PMID- 37576903
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230815
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 13
DP  - 2023
TI  - Case Report: Analysis of four cases of metastatic bladder masses after radical 
      prostatectomy.
PG  - 1211027
LID - 10.3389/fonc.2023.1211027 [doi]
LID - 1211027
AB  - OBJECTIVE: The aim of this study is to investigate the clinical characteristics 
      and diagnostic and therapeutic methods of bladder metastasis after radical 
      prostatectomy and to improve its diagnosis and treatment. METHODS: The clinical 
      data of four patients with bladder metastasis after radical prostatectomy were 
      retrospectively analyzed from January 2011 to December 2021. Three cases suffered 
      from intermittent gross hematuria, and only one case was found to have an 
      elevated prostate-specific antigen (PSA) value. Transurethral resection of 
      bladder tumor was performed in four cases, in which one case also underwent 
      resection of urethral mass. Three cases received endocrine therapy, one of which 
      added intravesical instillation and radiation therapy. Another case received 
      chemotherapy based on comprehensive treatment. RESULTS: According to the 
      pathological and immunohistochemical results, three cases were acinar 
      adenocarcinoma of the prostate with Gleason score of 9, and all cases were PSA 
      positive and negative for cytokeratin 7 (CK7) and GATA binding protein 3 
      (GATA-3). One case was small cell neuroendocrine carcinoma of the prostate and 
      was positive for chromogranin A (CGA), synaptophysin (SYN), and cluster of 
      differentiation 56 (CD56). During the follow-up period of 4 to 13 months, one 
      case was lost to follow-up and three cases were alive. CONCLUSION: Bladder 
      metastasis after radical prostatectomy is rare, and pathology combined with 
      immunohistochemistry is the gold standard for its diagnosis. Pathological type 
      determines its treatment. Systemic treatment is essential, and local treatment is 
      the most palliative means. Early diagnosis and treatment is significant for 
      better prognosis.
CI  - Copyright (c) 2023 Wang, Xie, Lu, Chu, Wang, Qiao, Wu and Wang.
FAU - Wang, Hao
AU  - Wang H
AD  - Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, China.
FAU - Xie, Dawei
AU  - Xie D
AD  - Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, China.
FAU - Lu, Jun
AU  - Lu J
AD  - Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, China.
FAU - Chu, Yifan
AU  - Chu Y
AD  - Department of Urology, Beijing Daxing District People's Hospital, Beijiing, 
      China.
FAU - Wang, Siqi
AU  - Wang S
AD  - Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, China.
FAU - Qiao, Peng
AU  - Qiao P
AD  - Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, China.
FAU - Wu, Liyang
AU  - Wu L
AD  - Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, China.
FAU - Wang, Jianwen
AU  - Wang J
AD  - Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, China.
LA  - eng
PT  - Case Reports
DEP - 20230728
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC10417713
OTO - NOTNLM
OT  - bladder metastasis
OT  - diagnosis
OT  - prognosis
OT  - prostate cancer
OT  - radical prostatectomy
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/08/14 06:41
MHDA- 2023/08/14 06:42
PMCR- 2023/01/01
CRDT- 2023/08/14 04:49
PHST- 2023/04/24 00:00 [received]
PHST- 2023/07/05 00:00 [accepted]
PHST- 2023/08/14 06:42 [medline]
PHST- 2023/08/14 06:41 [pubmed]
PHST- 2023/08/14 04:49 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2023.1211027 [doi]
PST - epublish
SO  - Front Oncol. 2023 Jul 28;13:1211027. doi: 10.3389/fonc.2023.1211027. eCollection 
      2023.