PMID- 37579973
OWN - NLM
STAT- Publisher
LR  - 20231012
IS  - 1873-4995 (Electronic)
IS  - 0168-3659 (Linking)
VI  - 362
DP  - 2023 Oct
TI  - Polysaccharide-based tumor microenvironment-responsive drug delivery systems for 
      cancer therapy.
PG  - 19-43
LID - S0168-3659(23)00517-5 [pii]
LID - 10.1016/j.jconrel.2023.08.019 [doi]
AB  - The biochemical indicators of tumor microenvironment (TME) that are different 
      from normal tissues provide the possibility for constructing intelligent drug 
      delivery systems (DDSs). Polysaccharides with good biocompatibility, 
      biodegradability, and unique biological properties are ideal materials for 
      constructing DDSs. Nanogels, micelles, organic-inorganic nanocomposites, 
      hydrogels, and microneedles (MNs) are common polysaccharide-based DDSs. 
      Polysaccharide-based DDSs enable precise control of drug delivery and release 
      processes by incorporating TME-specific biochemical indicators. The 
      classification and design strategies of polysaccharide-based TME-responsive DDSs 
      are comprehensively reviewed. The advantages and challenges of current 
      polysaccharide-based DDSs are summarized and the future directions of development 
      are foreseen. The polysaccharide-based TME-responsive DDSs are expected to 
      provide new strategies and solutions for cancer therapy and make important 
      contributions to the realization of precision medicine.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Wu, Qimeng
AU  - Wu Q
AD  - College of Chemistry and Chemical Engineering, College of Materials Science and 
      Engineering, Institute of Biomedical Materials and Engineering, Qingdao 
      University, Qingdao 266071, China.
FAU - Hu, Yang
AU  - Hu Y
AD  - Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of 
      Chemical Technology), Ministry of Education, Beijing Laboratory of Biomedical 
      Materials, College of Materials Science and Engineering, Beijing University of 
      Chemical Technology, Beijing 100029, China.
FAU - Yu, Bing
AU  - Yu B
AD  - College of Chemistry and Chemical Engineering, College of Materials Science and 
      Engineering, Institute of Biomedical Materials and Engineering, Qingdao 
      University, Qingdao 266071, China.
FAU - Hu, Hao
AU  - Hu H
AD  - College of Chemistry and Chemical Engineering, College of Materials Science and 
      Engineering, Institute of Biomedical Materials and Engineering, Qingdao 
      University, Qingdao 266071, China. Electronic address: huhao@qdu.edu.cn.
FAU - Xu, Fu-Jian
AU  - Xu FJ
AD  - Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of 
      Chemical Technology), Ministry of Education, Beijing Laboratory of Biomedical 
      Materials, College of Materials Science and Engineering, Beijing University of 
      Chemical Technology, Beijing 100029, China. Electronic address: 
      xufj@mail.buct.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230824
PL  - Netherlands
TA  - J Control Release
JT  - Journal of controlled release : official journal of the Controlled Release 
      Society
JID - 8607908
SB  - IM
OTO - NOTNLM
OT  - Cancer therapy
OT  - Drug delivery system
OT  - Polysaccharides
OT  - Stimulus-response
OT  - Tumor microenvironment
COIS- Declaration of Competing Interest The authors declare no conflict of interest.
EDAT- 2023/08/15 00:42
MHDA- 2023/08/15 00:42
CRDT- 2023/08/14 19:24
PHST- 2023/06/26 00:00 [received]
PHST- 2023/08/05 00:00 [revised]
PHST- 2023/08/11 00:00 [accepted]
PHST- 2023/08/15 00:42 [pubmed]
PHST- 2023/08/15 00:42 [medline]
PHST- 2023/08/14 19:24 [entrez]
AID - S0168-3659(23)00517-5 [pii]
AID - 10.1016/j.jconrel.2023.08.019 [doi]
PST - ppublish
SO  - J Control Release. 2023 Oct;362:19-43. doi: 10.1016/j.jconrel.2023.08.019. Epub 
      2023 Aug 24.