PMID- 37575093
OWN - NLM
STAT- MEDLINE
DCOM- 20230816
LR  - 20230817
IS  - 2296-2565 (Electronic)
IS  - 2296-2565 (Linking)
VI  - 11
DP  - 2023
TI  - Sex-specific associations between nine metal mixtures in urine and urine flow 
      rate in US adults: NHANES 2009-2018.
PG  - 1241971
LID - 10.3389/fpubh.2023.1241971 [doi]
LID - 1241971
AB  - BACKGROUND: The urinary system serves as a crucial pathway for eliminating 
      metallic substances from the body, making it susceptible to the effects of metal 
      exposure. However, limited research has explored the association between metal 
      mixtures and bladder function. This study aims to investigate the relationship 
      between urinary metal mixtures (specifically barium, cadmium, cobalt, cesium, 
      molybdenum, lead, antimony, thallium, and tungsten) and urine flow rate (UFR) in 
      the general population, utilizing multiple mixture analysis models. METHODS: This 
      study utilizes data obtained from the National Health and Nutrition Examination 
      Survey. After adjusting for relevant covariates, we assessed the correlations 
      between metal mixtures and UFR using three distinct analysis models: weighted 
      quantile sum (WQS), quantile g-computation (qgcomp), and Bayesian kernel machine 
      regression (BKMR). Additionally, a gender-stratified analysis was conducted. 
      Finally, we also performed sensitivity analyses. RESULTS: A total of 7,733 
      subjects were included in this study, with 49% being male. The WQS regression 
      model, when fitted in the positive direction, did not yield any significant 
      correlations in the overall population or in the male and female subgroups. 
      However, when analyzed in the negative direction, the WQS index exhibited a 
      negative correlation with UFR in the overall group (beta = -0.078; 95% CI: -0.111, 
      -0.045). Additionally, a significant negative correlation between the WQS index 
      and UFR was observed in the female group (beta = -0.108; 95% CI: -0.158, -0.059), 
      while no significant correlation was found in the male group. The results 
      obtained from the qgcomp regression model were consistent with those of the WQS 
      regression model. Similarly, the BKMR regression model revealed a significant 
      negative correlation trend between metal mixtures and UFR, with cadmium and 
      antimony potentially playing key roles. CONCLUSION: Our study revealed a 
      significant negative correlation between urinary metal mixture exposure and mean 
      UFR in US adults, with notable gender differences. Specifically, higher urinary 
      levels of cadmium and antimony were identified as potential key factors 
      contributing to the decrease in mean UFR. These findings significantly contribute 
      to the existing knowledge on the impact of metal mixtures on bladder function and 
      provide valuable insights for safeguarding bladder health and preventing impaired 
      bladder function.
CI  - Copyright (c) 2023 Zhang, Tang and Zhou.
FAU - Zhang, Shuai
AU  - Zhang S
AD  - Department of Male Reproductive Health, Lianyungang Maternal and Child Health 
      Hospital, Lianyungang, China.
AD  - Clinical Center of Reproductive Medicine, Lianyungang Maternal and Child Health 
      Hospital, Lianyungang, China.
FAU - Tang, Hanhan
AU  - Tang H
AD  - Graduate School of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, 
      China.
FAU - Zhou, Minglian
AU  - Zhou M
AD  - Department of Male Reproductive Health, Lianyungang Maternal and Child Health 
      Hospital, Lianyungang, China.
AD  - Clinical Center of Reproductive Medicine, Lianyungang Maternal and Child Health 
      Hospital, Lianyungang, China.
LA  - eng
PT  - Journal Article
DEP - 20230728
PL  - Switzerland
TA  - Front Public Health
JT  - Frontiers in public health
JID - 101616579
RN  - 00BH33GNGH (Cadmium)
RN  - 9IT35J3UV3 (Antimony)
SB  - IM
MH  - Humans
MH  - Male
MH  - Adult
MH  - Female
MH  - *Environmental Exposure
MH  - *Cadmium
MH  - Nutrition Surveys
MH  - Antimony/analysis
MH  - Bayes Theorem
PMC - PMC10420057
OTO - NOTNLM
OT  - BKMR
OT  - NHANES
OT  - US adults
OT  - WQS
OT  - metal mixtures
OT  - qgcomp
OT  - urine flow rate
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/08/14 06:42
MHDA- 2023/08/16 06:42
PMCR- 2023/07/28
CRDT- 2023/08/14 04:24
PHST- 2023/06/18 00:00 [received]
PHST- 2023/07/19 00:00 [accepted]
PHST- 2023/08/16 06:42 [medline]
PHST- 2023/08/14 06:42 [pubmed]
PHST- 2023/08/14 04:24 [entrez]
PHST- 2023/07/28 00:00 [pmc-release]
AID - 10.3389/fpubh.2023.1241971 [doi]
PST - epublish
SO  - Front Public Health. 2023 Jul 28;11:1241971. doi: 10.3389/fpubh.2023.1241971. 
      eCollection 2023.