PMID- 37576106
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230815
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 10
DP  - 2023
TI  - External validation of the REMEMBER score.
PG  - 1192300
LID - 10.3389/fcvm.2023.1192300 [doi]
LID - 1192300
AB  - BACKGROUND: The use of venoarterial extracorporeal membrane oxygenation (VA-ECMO) 
      after coronary artery bypass grafting (CABG) is associated with high in-hospital 
      mortality rates. The pRedicting mortality in patients undergoing venoarterial 
      Extracorporeal MEMBrane oxygenation after coronary artEry bypass gRafting 
      (REMEMBER) score has been created to predict in-hospital mortality in this 
      subgroup of patients. The aim of this study is to externally validate the 
      REMEMBER score. METHODS: All CABG patients who received VA-ECMO during or after 
      the operation at our center between 01/2012 and 12/2021 were included in the 
      analysis. Discrimination was assessed using concordance statistics, visualized by 
      ROC curve analysis. Calibration-in-the-large and Calibration slope were tested 
      separately. RESULTS: A total of 107 patients (male: n = 78, 72.9%) were included 
      in this study. The in-hospital mortality rate in our cohort was 45.8% compared 
      with 55% in the original study. The REMEMBER score median predicted mortality 
      rate was 52% (76.9-36%). However, the REMEMBER score showed low discriminative 
      ability [AUC: 0.623 (p = 0.0244; 95% CI = 0.524-0.715)] and inaccurate 
      calibration (intercept = 0.25074; p = 0.0195; slope = 0.39504; p = 0.0303), 
      indicating poor performance. CONCLUSIONS: The REMEMBER score did not predict 
      in-hospital mortality and was therefore not applicable in our cohort of patients. 
      Additional external validation studies in a multicenter setting are therefore 
      advisable.
CI  - (c) 2023 Peivandi, Welp, Kintrup, Wagner and Dell'aquila.
FAU - Peivandi, Armin Darius
AU  - Peivandi AD
AD  - Department of Cardiothoracic Surgery, University Hospital Muenster, Muenster, 
      Germany.
FAU - Welp, Henryk
AU  - Welp H
AD  - Department of Cardiothoracic Surgery, University Hospital Muenster, Muenster, 
      Germany.
FAU - Kintrup, Sebastian
AU  - Kintrup S
AD  - Department of Anesthesiology, Intensive Care and Pain Therapy, University 
      Hospital Muenster, Muenster, Germany.
FAU - Wagner, Nana Maria
AU  - Wagner NM
AD  - Department of Anesthesiology, Intensive Care and Pain Therapy, University 
      Hospital Muenster, Muenster, Germany.
FAU - Dell'Aquila, Angelo Maria
AU  - Dell'Aquila AM
AD  - Department of Cardiothoracic Surgery, University Hospital Muenster, Muenster, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20230728
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC10416794
OTO - NOTNLM
OT  - cardiac failure
OT  - coronary artery bypass grafting
OT  - extracorporeal life support
OT  - risk score
OT  - score system
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/08/14 06:42
MHDA- 2023/08/14 06:43
PMCR- 2023/01/01
CRDT- 2023/08/14 04:38
PHST- 2023/03/23 00:00 [received]
PHST- 2023/07/17 00:00 [accepted]
PHST- 2023/08/14 06:43 [medline]
PHST- 2023/08/14 06:42 [pubmed]
PHST- 2023/08/14 04:38 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2023.1192300 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2023 Jul 28;10:1192300. doi: 10.3389/fcvm.2023.1192300. 
      eCollection 2023.