaluate the relationship 
      between monocyte-to-lymphocyte ratio (MLR) and mortality in T2DM patients with 
      CKD. The data from Medical Information Mart for Intensive Care III was analyzed. 
      The primary outcome was 90-day all-cause mortality; the secondary outcomes were 
      the length of ICU stay, hospital mortality and 30-day all-cause mortality. Cox 
      regression was used to evaluate the association between MLR and 90-day mortality. 
      We performed subgroup analyses to determine the consistency of this association, 
      and used Kaplan-Meier survival curve to analysis the survival of different levels 
      of MLR. A total of 1830 patients were included in study retrospectively. The 
      length of ICU stay, 30-day all-cause mortality, and 90-day all-cause mortality in 
      the MLR > 0.71 group were significantly higher than those in the MLR < 0.28 and 
      0.28 </= MLR </= 0.71 group. In Cox regression analysis, high MLR level was 
      significantly associated with increased greater risk of 90-day all-cause 
      mortality. The adjusted HR (95%CIs) for the model 1, model 2, and model 3 were 
      2.429 (1.905-3.098), 2.070 (1.619-2.647), and 1.898 (1.478-2.437), respectively. 
      Subgroup analyses also showed the consistency of association between MLR and 
      90-day all-cause mortality. The Kaplan-Meier survival curve analysis revealed 
      that MLR > 0.71 had worst prognosis. In T2DM patients with CKD in the intensive 
      care unit, high MLR was significantly associated with increased risk 90-day 
      all-cause mortality.
CI  - (c) 2023. Springer Nature Limited.
FAU - Qiu, Chuangye
AU  - Qiu C
AD  - Department of Nephrology, Jiangmen Central Hospital, Affiliated Jiangmen Hospital 
      of Sun Yat-Sen University, Jiangmen, Guangdong, China.
FAU - Liu, Shizhen
AU  - Liu S
AD  - Department of Nephrology, Jiangmen Central Hospital, Affiliated Jiangmen Hospital 
      of Sun Yat-Sen University, Jiangmen, Guangdong, China. 1107309479@qq.com.
FAU - Li, Xingai
AU  - Li X
AD  - Department of Nephrology, Jiangmen Central Hospital, Affiliated Jiangmen Hospital 
      of Sun Yat-Sen University, Jiangmen, Guangdong, China.
FAU - Li, Wenxia
AU  - Li W
AD  - Department of Endocrinology, Jiangmen Central Hospital, Affiliated Jiangmen 
      Hospital of Sun Yat-Sen University, Jiangmen, Guangdong, China.
FAU - Hu, Guoqiang
AU  - Hu G
AD  - Department of Nephrology, Jiangmen Central Hospital, Affiliated Jiangmen Hospital 
      of Sun Yat-Sen University, Jiangmen, Guangdong, China. tonyhu1001@163.com.
FAU - Liu, Fanna
AU  - Liu F
AD  - Department of Nephrology, The First Affiliated Hospital of Jinan University, 
      Guangzhou, 510630, Guangdong, China. tliufana@jnu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230812
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Humans
MH  - Monocytes
MH  - Prognosis
MH  - Retrospective Studies
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Lymphocytes
MH  - *Renal Insufficiency, Chronic/complications
PMC - PMC10423199
COIS- The authors declare no competing interests.
EDAT- 2023/08/13 00:43
MHDA- 2023/08/16 06:43
PMCR- 2023/08/12
CRDT- 2023/08/12 23:30
PHST- 2023/03/31 00:00 [received]
PHST- 2023/08/10 00:00 [accepted]
PHST- 2023/08/16 06:43 [medline]
PHST- 2023/08/13 00:43 [pubmed]
PHST- 2023/08/12 23:30 [entrez]
PHST- 2023/08/12 00:00 [pmc-release]
AID - 10.1038/s41598-023-40429-6 [pii]
AID - 40429 [pii]
AID - 10.1038/s41598-023-40429-6 [doi]
PST - epublish
SO  - Sci Rep. 2023 Aug 12;13(1):13136. doi: 10.1038/s41598-023-40429-6.