PMID- 3757772
OWN - NLM
STAT- MEDLINE
DCOM- 19861030
LR  - 20190903
IS  - 0376-8716 (Print)
IS  - 0376-8716 (Linking)
VI  - 17
IP  - 4
DP  - 1986 Jul
TI  - Development of morphine tolerance under tonic control of brain oxytocin.
PG  - 369-75
AB  - Acute morphine tolerance was induced in mice by subcutaneous (s.c.) injection of 
      a high dose (30 or 100 mg/kg) of morphine. The degree of tolerance was estimated 
      5 h later. Intracerebroventricular (i.c.v.) injection of graded doses of oxytocin 
      (OXT) dose-dependently attenuated the development of tolerance. i.c.v. injection 
      of a specific anti-OXT serum, on the other hand, facilitated the development of 
      tolerance. Neither OXT nor anti-OXT serum had any effect on the pain sensitivity 
      in morphine-naive mice; nor did these treatments modify the antinociceptive 
      action of a single morphine treatment. It is concluded that the endogenous OXT of 
      the mouse brain is normally involved in the adaptive response of the organism, 
      leading to the development of morphine tolerance.
FAU - Kovacs, G L
AU  - Kovacs GL
FAU - Sarnyai, Z
AU  - Sarnyai Z
FAU - Szabo, G
AU  - Szabo G
FAU - Telegdy, G
AU  - Telegdy G
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 0 (Immune Sera)
RN  - 50-56-6 (Oxytocin)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - *Adaptation, Physiological
MH  - Animals
MH  - Brain/physiology
MH  - Drug Tolerance
MH  - Immune Sera/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Morphine/*pharmacology
MH  - Oxytocin/immunology/*physiology
MH  - Pain/physiopathology
EDAT- 1986/07/01 00:00
MHDA- 1986/07/01 00:01
CRDT- 1986/07/01 00:00
PHST- 1986/07/01 00:00 [pubmed]
PHST- 1986/07/01 00:01 [medline]
PHST- 1986/07/01 00:00 [entrez]
AID - 0376-8716(86)90087-6 [pii]
AID - 10.1016/0376-8716(86)90087-6 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 1986 Jul;17(4):369-75. doi: 10.1016/0376-8716(86)90087-6.