PMID- 37578581
OWN - NLM
STAT- MEDLINE
DCOM- 20230908
LR  - 20230908
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 42
DP  - 2023 Sep
TI  - Joint effect of whole blood metals exposure with dyslipidemia in representative 
      US adults in NHANES 2011-2020.
PG  - 96604-96616
LID - 10.1007/s11356-023-28903-0 [doi]
AB  - With little knowledge on the joint effects of metal exposure on dyslipidemia, we 
      aimed to investigate the relationship between exposure to metal and dyslipidemia 
      among US adults based on the National Health and Nutrition Examination Survey 
      (NHANES). Based on the five NHANES waves (2011-2020), we selected five metals in 
      blood as exposure, namely, cadmium (Cd), lead (Pb), total mercury (Hg), manganese 
      (Mn), and selenium (Se), which were detected by inductively coupled plasma mass 
      spectrometry. Survey-multivariable logistic regression, generalized weighted 
      quantile sum (WQS), and Bayesian kernel machine regression (BKMR) were performed 
      to determine whether dyslipidemia was associated with single metals or mixed 
      metals. Our study included 12,526 participants aged from 20 to 80, representing 
      577.1 million non-institutionalized US adults. We found a positive association 
      between several metals including Pb [adjusted odds ratio (AOR) = 1.332, 95%CI: 
      1.165, 1.522], total Hg (AOR = 1.264, 95%CI: 1.120, 1.427), Mn (AOR = 1.181, 
      95%CI: 1.046, 1.334), and Se (AOR = 1.771, 95%CI: 1.576, 1.992) and dyslipidemia. 
      According to the WQS approach, metal mixtures were positively associated with 
      dyslipidemia (AOR: 1.310, 95%CI: 1.216, 1.411) after a full-model adjustment. As 
      is shown in the BKMR model, mixed metals tended to be positively associated with 
      dyslipidemia ratios in a significant manner. Females, non-Hispanic White 
      populations, people aged over 60, and those who did a little physical activity 
      had a greater risk for dyslipidemia. Our findings suggest metals including Cd, 
      Pb, Hg, Mn, and Se and their combinations may adversely affect dyslipidemia among 
      US adults. Due to the cross-sectional nature of the study, it is possible that 
      reverse causation may exist.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Liang, Jing-Hong
AU  - Liang JH
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China, 510080.
FAU - Pu, Ying-Qi
AU  - Pu YQ
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China, 510080.
FAU - Liu, Mei-Ling
AU  - Liu ML
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China, 510080.
FAU - Hu, Li-Xin
AU  - Hu LX
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China, 510080.
FAU - Bao, Wen-Wen
AU  - Bao WW
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China, 510080.
FAU - Zhang, Yu-Shan
AU  - Zhang YS
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China, 510080.
FAU - Kakaer, Aerziguli
AU  - Kakaer A
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China, 510080.
FAU - Zhao, Yu
AU  - Zhao Y
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China, 510080.
FAU - Chen, Yi-Can
AU  - Chen YC
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China, 510080.
FAU - Pu, Xue-Ya
AU  - Pu XY
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China, 510080.
FAU - Huang, Shao-Yi
AU  - Huang SY
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China, 510080.
FAU - Jiang, Nan
AU  - Jiang N
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China, 510080.
FAU - Huang, Shan
AU  - Huang S
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China, 510080.
FAU - Dong, Guang-Hui
AU  - Dong GH
AD  - Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, 
      Guangdong Provincial Engineering Technology Research Center of Environmental and 
      Health Risk Assessment, Department of Occupational and Environmental Health, 
      School of Public Health, Sun Yat-sen University, Guangzhou, People's Republic of 
      China.
FAU - Chen, Ya-Jun
AU  - Chen YJ
AUID- ORCID: 0000-0003-3132-2945
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China, 510080. chenyajun68@yeah.net.
LA  - eng
PT  - Journal Article
DEP - 20230814
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 00BH33GNGH (Cadmium)
RN  - 2P299V784P (Lead)
RN  - 42Z2K6ZL8P (Manganese)
RN  - H6241UJ22B (Selenium)
RN  - FXS1BY2PGL (Mercury)
RN  - 0 (Metals, Heavy)
SB  - IM
MH  - Female
MH  - Humans
MH  - Adult
MH  - Middle Aged
MH  - Aged
MH  - Cadmium
MH  - Nutrition Surveys
MH  - Bayes Theorem
MH  - Cross-Sectional Studies
MH  - Lead
MH  - Manganese
MH  - *Selenium
MH  - *Mercury
MH  - *Metals, Heavy
OTO - NOTNLM
OT  - Blood metals
OT  - Dyslipidemia
OT  - General adults
OT  - Joint effect
OT  - NHANES
EDAT- 2023/08/14 12:43
MHDA- 2023/09/08 06:43
CRDT- 2023/08/14 11:25
PHST- 2023/03/07 00:00 [received]
PHST- 2023/07/17 00:00 [accepted]
PHST- 2023/09/08 06:43 [medline]
PHST- 2023/08/14 12:43 [pubmed]
PHST- 2023/08/14 11:25 [entrez]
AID - 10.1007/s11356-023-28903-0 [pii]
AID - 10.1007/s11356-023-28903-0 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Sep;30(42):96604-96616. doi: 
      10.1007/s11356-023-28903-0. Epub 2023 Aug 14.