PMID- 37576858
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230815
IS  - 1319-0164 (Print)
IS  - 2213-7475 (Electronic)
IS  - 1319-0164 (Linking)
VI  - 31
IP  - 8
DP  - 2023 Aug
TI  - A physiologically based pharmacokinetic model of cefepime to predict its 
      pharmacokinetics in healthy, pediatric and disease populations.
PG  - 101675
LID - 10.1016/j.jsps.2023.06.008 [doi]
LID - 101675
AB  - The physiologically based pharmacokinetic modeling (PBPK) approach can predict 
      drug pharmacokinetics (PK) by combining changes in blood flow and 
      pathophysiological alterations for developing drug-disease models. Cefepime 
      hydrochloride is a parenteral cephalosporin that is used to treat pneumonia, 
      sepsis, and febrile neutropenia, among other things. The current study sought to 
      identify the factors that impact cefepime pharmacokinetics (PK) following dosing 
      in healthy, diseased (CKD and obese), and pediatric populations. For model 
      construction and simulation, the modeling tool PK-SIM was utilized. Estimating 
      cefepime PK following intravenous (IV) application in healthy subjects served as 
      the primary step in the model-building procedure. The prediction of cefepime PK 
      in chronic kidney disease (CKD) and obese populations were performed after the 
      integration of the relevant pathophysiological changes. Visual predictive checks 
      and a comparison of the observed and predicted values of the PK parameters were 
      used to verify the developed model. The results of the PK parameters were 
      consistent with the reported clinical data in healthy subjects. The developed 
      PBPK model successfully predicted cefepime PK as observed from the ratio of the 
      observed and predicted PK parameters as they were within a two-fold error range.
CI  - (c) 2023 The Author(s).
FAU - Talha Zahid, Muhammad
AU  - Talha Zahid M
AD  - Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya 
      University, 60800, Multan, Pakistan.
FAU - Zamir, Ammara
AU  - Zamir A
AD  - Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya 
      University, 60800, Multan, Pakistan.
FAU - Majeed, Abdul
AU  - Majeed A
AD  - Department of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, 
      60800, Multan, Pakistan.
FAU - Imran, Imran
AU  - Imran I
AD  - Department of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, 
      60800, Multan, Pakistan.
FAU - Alsanea, Sary
AU  - Alsanea S
AD  - Department of Pharmacology and Toxicology, College of Pharmacy, King Saud 
      University, Riyadh 11451, Saudi Arabia.
FAU - Ahmad, Tanveer
AU  - Ahmad T
AD  - Institute for Advanced Biosciences (IAB), CNRS UMR5309, INSERM U1209, Grenoble 
      Alpes University, La Tronche 38700, France.
FAU - Alqahtani, Faleh
AU  - Alqahtani F
AD  - Department of Pharmacology and Toxicology, College of Pharmacy, King Saud 
      University, Riyadh 11451, Saudi Arabia.
FAU - Fawad Rasool, Muhammad
AU  - Fawad Rasool M
AD  - Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya 
      University, 60800, Multan, Pakistan.
LA  - eng
PT  - Journal Article
DEP - 20230619
PL  - Saudi Arabia
TA  - Saudi Pharm J
JT  - Saudi pharmaceutical journal : SPJ : the official publication of the Saudi 
      Pharmaceutical Society
JID - 9705695
PMC - PMC10415223
OTO - NOTNLM
OT  - Cefepime
OT  - Cephalosporin
OT  - Chronic kidney disease
OT  - Obese
OT  - PBPK
OT  - Pediatrics
OT  - Pharmacokinetics
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2023/08/14 06:42
MHDA- 2023/08/14 06:43
PMCR- 2023/06/19
CRDT- 2023/08/14 04:48
PHST- 2023/03/22 00:00 [received]
PHST- 2023/06/12 00:00 [accepted]
PHST- 2023/08/14 06:43 [medline]
PHST- 2023/08/14 06:42 [pubmed]
PHST- 2023/08/14 04:48 [entrez]
PHST- 2023/06/19 00:00 [pmc-release]
AID - S1319-0164(23)00160-3 [pii]
AID - 101675 [pii]
AID - 10.1016/j.jsps.2023.06.008 [doi]
PST - ppublish
SO  - Saudi Pharm J. 2023 Aug;31(8):101675. doi: 10.1016/j.jsps.2023.06.008. Epub 2023 
      Jun 19.