PMID- 37574869
OWN - NLM
STAT- Publisher
LR  - 20231221
IS  - 1942-7522 (Electronic)
IS  - 0145-5613 (Linking)
DP  - 2023 Aug 13
TI  - Early Death Incidence and Prediction Among Patients With Hypopharynx Squamous 
      Cell Carcinomas.
PG  - 1455613231192282
LID - 10.1177/01455613231192282 [doi]
AB  - Background: The objective of this study is to evaluate the incidence and 
      associated factors for early death (ED) in hypopharynx squamous cell carcinomas 
      (SCC) patients. Materials and Methods: Patients were extracted from the 
      Surveillance, Epidemiology and End Results database between 2004 and 2014. The ED 
      (survival time </=3 months) rate was calculated, and associated risk factors were 
      evaluated by the logistic regression models. Results: A total of 2659 patients 
      were analyzed and 307 (11.5%) patients died within 3 months after cancer 
      diagnosis, among whom 243 (79.2%) patients died from cancer-specific cause. In 
      univariate analyses, advanced age, divorced/single/widowed (DSW), non-Caucasian, 
      advanced T classification, distant metastasis, and no surgery were significantly 
      associated with ED (P < .05, respectively). Multivariate analyses showed that 
      advanced age, DSW, advanced T classification, distant metastasis, and no surgery 
      were significantly associated with all-cause and cancer-specific ED. Conclusion: 
      Our results showed that a total of 11.5% patients with hypopharynx SCC suffered 
      ED, among whom 79.2% patients died from cancer-specific cause. Predictors of ED 
      are primarily related to age >/=62 years, advanced T classification, distant 
      metastasis, and no surgery but also include unmarried status; better prognostic 
      and predictive tools for select ED patients in larger sample size are needed.
FAU - Li, Yujiao
AU  - Li Y
AD  - Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan 
      University Cancer Hospital, Shanghai, China.
AD  - Shanghai Key Laboratory of Radiation Oncology, Shanghai, China.
AD  - Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, 
      Shanghai, China.
AD  - Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 
      Shanghai, China.
AD  - Department of Oncology, Shanghai Medical College, Shanghai, China.
FAU - Hu, Chaosu
AU  - Hu C
AUID- ORCID: 0000-0002-0811-8180
AD  - Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan 
      University Cancer Hospital, Shanghai, China.
AD  - Shanghai Key Laboratory of Radiation Oncology, Shanghai, China.
AD  - Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, 
      Shanghai, China.
AD  - Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 
      Shanghai, China.
AD  - Department of Oncology, Shanghai Medical College, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20230813
PL  - United States
TA  - Ear Nose Throat J
JT  - Ear, nose, & throat journal
JID - 7701817
SB  - IM
OTO - NOTNLM
OT  - early death
OT  - hypopharynx squamous cell carcinomas
OT  - incidence
OT  - risk factors
COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2023/08/14 06:42
MHDA- 2023/08/14 06:42
CRDT- 2023/08/14 02:33
PHST- 2023/08/14 06:42 [pubmed]
PHST- 2023/08/14 06:42 [medline]
PHST- 2023/08/14 02:33 [entrez]
AID - 10.1177/01455613231192282 [doi]
PST - aheadofprint
SO  - Ear Nose Throat J. 2023 Aug 13:1455613231192282. doi: 10.1177/01455613231192282.