PMID- 37583943
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230817
IS  - 1831-4732 (Electronic)
IS  - 1831-4732 (Linking)
VI  - 21
IP  - 8
DP  - 2023 Aug
TI  - Modification of the existing maximum residue levels for difenoconazole in wheat 
      and rye.
PG  - e08207
LID - 10.2903/j.efsa.2023.8207 [doi]
LID - e08207
AB  - In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant 
      Syngenta Crop Protection AG submitted an application to the competent national 
      authority in Germany (evaluating Member State, EMS) to modify the existing 
      maximum residue levels (MRLs) for the active substance difenoconazole in wheat 
      and rye grain. The data submitted in support of the request were found sufficient 
      to derive MRL proposals for wheat and rye grain. Adequate analytical methods for 
      enforcement are available to control the residues of difenoconazole in plant 
      matrices under consideration at the validated limit of quantification (LOQ) of 
      0.01 mg/kg. The submitted data indicate no need to modify the EU MRLs in animal 
      commodities for the existing enforcement residue definition. EFSA concluded that 
      the dietary exposure to difenoconazole residues from the intake of wheat and rye 
      grain is low, noting that the impact of intended uses on the residues in animal 
      commodities and the consumer exposure could not be properly addressed. Overall, 
      the present risk assessment confirms a very narrow margin of safety for the 
      overall chronic exposure and is considered provisional, pending the submission of 
      confirmatory data on possible preferential metabolism/degradation of the four 
      stereo isomers of difenoconazole in plants and animals and the impact of 
      isomerisation on the toxicity of difenoconazole. The assessment is also affected 
      by uncertainties related to the toxicological profile of animal metabolite 
      CGA205375 and, additionally, it does not take into consideration triazole 
      derivative metabolites (TDMs).
CI  - (c) 2023 European Food Safety Authority. EFSA Journal published by Wiley-VCH GmbH 
      on behalf of European Food Safety Authority.
CN  - European Food Safety Authority (EFSA)
FAU - Bellisai, Giulia
AU  - Bellisai G
FAU - Bernasconi, Giovanni
AU  - Bernasconi G
FAU - Carrasco Cabrera, Luis
AU  - Carrasco Cabrera L
FAU - Castellan, Irene
AU  - Castellan I
FAU - Del Aguila, Monica
AU  - Del Aguila M
FAU - Ferreira, Lucien
AU  - Ferreira L
FAU - Santonja, German Giner
AU  - Santonja GG
FAU - Greco, Luna
AU  - Greco L
FAU - Jarrah, Samira
AU  - Jarrah S
FAU - Leuschner, Renata
AU  - Leuschner R
FAU - Perez, Javier Martinez
AU  - Perez JM
FAU - Miron, Ileana
AU  - Miron I
FAU - Nave, Stefanie
AU  - Nave S
FAU - Pedersen, Ragnor
AU  - Pedersen R
FAU - Reich, Hermine
AU  - Reich H
FAU - Ruocco, Silvia
AU  - Ruocco S
FAU - Santos, Miguel
AU  - Santos M
FAU - Scarlato, Alessia Pia
AU  - Scarlato AP
FAU - Theobald, Anne
AU  - Theobald A
FAU - Tiramani, Manuela
AU  - Tiramani M
FAU - Verani, Alessia
AU  - Verani A
LA  - eng
PT  - Journal Article
DEP - 20230814
PL  - United States
TA  - EFSA J
JT  - EFSA journal. European Food Safety Authority
JID - 101642076
PMC - PMC10424063
OTO - NOTNLM
OT  - MRL
OT  - TDMs
OT  - consumer risk assessment
OT  - difenoconazole
OT  - pesticide
OT  - rye
OT  - wheat
EDAT- 2023/08/16 06:43
MHDA- 2023/08/16 06:44
PMCR- 2023/08/14
CRDT- 2023/08/16 03:56
PHST- 2023/08/16 06:44 [medline]
PHST- 2023/08/16 06:43 [pubmed]
PHST- 2023/08/16 03:56 [entrez]
PHST- 2023/08/14 00:00 [pmc-release]
AID - EFS28207 [pii]
AID - 10.2903/j.efsa.2023.8207 [doi]
PST - epublish
SO  - EFSA J. 2023 Aug 14;21(8):e08207. doi: 10.2903/j.efsa.2023.8207. eCollection 2023 
      Aug.