PMID- 37573805
OWN - NLM
STAT- MEDLINE
DCOM- 20230825
LR  - 20230825
IS  - 1873-4111 (Electronic)
IS  - 0378-5122 (Linking)
VI  - 176
DP  - 2023 Oct
TI  - Intrinsic capacity and risk of death: Focus on the impact of using different 
      diagnostic criteria for the nutritional domain.
PG  - 107817
LID - S0378-5122(23)00423-1 [pii]
LID - 10.1016/j.maturitas.2023.107817 [doi]
AB  - OBJECTIVE: We aimed to estimate the ability of intrinsic capacity (IC) to predict 
      death in community-dwelling older people using different diagnostic criteria to 
      define the nutritional domain. METHODS: Participants from the Belgian SarcoPhAge 
      cohort were followed from 2013 to the present. Four IC domains were assessed at 
      baseline (data on the sensorial domain were not collected), and considered 
      unsatisfactory below some specific thresholds. The nutritional domain was 
      considered unsatisfactory if baseline malnutrition was present, defined by: 1) 
      MNA-SF </=11 points; 2) seven versions of the GLIM criteria, varying by the 
      technique used to identify a reduced muscle mass; or 3) the combination of MNA-SF 
      </=11 points + GLIM criteria. The association between baseline unsatisfactory IC 
      and 9-year mortality was calculated using the odds ratio (OR) adjusted for 
      cofounders. RESULTS: Among the 534 participants (73.5 +/- 6.2 years old; 60.3 % 
      women at baseline), 157 (29.4 %) were dead after 9.3 +/- 0.3 years of follow-up. 
      Patients with baseline unsatisfactory IC in the locomotor domain (adjusted 
      OR = 2.31 [95%CI 1.38-3.86]) or psychological domain (adjusted OR = 1.78 
      [1.12-2.83]) were at higher mortality risk. Regarding malnutrition, 
      unsatisfactory IC in the nutrition domain was strongly associated with a higher 
      mortality risk, whatever the criteria used to identify a reduced muscle mass. The 
      highest association with mortality was found in participants with a baseline 
      unsatisfactory nutritional domain defined by the combination of MNA-SF + GLIM 
      criteria (adjusted OR = 3.27 [95%CI 1.72-6.23]). CONCLUSIONS: Presenting any 
      unsatisfactory IC at baseline was associated with a higher 9-year mortality risk 
      in community-dwelling older people. The sequential incorporation of MNA-SF and 
      GLIM criteria as the IC nutritional domain would be helpful to guide public 
      health actions towards healthy ageing.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Sanchez-Rodriguez, D
AU  - Sanchez-Rodriguez D
AD  - WHO Collaborating Centre for Public Health Aspects of Musculo-Skeletal Health and 
      Ageing, Division of Public Health, Epidemiology and Health Economics, University 
      of Liege, Liege, Belgium; Geriatrics Department, Brugmann University Hospital, 
      Universite Libre de Bruxelles, Brussels, Belgium; Geriatrics Department, Parc 
      Salut Mar, Rehabilitation Research Group, Hospital Del Mar Medical Research 
      Institute (IMIM), Barcelona, Spain. Electronic address: 
      dolores.sanchez@uliege.be.
FAU - Demonceau, C
AU  - Demonceau C
AD  - WHO Collaborating Centre for Public Health Aspects of Musculo-Skeletal Health and 
      Ageing, Division of Public Health, Epidemiology and Health Economics, University 
      of Liege, Liege, Belgium.
FAU - Bruyere, O
AU  - Bruyere O
AD  - WHO Collaborating Centre for Public Health Aspects of Musculo-Skeletal Health and 
      Ageing, Division of Public Health, Epidemiology and Health Economics, University 
      of Liege, Liege, Belgium.
FAU - Cavalier, E
AU  - Cavalier E
AD  - Department of Clinical Chemistry, University of Liege, CHU - Sart Tilman, Liege, 
      Belgium.
FAU - Reginster, J-Y
AU  - Reginster JY
AD  - WHO Collaborating Centre for Public Health Aspects of Musculo-Skeletal Health and 
      Ageing, Division of Public Health, Epidemiology and Health Economics, University 
      of Liege, Liege, Belgium.
FAU - Beaudart, C
AU  - Beaudart C
AD  - WHO Collaborating Centre for Public Health Aspects of Musculo-Skeletal Health and 
      Ageing, Division of Public Health, Epidemiology and Health Economics, University 
      of Liege, Liege, Belgium; Department of Health Services Research, University of 
      Maastricht, Maastricht, the Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20230803
PL  - Ireland
TA  - Maturitas
JT  - Maturitas
JID - 7807333
SB  - IM
MH  - Humans
MH  - Female
MH  - Aged
MH  - Male
MH  - *Malnutrition/diagnosis
MH  - Nutritional Status
MH  - Independent Living
MH  - Geriatric Assessment/methods
MH  - Nutrition Assessment
OTO - NOTNLM
OT  - GLIM criteria
OT  - GLIS on sarcopenia
OT  - Intrinsic capacity
OT  - Malnutrition in adults
OT  - SarcoPhAge
COIS- Declaration of competing interest DS-R, OB, Y-IR, and CB serve as Senior Advisors 
      to the World Health Organization (WHO) Collaborating Center for Epidemiology of 
      Musculoskeletal Health and Ageing, Division of Public Health, Epidemiology, and 
      Health Economics, University of Liege, Liege, Belgium. Y-IR serves as a member of 
      the Board of Directors of the Clinical Consortium on Healthy Ageing (CCHA) of the 
      WHO, Geneve, Switzerland. DS-R and OB serve as Editorial Board members of 
      Maturitas. All authors declare they do not have any personal or financial 
      relationships with other organizations or people that could inappropriately 
      influence their work.
EDAT- 2023/08/14 00:42
MHDA- 2023/08/25 06:42
CRDT- 2023/08/13 18:39
PHST- 2023/03/24 00:00 [received]
PHST- 2023/07/04 00:00 [revised]
PHST- 2023/07/27 00:00 [accepted]
PHST- 2023/08/25 06:42 [medline]
PHST- 2023/08/14 00:42 [pubmed]
PHST- 2023/08/13 18:39 [entrez]
AID - S0378-5122(23)00423-1 [pii]
AID - 10.1016/j.maturitas.2023.107817 [doi]
PST - ppublish
SO  - Maturitas. 2023 Oct;176:107817. doi: 10.1016/j.maturitas.2023.107817. Epub 2023 
      Aug 3.