PMID- 37575991
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230815
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 10
DP  - 2023
TI  - Association between FGA gene polymorphisms and coronary artery lesion in Kawasaki 
      disease.
PG  - 1193303
LID - 10.3389/fmed.2023.1193303 [doi]
LID - 1193303
AB  - OBJECTIVE: To investigate the correlation between FGA gene polymorphisms and 
      coronary artery lesion in Kawasaki disease. METHODS: Two hundred and thirty four 
      children with Kawasaki disease (KD group), 200 healthy children (normal group) 
      and 208 children with non-KD fever (fever group) were enrolled. General clinical 
      indicators, the concentration of serum MMPs, TIMP-1, FG-alpha,fibrinogen level, 
      molecular function (FMPV/ODmax) and FGA Thr312Ala polymorphism were detected 
      individually by testing peripheral venous blood after fasting in the morning. 
      RESULTS: There was no significant difference in average age among the three 
      groups, which were 3.03 +/- 1.22 years, 3.17 +/- 1.30 years, and 3.21 +/- 1.31 years, 
      respectively. Compared with those in the fever group, the levels of white blood 
      cell count (WBC), platelet count (PLT), procalcitonin (PCT), C-reactive protein 
      (CRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), monocyte 
      chemoattractant protein-1 (MCP-1), and fibrinogen (Fg) levels were significantly 
      increased in the KD group. Red blood cell count (RBC) and hemoglobin (Hb) levels 
      were significantly decreased (p < 0.05).The concentration of serum MMPs, TIMP-1, 
      and FG-alpha in the KD and fever groups were significantly higher than those in the 
      normal group (p < 0.05). The concentration of MMP-2, MMP-3, MMP-9, MMP-13, 
      TIMP-1, and FG-alpha in the KD group were significantly higher than those in the 
      fever group (p < 0.05).The KD group was divided into two subgroups,55 patients 
      with combined CAL and 179 patients without combined CAL. The plasma fibrinogen 
      concentration in the combined CAL group was significantly higher than that in the 
      non-combined CAL and normal groups (p < 0.01). There was no statistically 
      significant difference in FMPV/ODmax among the three groups (p > 0.05). Compared 
      with normal group, the FGA GG, GA, and AA genotype and G, A allele frequency of 
      the FGA gene polymorphism in the KD group showed no significant difference 
      (p > 0.05). In the KD group, the most common type in children with CAL was GA, 
      while the most common type in children without CAL was GG. CONCLUSION: MMPs and 
      FG-alpha were significantly upregulated in KD patients. The proportion of FGA 
      genotype GA in children with CAL was significantly higher than that in children 
      without CAL, suggesting that FGA gene polymorphisms affect coronary artery lesion 
      in children with KD.
CI  - Copyright (c) 2023 Liu, Chen, Yang, Su, Wang, Zhanghuang, Wu and Zhang.
FAU - Liu, Xingzhu
AU  - Liu X
AD  - Department of Special Needs Ward, Kunming Children's Hospital, Kunming, Yunnan, 
      China.
FAU - Chen, Yanfei
AU  - Chen Y
AD  - Department of Cardiology, Kunming Children's Hospital, Kunming, Yunnan, China.
FAU - Yang, Yanfei
AU  - Yang Y
AD  - Department of Special Needs Ward, Kunming Children's Hospital, Kunming, Yunnan, 
      China.
FAU - Su, Zhongjian
AU  - Su Z
AD  - Department of Cardiology, Kunming Children's Hospital, Kunming, Yunnan, China.
FAU - Wang, Feng
AU  - Wang F
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, 
      Yunnan, China.
FAU - Zhanghuang, Chenghao
AU  - Zhanghuang C
AD  - Department of Urology, Yunnan Key Laboratory of Children's Major Disease 
      Research, Kunming Children's Hospital, Yunnan Province Clinical Research Center 
      for Children's Health and Disease, Kunming, Yunnan, China.
FAU - Wu, Yuqin
AU  - Wu Y
AD  - Department of Special Needs Ward, Kunming Children's Hospital, Kunming, Yunnan, 
      China.
FAU - Zhang, Xing
AU  - Zhang X
AD  - Department of Cardiology, Kunming Children's Hospital, Kunming, Yunnan, China.
LA  - eng
PT  - Journal Article
DEP - 20230727
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC10413112
OTO - NOTNLM
OT  - FGA gene
OT  - Kawasaki disease
OT  - MMP
OT  - coronary artery lesion
OT  - polymorphism
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/08/14 06:42
MHDA- 2023/08/14 06:43
PMCR- 2023/07/27
CRDT- 2023/08/14 04:37
PHST- 2023/03/24 00:00 [received]
PHST- 2023/07/10 00:00 [accepted]
PHST- 2023/08/14 06:43 [medline]
PHST- 2023/08/14 06:42 [pubmed]
PHST- 2023/08/14 04:37 [entrez]
PHST- 2023/07/27 00:00 [pmc-release]
AID - 10.3389/fmed.2023.1193303 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2023 Jul 27;10:1193303. doi: 10.3389/fmed.2023.1193303. 
      eCollection 2023.