PMID- 37583683
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230817
IS  - 2223-3652 (Print)
IS  - 2223-3660 (Electronic)
IS  - 2223-3652 (Linking)
VI  - 13
IP  - 2
DP  - 2023 Apr 28
TI  - Risk factors for microalbuminuria in adult Tibetan patients with high-altitude 
      pulmonary hypertension: a cross-sectional study.
PG  - 336-344
LID - 10.21037/cdt-22-385 [doi]
AB  - BACKGROUND: It has been suggested that chronic hypoxia underlies the higher 
      prevalence of microalbuminuria in high-altitude residents than in sea-level 
      dwellers. This study explored the risk factors for microalbuminuria in Tibetans 
      with high-altitude pulmonary hypertension (HAPH). METHODS: This retrospective 
      cross-sectional study included adult patients with HAPH admitted to the People's 
      Hospital of Tibet Autonomous Region between November 2018 and August 2019. 
      RESULTS: One hundred and twenty patients with HAPH were included in this study, 
      and 69 patients (57.5%) had microalbuminuria. Compared with the patients without 
      microalbuminuria, the microalbuminuria group had significantly higher values for 
      age, pulmonary arterial systolic pressure (PASP), systolic blood pressure, 
      diastolic blood pressure, blood hemoglobin concentration, glycated hemoglobin, 
      serum creatinine, and serum uric acid, significantly lower values for heart rate, 
      peripheral oxygen saturation (SpO(2)), estimated glomerular filtration rate, and 
      6-min walking distance, and poorer New York Heart Association functional class 
      (P<0.05 for all variables). PASP [odds ratio (OR): 1.55; 95% CI: 1.19-2.00; 
      P=0.001] and SpO(2) (OR = 0.78; 95% CI: 0.63-0.97; P=0.02) were independently 
      associated with microalbuminuria. CONCLUSIONS: Higher PASP and lower SpO(2) were 
      independently associated with microalbuminuria in adult Tibetan patients with 
      HAPH.
CI  - 2023 Cardiovascular Diagnosis and Therapy. All rights reserved.
FAU - Yuan, Cuizhen
AU  - Yuan C
AD  - Heart Center, Peking University People's Hospital, Beijing, China.
FAU - Zhang, Qian
AU  - Zhang Q
AD  - Heart Center, Peking University People's Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20230329
PL  - China
TA  - Cardiovasc Diagn Ther
JT  - Cardiovascular diagnosis and therapy
JID - 101601613
PMC - PMC10423733
OTO - NOTNLM
OT  - Altitude hypoxia
OT  - albuminuria
OT  - oxygen saturation
OT  - pulmonary hypertension
OT  - risk factors
COIS- Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure 
      form (available 
      at https://cdt.amegroups.com/article/view/10.21037/cdt-22-385/coif). The authors 
      have no conflicts of interest to declare.
EDAT- 2023/08/16 06:43
MHDA- 2023/08/16 06:44
PMCR- 2023/04/28
CRDT- 2023/08/16 03:50
PHST- 2022/07/28 00:00 [received]
PHST- 2023/02/10 00:00 [accepted]
PHST- 2023/08/16 06:44 [medline]
PHST- 2023/08/16 06:43 [pubmed]
PHST- 2023/08/16 03:50 [entrez]
PHST- 2023/04/28 00:00 [pmc-release]
AID - cdt-13-02-336 [pii]
AID - 10.21037/cdt-22-385 [doi]
PST - ppublish
SO  - Cardiovasc Diagn Ther. 2023 Apr 28;13(2):336-344. doi: 10.21037/cdt-22-385. Epub 
      2023 Mar 29.