PMID- 37579623
OWN - NLM
STAT- MEDLINE
DCOM- 20230828
LR  - 20240223
IS  - 1879-0046 (Electronic)
IS  - 0376-8716 (Print)
IS  - 0376-8716 (Linking)
VI  - 250
DP  - 2023 Sep 1
TI  - Effects of ambient temperature on locomotor activity and place conditioning 
      elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety.
PG  - 110917
LID - S0376-8716(23)01155-9 [pii]
LID - 10.1016/j.drugalcdep.2023.110917 [doi]
AB  - BACKGROUND: Humans often administer psychostimulants in party or music festival 
      settings characterized by warm ambient temperatures, which may impact drug 
      effects; however, preclinical studies rarely investigate drug effects at multiple 
      ambient temperatures. Work with 3,4-methylenedioxymethamphetamine (MDMA) and 
      3,4-methylenedioxypyrovalerone (MDPV) suggests that the presence of a 
      3,4-methylenedioxy ring moiety may influence ambient temperature-dependent 
      effects. METHODS: Locomotor activity and conditioned place preference 
      dose-response curves were generated at 20+/-2 degrees C for two amphetamine analogues (MDMA 
      and methamphetamine [METH]) and two cathinone analogues (MDPV and 
      alpha-pyrrolidinopentiophenone [alphaPVP]) in mice. Effects were then redetermined at 
      29+/-2 degrees C for each drug and assay. RESULTS: All four drugs elicited dose-dependent 
      locomotor stimulation at the cool ambient temperature. At the warm ambient 
      temperature, MDMA and MDPV produced sensitization to stereotypy, whereas METH and 
      alphaPVP produced sensitization to locomotor activity. Regarding place conditioning, 
      the warm ambient environment potentiated place preference elicited by doses of 
      METH and alphaPVP that were sub-threshold in the cool ambient environment, but 
      attenuated the effects of analogous doses of MDMA and MDPV. CONCLUSIONS: These 
      studies suggest that warmer ambient temperatures may potentiate typical stimulant 
      effects for the drugs lacking the 3,4-methylenedioxy ring, but may potentiate the 
      behaviorally toxic/adverse effects for the drugs containing a 3,4-methylenedioxy 
      ring. Thus, preclinical abuse liability studies conducted at standard laboratory 
      temperatures may not fully capture the effects of psychostimulants and highlight 
      the need to model the environments in which drugs are typically used by humans.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Gannon, Brenda M
AU  - Gannon BM
AD  - Department of Pharmacology and Toxicology, College of Medicine, University of 
      Arkansas for Medical Sciences, Little Rock, AR, USA.
FAU - Fitzgerald, Lauren R
AU  - Fitzgerald LR
AD  - Department of Pharmacology and Toxicology, College of Medicine, University of 
      Arkansas for Medical Sciences, Little Rock, AR, USA.
FAU - Godwin, Christopher O
AU  - Godwin CO
AD  - Department of Pharmacology and Toxicology, College of Medicine, University of 
      Arkansas for Medical Sciences, Little Rock, AR, USA.
FAU - Hughes-Meredith, Heidi D
AU  - Hughes-Meredith HD
AD  - Department of Pharmacology and Toxicology, College of Medicine, University of 
      Arkansas for Medical Sciences, Little Rock, AR, USA.
FAU - Rice, Kenner C
AU  - Rice KC
AD  - Drug Design and Synthesis Section, Chemical Biology Research Branch, National 
      Institute on Drug Abuse, and the National Institute on Alcohol Abuse and 
      Alcoholism, National Institutes of Health, Department of Health and Human 
      Services, Bethesda, MD, USA.
FAU - Fantegrossi, William E
AU  - Fantegrossi WE
AD  - Department of Pharmacology and Toxicology, College of Medicine, University of 
      Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address: 
      WEFantegrossi@uams.edu.
LA  - eng
GR  - T32 DA022981/DA/NIDA NIH HHS/United States
GR  - Z01 DA000532/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20230808
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - 0 (Synthetic Cathinone)
SB  - IM
EIN - Drug Alcohol Depend. 2024 Mar 1;256:111129. PMID: 38395705
MH  - Animals
MH  - Male
MH  - Mice
MH  - *Central Nervous System Stimulants/adverse effects
MH  - *Conditioning, Operant/drug effects/physiology
MH  - Dose-Response Relationship, Drug
MH  - Hallucinogens/adverse effects
MH  - *Locomotion/drug effects/physiology
MH  - *N-Methyl-3,4-methylenedioxyamphetamine/adverse effects
MH  - Substance-Related Disorders/physiopathology
MH  - *Synthetic Cathinone/adverse effects
MH  - *Temperature
MH  - Disease Models, Animal
PMC - PMC10481935
MID - NIHMS1926731
OTO - NOTNLM
OT  - Ambient temperature
OT  - Cathinones
OT  - Conditioned place preference
OT  - Locomotor activity
OT  - Psychostimulants
OT  - Structure activity relationships
COIS- Declaration of Competing Interest WEF is an Associate Editor at Drug and Alcohol 
      Dependence.
EDAT- 2023/08/15 00:42
MHDA- 2023/08/22 06:42
PMCR- 2024/09/01
CRDT- 2023/08/14 18:06
PHST- 2023/05/16 00:00 [received]
PHST- 2023/07/05 00:00 [revised]
PHST- 2023/08/02 00:00 [accepted]
PHST- 2024/09/01 00:00 [pmc-release]
PHST- 2023/08/22 06:42 [medline]
PHST- 2023/08/15 00:42 [pubmed]
PHST- 2023/08/14 18:06 [entrez]
AID - S0376-8716(23)01155-9 [pii]
AID - 10.1016/j.drugalcdep.2023.110917 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2023 Sep 1;250:110917. doi: 
      10.1016/j.drugalcdep.2023.110917. Epub 2023 Aug 8.