PMID- 37578178
OWN - NLM
STAT- Publisher
LR  - 20230814
IS  - 1938-2391 (Electronic)
IS  - 1081-597X (Linking)
VI  - 39
IP  - 8
DP  - 2023 Aug
TI  - Clinical Characteristics and Tear Film Biomarkers in Patients With Chronic Dry 
      Eye Disease After Femtosecond Laser-Assisted Laser in Situ Keratomileusis.
PG  - 556-563
LID - 10.3928/1081597X-20230717-02 [doi]
AB  - PURPOSE: To investigate clinical characteristics and tear film biomarkers of 
      patients with chronic dry eye disease (DED) following femtosecond laser-assisted 
      laser in situ keratomileusis (FS-LASIK). METHODS: Patients were divided into the 
      chronic DED after FS-LASIK (n = 36), DED without FS-LASIK (n = 39), and normal 
      control (without FS-LASIK; n = 34) groups. Dry eye, pain, and 
      psychological-related symptoms were evaluated using the Ocular Surface Disease 
      Index (OSDI), Numerical Rating Scale (NRS), Neuropathic Pain Symptom Inventory 
      Modified for the Eye (NPSI-Eye), and Hamilton Anxiety Rating Scale (HAMA) 
      questionnaires. Ocular surface parameters, tear cytokines, and neuropeptide 
      concentrations were evaluated with specific tests. RESULTS: The DED after 
      FS-LASIK group showed higher corneal fluorescein staining scores, but lower OSDI 
      and NPSI-Eye scores than the DED without FS-LASIK group (all P < .05). Corneal 
      sensitivity and nerve density decreased in the DED after FS-LASIK group (all P < 
      .01). Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 
      (IL)-17A, IL-23, alpha-melanocyte stimulating hormone (alpha-MSH), oxytocin, and 
      substance P levels were highest in the DED after FS-LASIK group, followed by the 
      DED without FS-LASIK and normal control groups (all P < .05). Interferon-gamma and 
      neurotensin levels were only significantly higher in the DED after FS-LASIK group 
      (all P < .05). CONCLUSIONS: Patients with chronic DED after FS-LASIK showed 
      milder ocular symptoms, greater epithelial damage, and higher levels of tear 
      inflammatory cytokines and neuropeptides than patients with DED without FS-LASIK, 
      indicating that the nervous and immune systems may play significant roles in 
      FS-LASIK-related chronic DED development. [J Refract Surg. 2023;39(8):556-563.].
FAU - Zhao, Lu
AU  - Zhao L
FAU - Zhang, Yu
AU  - Zhang Y
FAU - Duan, Hongyu
AU  - Duan H
FAU - Yang, Tingting
AU  - Yang T
FAU - Zhou, Yifan
AU  - Zhou Y
FAU - Ma, Baikai
AU  - Ma B
FAU - Chen, Yueguo
AU  - Chen Y
FAU - Qi, Hong
AU  - Qi H
LA  - eng
PT  - Journal Article
DEP - 20230801
PL  - United States
TA  - J Refract Surg
JT  - Journal of refractive surgery (Thorofare, N.J. : 1995)
JID - 9505927
SB  - IM
EDAT- 2023/08/14 12:43
MHDA- 2023/08/14 12:43
CRDT- 2023/08/14 08:23
PHST- 2023/08/14 12:43 [medline]
PHST- 2023/08/14 12:43 [pubmed]
PHST- 2023/08/14 08:23 [entrez]
AID - 10.3928/1081597X-20230717-02 [doi]
PST - ppublish
SO  - J Refract Surg. 2023 Aug;39(8):556-563. doi: 10.3928/1081597X-20230717-02. Epub 
      2023 Aug 1.