PMID- 37583643
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231031
IS  - 1735-7020 (Print)
IS  - 2008-238X (Electronic)
IS  - 1735-7020 (Linking)
VI  - 18
IP  - 2
DP  - 2023 Apr-Jun
TI  - The Association of Human Leucocyte Antigen (HLA) Class I and II Genes with 
      Cutaneous and Visceral Leishmaniasis in Iranian Patients: A Preliminary 
      Case-Control Study.
PG  - 155-164
LID - 10.18502/ijpa.v18i2.13181 [doi]
AB  - BACKGROUND: Leishmaniasis is currently considered a re-emerging or emerging 
      infection based on the geographic region. The outcome of leishmaniasis vastly 
      depends on Leishmania-host interaction. This preliminary study aimed to show the 
      association of human leukocyte antigen (HLA) class I and II genes with healed and 
      non-healed cutaneous leishmaniasis (CL), and symptomatic and asymptomatic 
      visceral leishmaniasis (VL) compared with control groups in Iran. METHODS: 
      Ninety-five people, including 31 patients versus 64 individuals in the control 
      group, were enrolled. Among them, 20 patients had confirmed CL based on 
      amastigote observation, 10 had improved CL and 10 non-healed CL. Eleven patients 
      were suffering from confirmed VL based on direct agglutination test (Five 
      asymptomatic and six symptomatic VL cases). Besides, they were residents in an 
      endemic area of VL in the northwest of Iran. To select a control group, it was 
      ensured that they had no history of leishmaniasis. Peripheral blood samples were 
      collected from each patient. After DNA extraction, HLA typing was conducted using 
      polymerase chain reaction - sequence-specific priming (PCR-SSP). Subsequently, 
      data were statistically analyzed by SPSS. RESULTS: There was a statistical 
      relationship between the presence of HLA-A26 and CL, healed CL and the existence 
      of the B38 allele, C1 allele and symptomatic VL, as well as B1.4 allele and 
      asymptomatic VL (P<0.05). CONCLUSION: This primary finding indicates that several 
      HLA genes have a potential role in the susceptibility of Iranian people to CL and 
      VL.
CI  - Copyright (c) 2023 Eimanzadeh et al. Published by Tehran University of Medical 
      Sciences.
FAU - Eimanzadeh, Mitra
AU  - Eimanzadeh M
AD  - Department of Medical Parasitology and Mycology, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Mohebali, Mehdi
AU  - Mohebali M
AD  - Department of Medical Parasitology and Mycology, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
AD  - Center for Research of Endemic Parasites of Iran (CREPI), Tehran University of 
      Medical Sciences, Tehran, Iran.
FAU - Zarrabi, Morteza
AU  - Zarrabi M
AD  - Royan Stem Cell Technology, Cord Blood Bank, Tehran, Iran.
FAU - Foroushani, Abbas Rahimi
AU  - Foroushani AR
AD  - Department of Epidemiology and Biostatics, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Kazemi, Mohammad
AU  - Kazemi M
AD  - Royan Stem Cell Technology, Cord Blood Bank, Tehran, Iran.
FAU - Hajjaran, Homa
AU  - Hajjaran H
AD  - Department of Medical Parasitology and Mycology, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Zarei, Zabih
AU  - Zarei Z
AD  - Department of Medical Parasitology and Mycology, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Kakooei, Zahra
AU  - Kakooei Z
AD  - Department of Medical Parasitology and Mycology, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Akhoundi, Behnaz
AU  - Akhoundi B
AD  - Department of Medical Parasitology and Mycology, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Parasitol
JT  - Iranian journal of parasitology
JID - 101464309
PMC - PMC10423905
OTO - NOTNLM
OT  - Genes
OT  - HLA
OT  - Immunology
OT  - Iran
OT  - Leishmaniasis
COIS- Conflict of Interest The authors declare that there is no conflict of interest.
EDAT- 2023/08/16 06:42
MHDA- 2023/08/16 06:43
PMCR- 2023/04/01
CRDT- 2023/08/16 03:49
PHST- 2022/09/14 00:00 [received]
PHST- 2023/01/19 00:00 [accepted]
PHST- 2023/08/16 06:43 [medline]
PHST- 2023/08/16 06:42 [pubmed]
PHST- 2023/08/16 03:49 [entrez]
PHST- 2023/04/01 00:00 [pmc-release]
AID - IJPA-18-155 [pii]
AID - 10.18502/ijpa.v18i2.13181 [doi]
PST - ppublish
SO  - Iran J Parasitol. 2023 Apr-Jun;18(2):155-164. doi: 10.18502/ijpa.v18i2.13181.