PMID- 37577044
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230815
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 16
DP  - 2023
TI  - Effects of Glycemic Variability on Regulatory T Cells in Patients with Type 2 
      Diabetes and Kidney Disease.
PG  - 2365-2375
LID - 10.2147/DMSO.S413407 [doi]
AB  - PURPOSE: To investigate the pathogenesis of diabetic kidney disease (DKD) in type 
      2 diabetes mellitus (T2DM), we evaluated the effects of short-term glycemic 
      variability (GV) on the profile of T cell subpopulations. METHODS: A total of 47 
      T2DM patients with normoalbuminuria, 47 microalbuminuria, and 49 macroalbuminuria 
      were enrolled. The continuous glucose monitoring (CGM) determined the GV of 
      enrolled patients. Flow cytometry was used to determine the proportion of T cell 
      subpopulations. RESULTS: The frequency of T helper (Th) 17 and Th1 cells 
      significantly increased while regulatory T cells (Tregs) significantly decreased 
      in the macroalbuminuria group compared to normoalbuminuria and microalbuminuria 
      groups (P < 0.01). The suppressive function of Tregs was significantly lower in 
      the macroalbuminuria group than the normoalbuminuria group (P < 0.05). Compared 
      with the normoalbuminuria group, the mean amplitude of glucose excursions (MAGE) 
      of the macroalbuminuria group was significantly higher (P<0.05). Furthermore, 
      there were negative associations between the proportion of Tregs and MAGE. 
      CONCLUSIONS: Increased GV could decrease the proportion of Tregs and may impair 
      their function. This may lead to increases in Th1 and Th17 cells, and some 
      inflammatory cytokines, which might contribute to the development and progression 
      of DKD in T2DM.
CI  - (c) 2023 Gu et al.
FAU - Gu, Qing-Wei
AU  - Gu QW
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, 210006, People's Republic of China.
FAU - Sun, Qi
AU  - Sun Q
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, 210006, People's Republic of China.
FAU - Wang, Jie
AU  - Wang J
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, 210006, People's Republic of China.
FAU - Gu, Wen-Sha
AU  - Gu WS
AUID- ORCID: 0000-0003-2857-4826
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, 210006, People's Republic of China.
FAU - Wang, Wei
AU  - Wang W
AUID- ORCID: 0000-0002-4750-0139
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, 210006, People's Republic of China.
FAU - Mao, Xiao-Ming
AU  - Mao XM
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, 210006, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20230808
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC10423000
OTO - NOTNLM
OT  - diabetic kidney disease
OT  - glycemic variability
OT  - inflammatory cytokines
OT  - regulatory T cells
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflicts of interest that could be perceived as 
      prejudicing the impartiality of this study.
EDAT- 2023/08/14 06:42
MHDA- 2023/08/14 06:43
PMCR- 2023/08/08
CRDT- 2023/08/14 04:52
PHST- 2023/03/21 00:00 [received]
PHST- 2023/08/03 00:00 [accepted]
PHST- 2023/08/14 06:43 [medline]
PHST- 2023/08/14 06:42 [pubmed]
PHST- 2023/08/14 04:52 [entrez]
PHST- 2023/08/08 00:00 [pmc-release]
AID - 413407 [pii]
AID - 10.2147/DMSO.S413407 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2023 Aug 8;16:2365-2375. doi: 10.2147/DMSO.S413407. 
      eCollection 2023.