PMID- 37582564
OWN - NLM
STAT- MEDLINE
DCOM- 20230817
LR  - 20231216
IS  - 1658-3175 (Electronic)
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 44
IP  - 8
DP  - 2023 Aug
TI  - The NLRP3 inflammasome rs35829419 C>A polymorphism is associated with type 2 
      diabetes mellitus in Saudi Arabia.
PG  - 745-750
LID - 10.15537/smj.2023.44.8.20230322 [doi]
AB  - OBJECTIVES: To investigate the frequency of NLRP3 gene rs35829419 C>A 
      single-nucleotide polymorphism (SNP) in a Saudi Arabian population from Jazan 
      (Southwest Saudi Arabia) and test its potential association with type 2 diabetes 
      mellitus (T2DM). METHODS: This case-control study included 546 volunteers (271 
      patients with T2DM and 275 healthy controls) recruited from outpatient clinics at 
      Jazan University Hospital and King Fahad Central Hospital in Jazan, Saudi Arabia, 
      between December 2021 and July 2022. Genomic DNA was extracted from all samples 
      and genotyped for the NLRP3 rs35829419 C>A SNP using TaqMan technology. The 
      association between the NLRP3 rs35829419 polymorphism and T2DM was examined using 
      logistic regression analysis. RESULTS: Overall genotype distributions were 90.5% 
      (CC), 9.3% (CA), and 0.2% (AA). The heterozygous CA genotype was more frequent in 
      T2DM group (12.2%) compared to the control group (6.5%) and logistic regression 
      analysis showed a statically significant association with T2DM risk under 
      codominant (CA versus CC; odds ratio [OR]=1.99; 95% confidence interval [CI]= 
      [1.11-3.61]; p=0.0270), and dominant (CA+AA versus CC; OR=2.05; CI=[1.16-3.75]; 
      p=0.019) models of inheritance. CONCLUSION: This study revealed the frequency of 
      NLRP3 rs35829419 C>A polymorphism in our population and showed a direct 
      correlation between having the minor allele for A and having a higher risk of 
      developing T2DM. This study highlights the significance of NLRP3 rs35829419 C>A 
      polymorphism in the pathophysiology of T2DM.
CI  - Copyright: (c) Saudi Medical Journal.
FAU - Kaabi, Yahia A
AU  - Kaabi YA
AUID- ORCID: 0000-0001-5418-5782
AD  - From the Department of Medical Laboratory Technology, Faculty of Applied Medical 
      Sciences, Jazan University, Jazan, Kingdom of Saudi Arabia.
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
RN  - 0 (Inflammasomes)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (NLRP3 protein, human)
SB  - IM
MH  - Humans
MH  - Case-Control Studies
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - Genetic Predisposition to Disease
MH  - Inflammasomes
MH  - *NLR Family, Pyrin Domain-Containing 3 Protein/genetics
MH  - Polymorphism, Single Nucleotide
MH  - Saudi Arabia/epidemiology
PMC - PMC10425621
OTO - NOTNLM
OT  - NLRP3 rs35829419 C>A SNP
OT  - Saudi Arabia
OT  - inflammasome
OT  - type 2 diabetes mellitus
EDAT- 2023/08/16 00:42
MHDA- 2023/08/17 06:43
PMCR- 2023/08/01
CRDT- 2023/08/15 20:43
PHST- 2023/04/29 00:00 [received]
PHST- 2023/06/24 00:00 [accepted]
PHST- 2023/08/17 06:43 [medline]
PHST- 2023/08/16 00:42 [pubmed]
PHST- 2023/08/15 20:43 [entrez]
PHST- 2023/08/01 00:00 [pmc-release]
AID - 44/8/745 [pii]
AID - SaudiMedJ-44-8-745 [pii]
AID - 10.15537/smj.2023.44.8.20230322 [doi]
PST - ppublish
SO  - Saudi Med J. 2023 Aug;44(8):745-750. doi: 10.15537/smj.2023.44.8.20230322.