PMID- 37576729
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230815
IS  - 1677-7301 (Electronic)
IS  - 1677-5449 (Print)
IS  - 1677-5449 (Linking)
VI  - 22
DP  - 2023
TI  - Influence of atherosclerosis risk factors on the anatomical distribution of 
      peripheral arterial disease in patients with chronic limb-threatening ischemia: a 
      cross-sectional study.
PG  - e20230014
LID - 10.1590/1677-5449.202300141 [doi]
LID - e20230014
AB  - BACKGROUND: Atherosclerosis risk factors can have different impacts on 
      cardiovascular diseases and on the anatomical distribution of Peripheral Arterial 
      Disease (PAD). OBJECTIVES: To study the influence of atherosclerosis risk factors 
      on the anatomical distribution of PAD in patients with chronic limb-threatening 
      ischemia (CLTI). METHODS: We performed an observational, cross-sectional, and 
      analytical study that included 476 hospitalized patients with CLTI due to PAD. We 
      compared the presence of atherosclerosis risk factors (age, gender, diabetes 
      mellitus, smoking, and hypertension) in patients with PAD involving three 
      different anatomic areas (aortoiliac, femoropopliteal, and infrapopliteal). 
      Multivariate analysis was performed to identify associations between 
      atherosclerosis risk factors and PAD distribution. RESULTS: The mean age of the 
      476 patients was 69 years, 249 (52%) were men, and 273 (57%) had diabetes. 
      Seventy-four percent (353) had minor tissue loss. Multivariate analysis 
      identified three risk factors associated with PAD anatomical distribution 
      (gender, smoking, and DM). Women had a 2.7 (CI: 1.75-4.26) times greater chance 
      of having femoropopliteal disease. Smokers had a 3.6-fold (CI: 1.54-8.30) greater 
      risk of aortoiliac disease. Diabetic patients were 1.8 (CI: 1.04-3.19) times more 
      likely to have isolated infrapopliteal occlusive disease. CONCLUSIONS: The study 
      showed that gender, DM, and smoking impact on the anatomical distribution of PAD 
      in patients with CLTI. Diabetic patients were more likely to have only 
      infrapopliteal disease, women had a greater risk of femoropopliteal PAD, and 
      smokers had a greater risk of aortoiliac occlusive disease.
CI  - Copyright(c) 2023 The authors.
FAU - Dos Santos, Vanessa Prado
AU  - Dos Santos VP
AUID- ORCID: 0000-0003-2754-8618
AD  - Universidade Federal da Bahia - UFBA, Hospital Universitario Professor Edgard 
      Santos - HUPES, Salvador, BA, Brasil.
FAU - Cerutti, Camila Izabel
AU  - Cerutti CI
AD  - Universidade Federal da Bahia - UFBA, Hospital Universitario Professor Edgard 
      Santos - HUPES, Salvador, BA, Brasil.
FAU - Alencar, Marcelo Jose Carlos
AU  - Alencar MJC
AD  - Universidade Federal da Bahia - UFBA, Hospital Universitario Professor Edgard 
      Santos - HUPES, Salvador, BA, Brasil.
FAU - Queiroz, Andre Brito
AU  - Queiroz AB
AD  - Universidade Federal da Bahia - UFBA, Hospital Universitario Professor Edgard 
      Santos - HUPES, Salvador, BA, Brasil.
FAU - Ferreira, Lucas de Mello
AU  - Ferreira LM
AD  - Universidade Federal da Bahia - UFBA, Hospital Universitario Professor Edgard 
      Santos - HUPES, Salvador, BA, Brasil.
FAU - Fidelis, Cicero
AU  - Fidelis C
AD  - Universidade Federal da Bahia - UFBA, Hospital Universitario Professor Edgard 
      Santos - HUPES, Salvador, BA, Brasil.
FAU - de Araujo, Jose Siqueira
AU  - de Araujo JS
AD  - Universidade Federal da Bahia - UFBA, Hospital Universitario Professor Edgard 
      Santos - HUPES, Salvador, BA, Brasil.
FAU - Alves, Carlos Alberto Silveira
AU  - Alves CAS
AD  - Universidade Federal da Bahia - UFBA, Hospital Universitario Professor Edgard 
      Santos - HUPES, Salvador, BA, Brasil.
LA  - eng
PT  - Journal Article
DEP - 20230717
PL  - Brazil
TA  - J Vasc Bras
JT  - Jornal vascular brasileiro
JID - 101262256
PMC - PMC10421571
OTO - NOTNLM
OT  - atherosclerosis
OT  - chronic limb-threatening ischemia
OT  - diabetes mellitus
OT  - peripheral arterial disease
OT  - risk factors
COIS- Conflicts of interest: No conflicts of interest declared concerning the 
      publication of this article.
EDAT- 2023/08/14 06:42
MHDA- 2023/08/14 06:43
PMCR- 2023/07/17
CRDT- 2023/08/14 04:46
PHST- 2023/01/20 00:00 [received]
PHST- 2023/04/18 00:00 [accepted]
PHST- 2023/08/14 06:43 [medline]
PHST- 2023/08/14 06:42 [pubmed]
PHST- 2023/08/14 04:46 [entrez]
PHST- 2023/07/17 00:00 [pmc-release]
AID - jvbAO20230014 [pii]
AID - 10.1590/1677-5449.202300141 [doi]
PST - epublish
SO  - J Vasc Bras. 2023 Jul 17;22:e20230014. doi: 10.1590/1677-5449.202300141. 
      eCollection 2023.