PMID- 37579588
OWN - NLM
STAT- MEDLINE
DCOM- 20230920
LR  - 20230920
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 263
DP  - 2023 Sep 15
TI  - Liver enzymes mediate the association between aldehydes co-exposure and 
      hypertriglyceridemia.
PG  - 115346
LID - S0147-6513(23)00850-3 [pii]
LID - 10.1016/j.ecoenv.2023.115346 [doi]
AB  - Aldehydes are recognized environmental toxicants that may affect lipid 
      metabolism. For instance, acrolein has been found to increase serum triglyceride 
      (TG) levels exclusively. However, it remains unclear whether other aldehydes are 
      also associated with hypertriglyceridemia (HTG), and what mechanisms may be 
      involved. This cross-sectional study analyzed data from the National Health and 
      Nutrition Examination Survey (NHANES, 2013-2014) to identify associations between 
      serum aldehydes, liver enzymes, and HTG. Serum aldehydes included crotonaldehyde 
      (CRAL), propanaldehyde (3AL), butyraldehyde (4AL), pentanaldehyde (5AL), 
      isopentanaldehyde (I5AL), and heptanaldehyde (7AL). Liver enzymes included 
      alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline 
      phosphatase (ALP), and gamma-glutamyltransferase (GGT). HTG was defined as 
      fasting TG levels >/= 1.7 mmol/L. Aldehyde co-exposure was quantified using 
      weighted quantile sum (WQS) regression and Bayesian kernel machine regression 
      (BKMR), while mediation analysis was performed to investigate the role of liver 
      enzymes. Among 1474 participants (mean age 38.6 years, male 50.0%), 426 were 
      diagnosed with HTG. 4AL, 5AL, I5AL, and 7AL were shown to be positively 
      associated with HTG (all P values <0.05). Aldehydes co-exposure was also 
      positively associated with HTG (OR 1.706, 95%CI 1.299-2.240), with 5AL 
      contributing the highest weight (35.3%). Furthermore, aldehydes co-exposure 
      showed positive associations with ALT, AST, and GGT (all P values <0.05), and all 
      four liver enzymes were positively associated with HTG (all P values <0.05). 
      Mediation analysis revealed that liver enzymes (ALT, AST, and GGT) may mediate 
      the associations of 5AL and 7AL with HTG (all P values <0.05). This study 
      identified a positive association between aldehyde co-exposure and HTG, which may 
      be partially mediated by liver enzymes.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Li, Duanbin
AU  - Li D
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310000, Zhejiang, People's Republic of China; Key Laboratory 
      of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, 
      Hangzhou 310000, Zhejiang, People's Republic of China.
FAU - Chen, Zhezhe
AU  - Chen Z
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310000, Zhejiang, People's Republic of China; Key Laboratory 
      of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, 
      Hangzhou 310000, Zhejiang, People's Republic of China.
FAU - Shan, Yu
AU  - Shan Y
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310000, Zhejiang, People's Republic of China; Key Laboratory 
      of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, 
      Hangzhou 310000, Zhejiang, People's Republic of China.
FAU - Hu, Tianli
AU  - Hu T
AD  - Department of Cardiology, The Fourth Affiliated Hospital, College of Medicine, 
      Zhejiang University, Yiwu 322000, Zhejiang, People's Republic of China.
FAU - Hong, Xulin
AU  - Hong X
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310000, Zhejiang, People's Republic of China; Key Laboratory 
      of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, 
      Hangzhou 310000, Zhejiang, People's Republic of China.
FAU - Zhu, Jun
AU  - Zhu J
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310000, Zhejiang, People's Republic of China; Key Laboratory 
      of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, 
      Hangzhou 310000, Zhejiang, People's Republic of China.
FAU - Zhu, Yunhui
AU  - Zhu Y
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310000, Zhejiang, People's Republic of China; Key Laboratory 
      of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, 
      Hangzhou 310000, Zhejiang, People's Republic of China.
FAU - Fu, Guosheng
AU  - Fu G
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310000, Zhejiang, People's Republic of China; Key Laboratory 
      of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, 
      Hangzhou 310000, Zhejiang, People's Republic of China.
FAU - Wang, Min
AU  - Wang M
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310000, Zhejiang, People's Republic of China; Key Laboratory 
      of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, 
      Hangzhou 310000, Zhejiang, People's Republic of China.
FAU - Zhang, Wenbin
AU  - Zhang W
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310000, Zhejiang, People's Republic of China; Key Laboratory 
      of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, 
      Hangzhou 310000, Zhejiang, People's Republic of China. Electronic address: 
      3313011@zju.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230812
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - 0 (Aldehydes)
SB  - IM
MH  - Humans
MH  - Male
MH  - Adult
MH  - Nutrition Surveys
MH  - Cross-Sectional Studies
MH  - Bayes Theorem
MH  - *Hypertriglyceridemia
MH  - Alanine Transaminase
MH  - gamma-Glutamyltransferase
MH  - Aspartate Aminotransferases
MH  - Aldehydes/toxicity
MH  - Liver
OTO - NOTNLM
OT  - Aldehyde
OT  - Hypertriglyceridemia
OT  - Liver
OT  - NHANES
OT  - Triglyceride
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/08/15 00:42
MHDA- 2023/09/20 06:42
CRDT- 2023/08/14 18:04
PHST- 2023/04/13 00:00 [received]
PHST- 2023/07/18 00:00 [revised]
PHST- 2023/08/06 00:00 [accepted]
PHST- 2023/09/20 06:42 [medline]
PHST- 2023/08/15 00:42 [pubmed]
PHST- 2023/08/14 18:04 [entrez]
AID - S0147-6513(23)00850-3 [pii]
AID - 10.1016/j.ecoenv.2023.115346 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2023 Sep 15;263:115346. doi: 
      10.1016/j.ecoenv.2023.115346. Epub 2023 Aug 12.