PMID- 37579199
OWN - NLM
STAT- MEDLINE
DCOM- 20231006
LR  - 20231006
IS  - 1522-726X (Electronic)
IS  - 1522-1946 (Linking)
VI  - 102
IP  - 4
DP  - 2023 Oct
TI  - Outcomes of transcatheter edge-to-edge repair for atrial functional mitral 
      regurgitation: A meta-analysis of observational studies.
PG  - 751-760
LID - 10.1002/ccd.30806 [doi]
AB  - BACKGROUND: Transcatheter edge-to-edge repair (TEER) may have potential benefits 
      in the treatment of atrial functional mitral regurgitation (AFMR), but robust 
      evidence is currently lacking. We conducted a systematic review and meta-analysis 
      to investigate the clinical outcomes of TEER for AFMR, including comparisons to 
      ventricular functional MR (VFMR). METHODS: MEDLINE and EMBASE were searched 
      through January 2023 to identify studies eligible for analysis. The primary 
      outcome was postprocedural MR severity. Postprocedural New York Heart Association 
      (NYHA) functional class classification and all-cause mortality were also 
      evaluated. Outcomes were stratified into short term (postprocedure to 6 months) 
      and long term (6 months to 2 years). RESULTS: A total of eight observational 
      studies met the inclusion criteria, enrolling 539 AFMR and 3486 VFMR patients. 
      Postprocedural MR grade </=2 in the AFMR group was observed in 93.7% (454/491 
      patients; 95% confidence interval (CI), 91.1%-96.2%, I(2)  = 24.3%) and 97.1% 
      (89/93 patients; 95% CI, 92.9%-100%, I(2)  = 26.4%) in short- and long-term 
      follow-up, respectively. There was no difference in the rates of postprocedural 
      MR grade </=2 between AFMR and VFMR either in short-term (risk ratio [RR], 1.00 
      [95% CI, 0.95-1.06]; p = 0.90; I(2)  = 53%) or long-term follow-up (RR, 1.08 [95% 
      CI, 0.89-1.32]; p = 0.44; I(2)  = 22%). Similarly, no difference was observed 
      between AFMR and VFMR in the rates of postprocedural NYHA class </=2 or all-cause 
      mortality. CONCLUSION: TEER provides similar clinical outcomes for AFMR and VFMR. 
      A high rate of MR grade </=2 was observed in patients at both short- and long-term 
      follow-ups. Further prospective studies with TEER versus medical therapy and/or 
      rhythm control for AFMR are warranted.
CI  - (c) 2023 Wiley Periodicals LLC.
FAU - Hamada, Seiji
AU  - Hamada S
AD  - Imperial College London, School of Public Health, London, UK.
FAU - Ueyama, Hiroki
AU  - Ueyama H
AD  - Division of Cardiology, Emory University School of Medicine, Georgia, Atlanta, 
      USA.
FAU - Aikawa, Tadao
AU  - Aikawa T
AD  - Department of Cardiology, Juntendo University Urayasu Hospital, Urayasu, Japan.
FAU - Kampaktsis, Polydoros N
AU  - Kampaktsis PN
AD  - Division of Cardiology, Columbia University Irving Medical Center, New York City, 
      New York, USA.
FAU - Misumida, Naoki
AU  - Misumida N
AUID- ORCID: 0000-0001-8985-8756
AD  - Division of Cardiovascular Medicine, Gill Heart and Vascular Institute, 
      University of Kentucky, Lexington, Kentucky, USA.
FAU - Takagi, Hisato
AU  - Takagi H
AUID- ORCID: 0000-0002-5594-8072
AD  - Department of Cardiovascular Surgery, Shizuoka Medical Center, Shizuoka, Japan.
FAU - Kuno, Toshiki
AU  - Kuno T
AUID- ORCID: 0000-0002-2487-8366
AD  - Department of Cardiology, Montefiore Medical Center, Albert Einstein College of 
      Medicine, New York City, New York, USA.
AD  - Department of Cardiology, Jacobi Medical Center, Albert Einstein College of 
      Medicine, New York, USA.
FAU - Latib, Azeem
AU  - Latib A
AUID- ORCID: 0000-0001-9035-343X
AD  - Department of Cardiology, Montefiore Medical Center, Albert Einstein College of 
      Medicine, New York City, New York, USA.
LA  - eng
GR  - 22K15867/JSPS KAKENHI/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20230814
PL  - United States
TA  - Catheter Cardiovasc Interv
JT  - Catheterization and cardiovascular interventions : official journal of the 
      Society for Cardiac Angiography & Interventions
JID - 100884139
SB  - IM
MH  - Humans
MH  - *Atrial Fibrillation
MH  - *Mitral Valve Insufficiency/diagnostic imaging/surgery
MH  - Prospective Studies
MH  - Treatment Outcome
MH  - Heart Atria
MH  - *Heart Valve Prosthesis Implantation/adverse effects
OTO - NOTNLM
OT  - MitraClip
OT  - PASCAL
OT  - atrial functional mitral regurgitation
OT  - transcatheter edge-to-edge repair
EDAT- 2023/08/14 18:42
MHDA- 2023/10/06 06:43
CRDT- 2023/08/14 15:32
PHST- 2023/06/28 00:00 [received]
PHST- 2023/07/28 00:00 [accepted]
PHST- 2023/10/06 06:43 [medline]
PHST- 2023/08/14 18:42 [pubmed]
PHST- 2023/08/14 15:32 [entrez]
AID - 10.1002/ccd.30806 [doi]
PST - ppublish
SO  - Catheter Cardiovasc Interv. 2023 Oct;102(4):751-760. doi: 10.1002/ccd.30806. Epub 
      2023 Aug 14.