PMID- 37576664
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230815
IS  - 2470-1343 (Electronic)
IS  - 2470-1343 (Linking)
VI  - 8
IP  - 31
DP  - 2023 Aug 8
TI  - Biocompatible Drug Delivery System Based on a MOF Platform for a Sustained and 
      Controlled Release of the Poorly Soluble Drug Norfloxacin.
PG  - 28367-28375
LID - 10.1021/acsomega.3c02418 [doi]
AB  - Norfloxacin (NFX), an important antibacterial fluoroquinolone, is a class IV drug 
      according to the biopharmaceutics classification system (BCS) and has low 
      solubility and permeability issues. Such poor physicochemical properties of drug 
      molecules lead to poor delivery and are of serious concern to the pharmaceutical 
      industry for clinical development. We present here a conceptually new approach to 
      deliver NFX, by loading the drug molecule on the porous platform of a 
      biocompatible metal-organic framework (MOF), MIL-100(Fe). The loading of the drug 
      on the MOF leading to NFX@MIL-100(Fe) was characterized by Fourier transform 
      infrared (FTIR), UV-visible spectroscopy, thermogravimetric analyses (TGA), and 
      nitrogen adsorption studies. Controlled experiments resulted in the high loading 
      of the drug molecule ( approximately 20 wt %) along with the desired sustained release. We 
      could further control the release of norfloxacin by coating drug-loaded 
      MIL-100(Fe) with PEG, PEGNFX@MIL-100(Fe). Both drug delivery systems (DDSs), 
      NFX@MIL-100(Fe) and PEGNFX@MIL-100(Fe), were tested for their biocompatibility 
      through toxicity studies. The DDSs are biocompatible and show insignificant 
      cytotoxicity, as revealed by cell viability studies through the 
      3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.
CI  - (c) 2023 The Authors. Published by American Chemical Society.
FAU - Yadav, Preety
AU  - Yadav P
AD  - Department of Chemistry, School of Basic Sciences, Central University of Haryana, 
      Jant-Pali, Mahendergarh 123031, Haryana, India.
FAU - Kumari, Sarita
AU  - Kumari S
AD  - Department of Chemistry, School of Basic Sciences, Central University of Haryana, 
      Jant-Pali, Mahendergarh 123031, Haryana, India.
FAU - Yadav, Anand
AU  - Yadav A
AD  - Department of Chemistry, School of Basic Sciences, Central University of Haryana, 
      Jant-Pali, Mahendergarh 123031, Haryana, India.
FAU - Bhardwaj, Priya
AU  - Bhardwaj P
AD  - Department of Biochemistry, School of Interdisciplinary and Applied Sciences, 
      Central University of Haryana, Jant-Pali, Mahendergarh 123031, Haryana, India.
FAU - Maruthi, Mulaka
AU  - Maruthi M
AD  - Department of Biochemistry, School of Interdisciplinary and Applied Sciences, 
      Central University of Haryana, Jant-Pali, Mahendergarh 123031, Haryana, India.
FAU - Chakraborty, Anindita
AU  - Chakraborty A
AUID- ORCID: 0000-0001-5109-3890
AD  - Department of Chemistry, School of Basic Sciences, Central University of Haryana, 
      Jant-Pali, Mahendergarh 123031, Haryana, India.
FAU - Kanoo, Prakash
AU  - Kanoo P
AUID- ORCID: 0009-0009-0798-7964
AD  - Department of Chemistry, School of Basic Sciences, Central University of Haryana, 
      Jant-Pali, Mahendergarh 123031, Haryana, India.
LA  - eng
PT  - Journal Article
DEP - 20230727
PL  - United States
TA  - ACS Omega
JT  - ACS omega
JID - 101691658
PMC - PMC10413448
COIS- The authors declare no competing financial interest.
EDAT- 2023/08/14 06:42
MHDA- 2023/08/14 06:43
PMCR- 2023/07/27
CRDT- 2023/08/14 04:46
PHST- 2023/04/10 00:00 [received]
PHST- 2023/07/14 00:00 [accepted]
PHST- 2023/08/14 06:43 [medline]
PHST- 2023/08/14 06:42 [pubmed]
PHST- 2023/08/14 04:46 [entrez]
PHST- 2023/07/27 00:00 [pmc-release]
AID - 10.1021/acsomega.3c02418 [doi]
PST - epublish
SO  - ACS Omega. 2023 Jul 27;8(31):28367-28375. doi: 10.1021/acsomega.3c02418. 
      eCollection 2023 Aug 8.