PMID- 37585301
OWN - NLM
STAT- Publisher
LR  - 20230816
IS  - 1840-2445 (Electronic)
IS  - 1840-0132 (Linking)
VI  - 20
IP  - 2
DP  - 2023 Aug 1
TI  - The role of mesenchymal stem cells in allergic rhinitis and its relationship with 
      IL-10, plasma cells and regulatory T cells.
PG  - 175-180
LID - 10.17392/1541-23 [doi]
AB  - Aim Allergic rhinitis (AR) is an IgE-mediated inflammation of the nose. 
      Regulatory T cells (Tregs), plasma cells and inflammatory cytokines have shown to 
      play a critical role in allergic airway inflammation. The aim of the study was to 
      investigate the role of mesenchymal stem cells (MSCs) in generating Treg cells 
      and plasma cells associated with regulating interlukin-10 (IL-10) in AR model. 
      Methods Fifteen male Wistar rats (6 to 8 weeks old) were randomly divided into 
      three groups (control group, sham group, and MSCs treatment group). Ovalbumin 
      (OVA) nasal challenge was conducted daily from day 15 to 21, and MSCs (1x106) 
      were administrated intraperitoneally to OVA-sensitized rats on day 21. Sneezing 
      was observed from day 24 to 27. The rats were sacrificed on day 24 and day 27. 
      The expression of Treg and plasma cells was analysed by flow cytometry assay. The 
      level of IL-10 was analysed under ELISA assay. Results This study showed that the 
      percentage of sneezing and rubbing times significantly decreased in MSCs 
      treatment associated with the regulation of IL-10 level and plasma cell. This 
      finding was aligned with the significant increase of Treg level. Conclusion MSCs 
      administration regulates IL-10 and plasma cell-mediated immune and inflammatory 
      responses while increasing Treg cell production. MSCs may be a promising 
      therapeutic target for treating Treg-mediated allergic diseases.
CI  - Copyright(c) by the Medical Assotiation of Zenica-Doboj Canton.
FAU - Munir, Delfitri
AU  - Munir D
AD  - Departement of Doctoral Degree Program, Faculty of Medicine, Universitas Sumatera 
      Utara, Medan, Indonesia.
AD  - Departement of Otorhinolaryngology-Head and Neck Surgery, Universitas Sumatera 
      Utara, Medan, Indonesia.
AD  - Pusat Unggulan Iptek (PUI) Tissue Engineering, Universitas Sumatera Utara, Medan, 
      Indonesia.
FAU - Pahlevi Nasution, Iqbal
AU  - Pahlevi Nasution I
AD  - Departement of Paediatrics, Faculty of Medicine, Universitas Sumatera Utara, 
      Medan, Indonesia.
AD  - Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
FAU - Restimulia, Lia
AU  - Restimulia L
AD  - Departement of Otorhinolaryngology-Head and Neck Surgery, Universitas Sumatera 
      Utara, Medan, Indonesia.
AD  - Pusat Unggulan Iptek (PUI) Tissue Engineering, Universitas Sumatera Utara, Medan, 
      Indonesia.
AD  - Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
FAU - Putra, Agung
AU  - Putra A
AD  - Stem Cell and Cancer Research, Faculty of Medicine, Universitas Islam Sultan 
      Agung, Semarang, Indonesia.
AD  - Department of Pathological Anatomy, Faculty of Medicine, Universitas Islam Sultan 
      Agung, Semarang, Indonesia.
AD  - Department of Postgraduate Biomedical Science, Faculty of Medicine, Universitas 
      Islam Sultan Agung, Semarang, Indonesia.
FAU - Amalina, Nur Dina
AU  - Amalina ND
AD  - Stem Cell and Cancer Research, Faculty of Medicine, Universitas Islam Sultan 
      Agung, Semarang, Indonesia.
AD  - Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Univesitas 
      Negeri Semarang, Semarang, Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20230801
PL  - Bosnia and Herzegovina
TA  - Med Glas (Zenica)
JT  - Medicinski glasnik : official publication of the Medical Association of 
      Zenica-Doboj Canton, Bosnia and Herzegovina
JID - 101250177
SB  - IM
OTO - NOTNLM
OT  - IL-10
OT  - allergic rhinitis
OT  - mesenchymal stem cells
OT  - regulatory T cells
EDAT- 2023/08/16 18:42
MHDA- 2023/08/16 18:42
CRDT- 2023/08/16 12:38
PHST- 2022/09/14 00:00 [received]
PHST- 2023/05/22 00:00 [revised]
PHST- 2023/06/05 00:00 [accepted]
PHST- 2023/08/16 18:42 [medline]
PHST- 2023/08/16 18:42 [pubmed]
PHST- 2023/08/16 12:38 [entrez]
AID - 10.17392/1541-23 [doi]
PST - aheadofprint
SO  - Med Glas (Zenica). 2023 Aug 1;20(2):175-180. doi: 10.17392/1541-23.