PMID- 37577341
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230928
IS  - 2192-3183 (Electronic)
IS  - 2192-3183 (Linking)
VI  - 12
IP  - 4
DP  - 2023 Oct
TI  - Gastric neuroendocrine carcinoma presenting complete durable response by 
      nivolumab treatment for multiple metastases and radiotherapy to oligoprogressive 
      metastasis.
PG  - 268-273
LID - 10.1007/s13691-023-00611-z [doi]
AB  - Gastric neuroendocrine carcinomas (NEC) are highly aggressive cancer with dismal 
      prognosis. Platinum-based chemotherapy is used as the first-line treatment for 
      this entity. However, there are no established therapeutic guidelines for 
      platinum-resistant gastric NEC. We herein report a patient with metastatic 
      gastric NEC who achieved durable and complete response to nivolumab with 
      radiotherapy for oligoprogressive metastasis. A 70-year-old male patient had 
      recurrences of resected gastric NEC, involving the liver and lymph nodes. His 
      disease became refractory to cisplatin and etoposide combination therapy, after 
      which he was treated with nivolumab. All the tumors showed marked shrinkage. 
      However, 1 year after starting nivolumab, one metastatic lesion of the liver 
      began to enlarge, and radiotherapy was performed to the lesion. Thereafter, a 
      complete response was obtained, which has been maintained without any treatment 
      for the past 2 years.
CI  - (c) The Author(s) under exclusive licence to The Japan Society of Clinical Oncology 
      2023. Springer Nature or its licensor (e.g. a society or other partner) holds 
      exclusive rights to this article under a publishing agreement with the author(s) 
      or other rightsholder(s); author self-archiving of the accepted manuscript 
      version of this article is solely governed by the terms of such publishing 
      agreement and applicable law.
FAU - Seyama, Yusuke
AU  - Seyama Y
AD  - Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba, Ibaraki 305-8575 Japan. GRID: grid.20515.33. ISNI: 0000 0001 
      2369 4728
FAU - Yamada, Takeshi
AU  - Yamada T
AUID- ORCID: 0000-0001-7848-5827
AD  - Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba, Ibaraki 305-8575 Japan. GRID: grid.20515.33. ISNI: 0000 0001 
      2369 4728
FAU - Suzuki, Hirosumi
AU  - Suzuki H
AD  - Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba, Ibaraki 305-8575 Japan. GRID: grid.20515.33. ISNI: 0000 0001 
      2369 4728
FAU - Fukuda, Satoshi
AU  - Fukuda S
AD  - Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba, Ibaraki 305-8575 Japan. GRID: grid.20515.33. ISNI: 0000 0001 
      2369 4728
FAU - Tsuji, Miki
AU  - Tsuji M
AD  - Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba, Ibaraki 305-8575 Japan. GRID: grid.20515.33. ISNI: 0000 0001 
      2369 4728
FAU - Niisato, Yusuke
AU  - Niisato Y
AD  - Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba, Ibaraki 305-8575 Japan. GRID: grid.20515.33. ISNI: 0000 0001 
      2369 4728
FAU - Hirose, Suguru
AU  - Hirose S
AD  - Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba, Ibaraki 305-8575 Japan. GRID: grid.20515.33. ISNI: 0000 0001 
      2369 4728
FAU - Yamamoto, Yoshiyuki
AU  - Yamamoto Y
AD  - Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba, Ibaraki 305-8575 Japan. GRID: grid.20515.33. ISNI: 0000 0001 
      2369 4728
FAU - Moriwaki, Toshikazu
AU  - Moriwaki T
AD  - Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba, Ibaraki 305-8575 Japan. GRID: grid.20515.33. ISNI: 0000 0001 
      2369 4728
FAU - Hyodo, Ichinosuke
AU  - Hyodo I
AD  - Department of Gastrointestinal Medical Oncology, National Hospital Organization 
      Shikoku Cancer Center, Matsuyama, Ehime Japan. GRID: grid.415740.3. ISNI: 0000 
      0004 0618 8403
LA  - eng
PT  - Journal Article
DEP - 20230512
PL  - Singapore
TA  - Int Cancer Conf J
JT  - International cancer conference journal
JID - 101734231
PMC - PMC10421835
OTO - NOTNLM
OT  - Gastric neuroendocrine carcinoma
OT  - Nivolumab
OT  - Oligometastasis
OT  - Radiotherapy
COIS- Conflict of interestI.H. serves as a consultant to Asahi Kasei, Ono, Chugai, 
      Taiho, and Eisai pharmaceutical companies. The other authors declare that they 
      have no conflict of interest.
EDAT- 2023/08/14 06:43
MHDA- 2023/08/14 06:44
PMCR- 2024/05/12
CRDT- 2023/08/14 04:57
PHST- 2023/01/24 00:00 [received]
PHST- 2023/04/24 00:00 [accepted]
PHST- 2024/05/12 00:00 [pmc-release]
PHST- 2023/08/14 06:44 [medline]
PHST- 2023/08/14 06:43 [pubmed]
PHST- 2023/08/14 04:57 [entrez]
AID - 611 [pii]
AID - 10.1007/s13691-023-00611-z [doi]
PST - epublish
SO  - Int Cancer Conf J. 2023 May 12;12(4):268-273. doi: 10.1007/s13691-023-00611-z. 
      eCollection 2023 Oct.