PMID- 37577041
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230815
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 16
DP  - 2023
TI  - Non-Traditional Blood Lipid Indices for Metabolism Dysfunction-Associated Fatty 
      Liver Disease Prediction in Non-Obese Type 2 Diabetes Mellitus.
PG  - 2345-2354
LID - 10.2147/DMSO.S418020 [doi]
AB  - OBJECTIVE: This study aims to investigate the predictive value of non-traditional 
      blood lipid indices for metabolism dysfunction-associated fatty liver disease 
      (MAFLD) in non-overweight/obese patients with type 2 diabetes mellitus (T2DM). 
      METHODS: A retrospective observational study was conducted, including 
      non-overweight/obese patients with T2DM who visited the Fourth Hospital of Hebei 
      Medical University between August 2018 and August 2022. The low-density 
      lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) 
      ratio, the triacylglycerol-glucose index (TyG) multiplied by body mass index 
      (BMI), and TyG/HDL-C ratio were calculated. RESULTS: The study involved 190 
      participants, of whom 34 were diagnosed with MAFLD (24 males and 10 females), 
      while 156 did not have MAFLD (64 males and 92 females). Multivariable analysis 
      revealed that aspartate transaminase (AST) (OR=1.216, 95% CI: 1.059-1.374, 
      P=0.006), blood uric acid (BUA) (OR=1.017, 95% CI: 1.002-1.032, P=0.022), TyG*BMI 
      (OR=1.231, 95% CI: 1.051-1.442, P=0.010), and TyG/HDL-C (OR=3.162, 95% CI: 
      1.228-8.141, P=0.017) were independently associated with MAFLD. The TyG*BMI index 
      exhibited an area under the ROC curve (AUC) of 0.812, with 91.2% sensitivity and 
      69.2% specificity for MAFLD. The TyG/HDL-C index had an AUC of 0.929, with 85.3% 
      sensitivity and 88.5% specificity for MAFLD. CONCLUSION: The results indicate 
      that TyG*BMI and TyG/HDL-C are independently associated with MAFLD in 
      non-overweight/obese patients with T2DM.
CI  - (c) 2023 Gao et al.
FAU - Gao, Qian
AU  - Gao Q
AUID- ORCID: 0000-0002-9800-4805
AD  - Department of Endocrine and Metabolic Diseases, The Fourth Hospital of Hebei 
      Medical University, Shijiazhuang, 050000, People's Republic of China.
FAU - Feng, Lei
AU  - Feng L
AD  - Department of Endocrine and Metabolic Diseases, The Fourth Hospital of Hebei 
      Medical University, Shijiazhuang, 050000, People's Republic of China.
FAU - Zhou, Weiling
AU  - Zhou W
AUID- ORCID: 0000-0003-0434-8939
AD  - Department of Endocrine and Metabolic Diseases, The Fourth Hospital of Hebei 
      Medical University, Shijiazhuang, 050000, People's Republic of China.
FAU - Li, Xiaoli
AU  - Li X
AUID- ORCID: 0000-0003-4783-0848
AD  - Department of Endocrine and Metabolic Diseases, The Fourth Hospital of Hebei 
      Medical University, Shijiazhuang, 050000, People's Republic of China.
FAU - Yin, Lanzi
AU  - Yin L
AUID- ORCID: 0000-0002-1120-555X
AD  - Department of Endocrine and Metabolic Diseases, The Fourth Hospital of Hebei 
      Medical University, Shijiazhuang, 050000, People's Republic of China.
FAU - Wang, Yuan
AU  - Wang Y
AD  - Department of Endocrine and Metabolic Diseases, The Fourth Hospital of Hebei 
      Medical University, Shijiazhuang, 050000, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20230807
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC10416783
OTO - NOTNLM
OT  - HDL-C
OT  - LDL-C
OT  - TyG
OT  - body mass index
OT  - cholesterol
OT  - metabolism dysfunction-associated fatty liver disease
OT  - obesity
OT  - type 2 diabetes mellitus
COIS- The authors declare that they have no competing interests in this work.
EDAT- 2023/08/14 06:42
MHDA- 2023/08/14 06:43
PMCR- 2023/08/07
CRDT- 2023/08/14 04:52
PHST- 2023/04/20 00:00 [received]
PHST- 2023/07/30 00:00 [accepted]
PHST- 2023/08/14 06:43 [medline]
PHST- 2023/08/14 06:42 [pubmed]
PHST- 2023/08/14 04:52 [entrez]
PHST- 2023/08/07 00:00 [pmc-release]
AID - 418020 [pii]
AID - 10.2147/DMSO.S418020 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2023 Aug 7;16:2345-2354. doi: 10.2147/DMSO.S418020. 
      eCollection 2023.