PMID- 37580921
OWN - NLM
STAT- MEDLINE
DCOM- 20230816
LR  - 20230816
IS  - 1011-601X (Print)
IS  - 1011-601X (Linking)
VI  - 36
IP  - 3
DP  - 2023 May
TI  - Asiatic acid ameliorates life and health span in fruit fly.
PG  - 741-748
AB  - Aging is becoming a prominent health problem in present world. Asiatic acid has 
      multiple health-protecting effects because of its variety biological function. 
      However, relation between asiatic acid and aging is still unknown. In this study, 
      fruit fly was used as model animal to illuminate anti-aging effect of asiatic 
      acid. Our results advised asiatic acid possessed efficacy of promoting health 
      span, as represented by extending lifetime and enhancing locomotor activity both 
      in intrinsic and pathologically aging. In external environment, asiatic acid 
      elevated survival rate against oxidative response and starvation resistance. In 
      aspect of anti-aging mechanism, asiatic acid possessed antioxidant capacity by 
      improvement of super oxide dismutase (SOD), catalase (CAT) and glutathione 
      peroxidase (GSH-px) activities and suppression of malondialdehyde (MDA) level to 
      promote health span. In addition, asiatic acid amended energy material storage to 
      meet needs of life process. Moreover, asiatic acid inhibited acetylcholine (AChE) 
      activity to alter cholinergic system in aging process. Lastly, asiatic acid 
      upregulated peroxisome proliferator-activated receptor gamma coactivator 1 (PGC1) 
      and silence information regulator 2 (Sir2) expression in intrinsic aging. In 
      conclusion, asiatic acid exerted health-protecting potential via modulating 
      directly or indirectly antioxidant activity, cholinergic system and longevity 
      genes and could be developed into anti-aging agent.
FAU - Liu Xianchu, -
AU  - Liu Xianchu -
AD  - Institute of Physical Culture, Hunan University of Arts and Science, Changde, 
      Hunan, China.
FAU - Peng Huan, -
AU  - Peng Huan -
AD  - Xiangya Changde Hospital, Changde, Hunan, China.
FAU - Liu Ming, -
AU  - Liu Ming -
AD  - Faculty of Science, College of Furong, Hunan University of Arts and Science, 
      Changde, Hunan, China.
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - Pak J Pharm Sci
JT  - Pakistan journal of pharmaceutical sciences
JID - 9426356
RN  - 9PA5A687X5 (asiatic acid)
RN  - 0 (Antioxidants)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - 0 (Cholinergic Agents)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - 4Y8F71G49Q (Malondialdehyde)
SB  - IM
MH  - Animals
MH  - *Oxidative Stress
MH  - *Health Promotion
MH  - Antioxidants/pharmacology/metabolism
MH  - Catalase/metabolism
MH  - Superoxide Dismutase/metabolism
MH  - Cholinergic Agents/pharmacology
MH  - Glutathione Peroxidase/metabolism
MH  - Malondialdehyde/metabolism
EDAT- 2023/08/15 06:42
MHDA- 2023/08/16 06:43
CRDT- 2023/08/15 02:20
PHST- 2023/08/16 06:43 [medline]
PHST- 2023/08/15 06:42 [pubmed]
PHST- 2023/08/15 02:20 [entrez]
PST - ppublish
SO  - Pak J Pharm Sci. 2023 May;36(3):741-748.