PMID- 37579685
OWN - NLM
STAT- MEDLINE
DCOM- 20230915
LR  - 20230919
IS  - 1872-7603 (Electronic)
IS  - 0165-0378 (Linking)
VI  - 159
DP  - 2023 Sep
TI  - Characterization of progesterone-induced dendritic cells in metabolic and 
      immunologic reprogramming.
PG  - 104128
LID - S0165-0378(23)00334-0 [pii]
LID - 10.1016/j.jri.2023.104128 [doi]
AB  - The role of maternal-fetal immune tolerance in the establishment and maintenance 
      of pregnancy has been well established. Dendritic cells (DCs) as a crucial part 
      of the decidual microenvironment, have high plasticity in immunogenicity and 
      tolerogenicity. The regulatory mechanisms of DCs phenotype or function at the 
      maternal-fetal interface, however, have not been fully developed. Studies from 
      the field of immunometabolism have highlighted that the metabolic pathways of DCs 
      are closely associated with their immunity. Our previous study showed that 
      progesterone (P4) up-regulated a series of enzymes involved in DCs mitochondrial 
      oxidative phosphorylation and fatty acid metabolism. In this study, we confirmed 
      that P4 induced significant alternations in DCs metabolic pathways, promoting 
      their glycolysis, mitochondrial function, and the dependency and capacity of 
      fatty acids as mitochondrial fuel. Moreover, P4 also increased the inhibitory 
      molecule ILT4 expression on DCs and down-regulated the CD86, which may coordinate 
      their immune tolerance function in pregnancy. Together, our study helps to 
      understand the role of P4 in DCs metabolic and immunologic reprogramming and may 
      provide novel insights into the hormonal immunometabolism regulation of DCs 
      during normal pregnancy.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Liu, Su
AU  - Liu S
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Shenzhen Zhongshan Institute for Reproduction and Genetics, Shenzhen Zhongshan 
      Urology Hospital, Shenzhen, China.
FAU - Zhang, Sainan
AU  - Zhang S
AD  - State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 
      Nanjing, China.
FAU - Hong, Ling
AU  - Hong L
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Shenzhen Zhongshan Institute for Reproduction and Genetics, Shenzhen Zhongshan 
      Urology Hospital, Shenzhen, China.
FAU - Diao, Lianghui
AU  - Diao L
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Shenzhen Zhongshan Institute for Reproduction and Genetics, Shenzhen Zhongshan 
      Urology Hospital, Shenzhen, China.
FAU - Cai, Songchen
AU  - Cai S
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Shenzhen Zhongshan Institute for Reproduction and Genetics, Shenzhen Zhongshan 
      Urology Hospital, Shenzhen, China.
FAU - Yin, Tailang
AU  - Yin T
AD  - Reproductive Medical Center, Renmin Hospital of Wuhan University and Hubei Clinic 
      Research Center for Assisted Reproductive Technology and Embryonic Development, 
      Wuhan, China. Electronic address: reproductive@whu.edu.cn.
FAU - Zeng, Yong
AU  - Zeng Y
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Shenzhen Zhongshan Institute for Reproduction and Genetics, Shenzhen Zhongshan 
      Urology Hospital, Shenzhen, China. Electronic address: zengyong1966@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230803
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Humans
MH  - Pregnancy
MH  - Female
MH  - *Progesterone/metabolism
MH  - *Dendritic Cells
OTO - NOTNLM
OT  - Dendritic cells
OT  - Fatty acid metabolism
OT  - Immune tolerance
OT  - Mitochondrial function
OT  - Progesterone
COIS- Declaration of Competing Interest We declare no potential conflicts of interest 
      concerning the research, authorship, and/or publication of this article.
EDAT- 2023/08/15 00:42
MHDA- 2023/09/15 06:43
CRDT- 2023/08/14 18:08
PHST- 2023/04/06 00:00 [received]
PHST- 2023/07/19 00:00 [revised]
PHST- 2023/08/02 00:00 [accepted]
PHST- 2023/09/15 06:43 [medline]
PHST- 2023/08/15 00:42 [pubmed]
PHST- 2023/08/14 18:08 [entrez]
AID - S0165-0378(23)00334-0 [pii]
AID - 10.1016/j.jri.2023.104128 [doi]
PST - ppublish
SO  - J Reprod Immunol. 2023 Sep;159:104128. doi: 10.1016/j.jri.2023.104128. Epub 2023 
      Aug 3.